Abstract:
OBJECTIVES:Genistein is a plant-derived estrogenic isoflavone commonly found in dietary and therapeutic supplements, due to its potential health benefits. Growth hormone-releasing hormone (GHRH) and somatostatin (SS) are neurosecretory peptides synthesized in neurons of the hypothalamus and regulate the growth hormone secretion. Early reports indicate that estrogens have highly involved in the regulation of GHRH and SS secretions. Since little is known about the potential effects of genistein on GHRH and SS neurons, we exposed rats to genistein. METHODS:Genistein were administered to adult rats in dose of 30 mg/kg, for 3 weeks. The estradiol-dipropionate treatment was used as the adequate controls to genistein. Using applied stereology on histological sections of hypothalamus, we obtained the quantitative information on arcuate (Arc) and periventricular (Pe) nucleus volume and volume density of GHRH neurons and SS neurons. Image analyses were used to obtain GHRH and SS contents in the median eminence (ME). RESULTS:Administration of estradiol-dipropionate caused the increase of Arc and Pe nucleus volume, SS neuron volume density, GHRH and SS staining intensity in the ME, when compared with control. Genistein treatment increased: Arc nucleus volume and the volume density of GHRH neurons (by 26%) and SS neurons (1.5 fold), accompanied by higher GHRH and SS staining intensity in the ME, when compared to the orhidectomized group. DISCUSSION:These results suggest that genistein has a significant effect on hypothalamic region, involved in the regulation of somatotropic system function, and could contribute to the understanding of genistein as substance that alter the hormonal balance.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Trifunović S,Manojlović-Stojanoski M,Ristić N,Nestorović N,Medigović I,Živanović J,Milošević Vdoi
10.1179/1476830514Y.0000000143subject
Has Abstractpub_date
2016-12-01 00:00:00pages
467-474issue
10eissn
1028-415Xissn
1476-8305journal_volume
19pub_type
杂志文章abstract::The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683010X12611460764246
更新日期:2010-08-01 00:00:00
abstract::Objective: We evaluate whether the consumption of fructose for 8 weeks affects enzymes and transcription factors of the lipogenic and inflammatory pathways in the hypothalamus of Wistar rats. Methods: At 30 days, the animals were divided into groups: Control (C) and Fructose (F) and maintained with free access to feed...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1427659
更新日期:2019-09-01 00:00:00
abstract::Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1179/147683010X12611460764084
更新日期:2010-06-01 00:00:00
abstract::Objectives: This study was designed to investigate the vitamin A (VA) and vitamin D (VD) levels in children with autism spectrum disorders (ASD) and to determine whether co-deficiency of VA and VD exacerbates clinical symptoms in autistic children. Methods: The Autism Behavior Checklist, Childhood Autism Rating Scale ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2017.1423268
更新日期:2019-09-01 00:00:00
abstract::In this article, the second of a series on the analysis of time to event data, we address the case in which multiple predictors (covariates) that may influence the time to an event are taken into account. The hazard function is introduced, and is given in a form useful for assessing the impact of multiple covariates o...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415031000079694
更新日期:2003-04-01 00:00:00
abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1585506
更新日期:2021-01-01 00:00:00
abstract::This study examined effects of a single protein-free (PROT-free), high carbohydrate meal (0% protein, 82% carbohydrate) or control meal (20% protein, 62% carbohydrate) on coping behavior and neurotransmitter levels of male Fischer 344 rats. Meals varying in protein/carbohydrate ratio differentially affect transport of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150400017330
更新日期:2004-10-01 00:00:00
abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X423328
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000033
更新日期:2016-06-01 00:00:00
abstract::Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water ma...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150701722158
更新日期:2007-10-01 00:00:00
abstract::Sensory awareness contributes to the enjoyment of eating and drinking. This study tested the hypothesis that changes in the intensity of oral sensations could be used to regulate the volume of intake. Forty women (< 36 years) volunteered. The participants consumed distilled water, salt water and two concentrations of ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150500449029
更新日期:2005-08-01 00:00:00
abstract::Background: Adherence to a Mediterranean diet is associated with higher cognitive function and reduced risk of dementia in Mediterranean populations. However, few studies have investigated the association between Mediterranean diet adherence and cognition in populations outside of the Mediterranean basin. Furthermore,...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1655201
更新日期:2019-08-21 00:00:00
abstract::Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415042000198807
更新日期:2004-02-01 00:00:00
abstract::Background: Multiple sclerosis (MS) is associated with changes in quality of life, disability, fatigue and anthropometric measurements. The important relationship of dietary patterns with such clinical manifestations was not completely investigated. Aims: The goal of this study was to define the dietary patterns and t...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1580831
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages. The aim of the presen...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2015.1126444
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Recent research suggests that chewing gum may increase alertness and lead to changes in cognitive performance. The present study examined effects of chewing gum on these functions within the context of a single study. OBJECTIVES:This study had four main aims. The first was to examine whether chewing gum impr...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X423247
更新日期:2009-04-01 00:00:00
abstract::Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747313
更新日期:2000-01-01 00:00:00
abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1863740
更新日期:2020-12-29 00:00:00
abstract::Theanine, γ-glutamylethylamide, is one of the major amino acid components in green tea. On the basis of the preventive effect of theanine intake after weaning on stress-induced impairment of recognition memory, the advantageous effect of theanine intake on recognition memory was examined in young rats, which were fed ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830513Y.0000000094
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1476830515Y.0000000018
更新日期:2016-05-01 00:00:00
abstract::Objective: Although dietary patterns have been evaluated in relation to psychological disorders, their associations with psychosomatic complaints are unclear. We investigated relations of dietary patterns with psychosomatic complaints profiles.Methods: In this cross-sectional study, a total of 3363 adults were include...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1485611
更新日期:2020-03-01 00:00:00
abstract::Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox home...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1501532
更新日期:2020-04-01 00:00:00
abstract::Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1584692
更新日期:2021-01-01 00:00:00
abstract::The effects of perinatal undernutrition on the number of neurons and apoptotic cells of the locus coeruleus (LC) of female and male rats at postpartum days 7, 12, 20, 30 and 60 were studied. Undernutrition reduces the number of neurons in both sexes without affecting cell death, as indicated by the ratio of apoptotic ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150600937873
更新日期:2006-10-01 00:00:00
abstract::We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/110284150600955164
更新日期:2006-06-01 00:00:00
abstract::Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747329
更新日期:2000-01-01 00:00:00
abstract::Background: The aetiology of Attention Deficit Hyperactivity Disorder (ADHD) continues to be debated, although several contributing factors have been acknowledged. Objective: Assess the association between weight, birth attributes, exercise and sleep habits, dietary intake and adherence to a Mediterranean diet, and im...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1660486
更新日期:2019-09-03 00:00:00
abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747224
更新日期:1998-01-01 00:00:00
abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1809875
更新日期:2020-10-09 00:00:00
abstract::Moderately low-protein diets lead to a rapid increase in food intake and body fat. The increase in feeding is associated with a decrease in the concentration of serum urea nitrogen, suggesting that the low-protein-induced increase in food intake may be related to the decreased metabolism of nitrogen from amino acids. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150310001640365
更新日期:2003-12-01 00:00:00