Abstract:
OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passive avoidance learning (PAL) and memory task in comparison with donepezil, a reference drug. We also evaluated the levels of superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation in hippocampus as possible mechanisms. METHODS:Memory impairment was induced by 15% w/v ethanol (2 g/kg, i.g.) administration for 30 days. RA (8, 16, and 32 mg/kg, i.g.) or donepezil (2 mg/kg, i.g.) was administered 30 minutes before ethanol. The acquisition trial was done 1 hour after the last administration of RA and donepezil. At the end, animals were weighed and hippocami were isolated for analyzing of oxidant/antioxidant markers. RESULTS:Ethanol caused cognition deficits in the PAL and memory task. While RA 16 and 32 mg/kg improved cognition in control rats, it prevented learning and memory deficits of alcoholic groups. RA 8 mg/kg did not influence cognitive function in both control and alcoholic rats. RA 32 mg/kg had comparable effects with donepezil in prevention of acquisition and retention memory impairment. The higher doses of RA not only prevented increased lipid peroxidation and nitrite content but also decreased SOD, CAT, GSH, and FRAP levels in alcoholic groups and exerted antioxidant effects in non-alcoholic rats. DISCUSSION:We showed that RA administration dose-dependently prevented cognitive impairment induced by chronic ethanol in PAL and memory and disturbed oxidant/antioxidant status as a possible mechanism. The antioxidant, anticholinesterase, and neuroprotective properties of RA may be involved in the observed effects. Therefore, RA represents a potential therapeutic option against chronic ethanol-induced amnesia which deserves consideration and further examination.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Hasanein P,Seifi R,Hajinezhad MR,Emamjomeh Adoi
10.1080/1028415X.2016.1203125subject
Has Abstractpub_date
2017-11-01 00:00:00pages
547-554issue
9eissn
1028-415Xissn
1476-8305journal_volume
20pub_type
杂志文章abstract::The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,评审
doi:10.1179/147683009X423454
更新日期:2009-10-01 00:00:00
abstract::Objective: Amylin acts on the lateral dorsal tegmental nucleus (LDT), resulting in anorexic and weight-loss effects and activates thermogenesis in the interscapular brown adipose tissue (IBAT). In addition, it induces neuronal nitric oxide synthase (nNOS) and choline acetyltransferase (ChAT)-mediated feeding. However,...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1752998
更新日期:2020-04-25 00:00:00
abstract:OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000032
更新日期:2015-01-01 00:00:00
abstract::We examined whether diabetes mellitus (DM) affects the acute ethanol (EtOH)-induced increase in serotonin (5-HT) release from the rat hippocampus, and compared the findings with those obtained from non-DM rats. Hippocampal 5-HT was measured by using in vivo microdialysis. Rats were rendered diabetic by an injection of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830511Y.0000000006
更新日期:2011-05-01 00:00:00
abstract::This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in n...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683008X301522
更新日期:2008-06-01 00:00:00
abstract::Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for AS...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1557385
更新日期:2020-10-01 00:00:00
abstract::Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747313
更新日期:2000-01-01 00:00:00
abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1585506
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here, we analyze whether the early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters i...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000012
更新日期:2016-11-01 00:00:00
abstract::Objectives: Unfavorable lactation influences brain excitability and behavioral reactions in adults. Administration early in life of the cholinergic agonist, pilocarpine, even at non-convulsive doses, alters the brain excitability-related phenomenon known as cortical spreading depression (CSD), and produce anxiogenic-l...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819103
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000006
更新日期:2016-05-01 00:00:00
abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747212
更新日期:1998-01-01 00:00:00
abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X423328
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND RATIONALE:Certain nutritional supplements are being marketed for the management of Alzheimer's disease (AD), but the evidence for their effectiveness is not established. The objective of this review was to evaluate the evidence from randomized clinical trial (RCTs) examining the effect of Souvenaid in pa...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,meta分析,评审
doi:10.1080/1028415X.2015.1110899
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1476830515Y.0000000018
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819104
更新日期:2020-09-21 00:00:00
abstract::Introduction: Phytoestrogens are non-steroidal estrogen analogues and are found primarily in soy products. They have received increasing attention as dietary supplements for estrogen deficiency and as modulators of endogenous estrogen functions, including cognition and emotion. In addition to modifying the levels of c...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1698826
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000151
更新日期:2016-01-01 00:00:00
abstract::Introduction: Oxidative stress is known to contribute to the pathogenesis of neurodegenerative disorders. An ethanolic turmeric (Curcuma longa L.) extract containing curcumin has been reported to produce antioxidant effects. Objective: The present study aims to investigate the possible neuroprotective effects of the e...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1447267
更新日期:2019-11-01 00:00:00
abstract::Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1841482
更新日期:2020-11-08 00:00:00
abstract:OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000033
更新日期:2016-06-01 00:00:00
abstract::Primary brain injury in stroke is followed by an excitotoxic cascade, oxidative stress and further neural damage. Glutathione is critical and depleted in oxidative stress. Since cysteine is limiting in glutathione synthesis, this study investigated the effect of dietary sulfur amino acid (SAA) deficiency on neural dam...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415021000055952
更新日期:2002-12-01 00:00:00
abstract::Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章
doi:10.1080/1028415x.2001.11747356
更新日期:2001-01-01 00:00:00
abstract::Background: The aetiology of Attention Deficit Hyperactivity Disorder (ADHD) continues to be debated, although several contributing factors have been acknowledged. Objective: Assess the association between weight, birth attributes, exercise and sleep habits, dietary intake and adherence to a Mediterranean diet, and im...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1660486
更新日期:2019-09-03 00:00:00
abstract:RATIONALE:Recent research suggests that chewing gum may increase alertness and lead to changes in cognitive performance. The present study examined effects of chewing gum on these functions within the context of a single study. OBJECTIVES:This study had four main aims. The first was to examine whether chewing gum impr...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X423247
更新日期:2009-04-01 00:00:00
abstract::Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747329
更新日期:2000-01-01 00:00:00
abstract::Objectives: Glucocorticoid receptor (GR) expressed in hippocampus is critical for the homeostasis of stress responses and susceptible to epigenetic modulation caused by maternal factors. Here we show that maternal methyl nutrition causes sex-biased changes in hippocampal expression of GR exon 1 mRNA variants, associat...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1807711
更新日期:2020-08-25 00:00:00
abstract::Objectives: Apigenin is the most common bioflavonoid known to be biologically active after systemic administration and show multiple pharmacological effects. The present study was designed to explore the role of apigenin in pentylenetetrazole (PTZ) kindling associated cognitive and behavioural impairments in the mouse...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1478653
更新日期:2020-02-01 00:00:00
abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683008X301388
更新日期:2008-02-01 00:00:00
abstract::Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic op...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,评审
doi:10.1080/1028415X.2016.1236174
更新日期:2018-02-01 00:00:00