Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.

Abstract:

:Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whether single oral administration of CBEX (20 ml/kg) affects brain dipeptide and free amino acid concentrations in male Wistar rats. CBEX significantly and time-dependently increased carnosine and anserine levels in the plasma (at 120 min after injection, increase rates were 2976 and 4142%, respectively), hippocampus (64 and 78%), and hypothalamus (188 and 120%), but not in cerebral cortex. Significant and time-dependent increases in citrulline in the hippocampus (49%) and hypothalamus (41%) demonstrated generation of nitric oxide due to the increased carnosine and/or anserine levels in these brain regions. These findings suggest that CBEX modifies brain functions by increasing levels of these dipeptides.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Tomonaga S,Hayakawa T,Yamane H,Maemura H,Sato M,Takahata Y,Morimatsu F,Furuse M

doi

10.1080/10284150701587338

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

181-6

issue

3-4

eissn

1028-415X

issn

1476-8305

journal_volume

10

pub_type

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