Protein malnutrition during pregnancy alters maternal behavior and anxiety-like behavior in offspring.

Abstract:

OBJECTIVE:The aim of this study was to evaluate the effects of protein malnutrition during pregnancy on maternal behavior, on the early behavior in pups by ultrasonic vocalizations (USVs) emission, and on the behavior of offspring in adulthood in an elevated T-maze. METHODS:Pregnant female rats were fed a normal protein-powdered diet (22% casein; control) or a low-protein (hypoproteic) diet (6% casein; protein restriction) during the first 2 weeks of pregnancy. On the fifth postpartum day (PND5), the number of USV was rated. On PND7, maternal behavior was assessed. Male offspring in adulthood were evaluated for behavioral performance in an elevated T-maze. RESULTS:Our results demonstrated that a hypoproteic diet during early pregnancy increased the maternal behavior, increased the number of USV by pups, and reduced the inhibitory avoidance responses in an elevated T-maze during adulthood. In addition, there was a reduction in weight gain of rats during pregnancy and of offspring during lactation. CONCLUSION:In conclusion, the data found in our study suggest that the increase in USV emitted by pups due to hypoproteic diet during pregnancy accentuated maternal behavior. In addition, an increase in maternal care promoted the reduction in anxiety-like behavior in adult male offspring.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Batista TH,Veronesi VB,Ribeiro ACAF,Giusti-Paiva A,Vilela FC

doi

10.1080/1028415X.2016.1177320

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

437-442

issue

8

eissn

1028-415X

issn

1476-8305

journal_volume

20

pub_type

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