Exercise and food ad libitum reduce the impact of early in life nutritional inbalances on nitrergic activity of hippocampus and striatum.

Abstract:

:Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water maze, their brains processed for NADPH-diaphorase histochemistry and quantified by densitometry. No differences were detected in water maze. At 21st day, S and L compared with M presented reduced NADPH-d in the stratum molecular of dentate gyrus (DG), stratum lacunosum of CA1 and in all CA3 layers but not in the striatum. On the 58th day, actvity remained low in S and L in CA3 and striatum and L in CA1 and DG. Voluntary exercise increased NADPH-d in DG, CA1, CA3, and striatum in S, and in the stratum lacunosum of CA1 and CA3 in L.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Viana LC,Torres JB,Farias JA,Kawhage R,Lins N,Passos A,Quintairos A,Trévia N,Guedes RC,Diniz CW

doi

10.1080/10284150701722158

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

215-28

issue

5-6

eissn

1028-415X

issn

1476-8305

journal_volume

10

pub_type

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