Feeding induced by increasing doses of neuropeptide Y: dual effect on hypothalamic serotonin release in normal rats.

Abstract:

:Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding should also stimulate serotonin, we measured its release in the LH of non-fasted rats, which received a single intracerebroventricular injection of either 1.0, 2.0, or 5.0 microg of NPY. After 1.0 microg, the cumulative 2-h intake was of 13 g and serotonin release significantly increased (54% peak). These feeding and serotonergic responses were highly similar to the ones we observed in a previous study, in which feeding followed an overnight fast. Thus, the 1.0 microg NPY dose stimulated intake while preserving the normal serotonergic activation. Contrarily, as the NPY dose was increased to either 2.0 or 5.0 microg, the cumulative 2-h intakes were of 18 g, but the serotonergic stimulation was absent. It is suggested that this dual NPY effect relies on a finely tuned control mechanism, reflecting the existence of a narrow range of NPY levels within which the serotonergic stimulation resembles those seen in physiological states.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Mori RC,Telles MM,Guimarães RB,Novo NF,Juliano Y,Nascimento CM,Ribeiro EB

doi

10.1080/10284150400012794

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

235-9

issue

4

eissn

1028-415X

issn

1476-8305

journal_volume

7

pub_type

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