Abstract：
:Objective: We evaluate whether the consumption of fructose for 8 weeks affects enzymes and transcription factors of the lipogenic and inflammatory pathways in the hypothalamus of Wistar rats. Methods: At 30 days, the animals were divided into groups: Control (C) and Fructose (F) and maintained with free access to feed and filtered water (C) or aqueous solution of purified fructose at 20% (F). RT-PCR and Western blotting were performed for the target genes and proteins. Results: In F group, results showed a lower feed intake, an increase in glycemia (146.20 ± 6.09 vs. 102.32 ± 4.58; n: 9) and triacylglycerol (F: 191.65 ± 13.51 vs. C: 131.69 ± 6.49; n: 9) and there was no difference in water and energy consumption. We identified a higher content of acetyl-CoA carboxylase (ACC) (F: 133.93 ± 5.58 vs. C: 100 ± 0.0; n: 9-10) and NFκB (F: 125.5 ± 8.85 vs. C: 100 ± 0; n: 14) in group F, whereas fatty acid synthase (FAS) was lower (F: 85.90 ± 4.81 vs. C: 100 ± 0.0; n: 4-6). SREBP-1c gene expression was higher in F vs. C group (F: 4.08 ± 0.44 vs. C: 1.13 ± 0.15; n: 5-6), although we did not found difference between groups in the gene expression for ACC, SREBP-2, and NFκB. Discussion: Dietary fructose can change important lipogenic and inflammatory factors in the hypothalamus of rats and it leads to regulation of transcription factors before changes in body mass are evident.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Batista LO,Ramos VW,Rosas Fernández MA,Concha Vilca CM,Albuquerque KTdoi
10.1080/1028415X.2018.1427659subject
Has Abstractpub_date
2019-09-01 00:00:00pages
648-654issue
9eissn
1028-415Xissn
1476-8305journal_volume
22pub_type
杂志文章abstract：OBJECTIVE:The aim of this study was to evaluate the effects of protein malnutrition during pregnancy on maternal behavior, on the early behavior in pups by ultrasonic vocalizations (USVs) emission, and on the behavior of offspring in adulthood in an elevated T-maze. METHODS:Pregnant female rats were fed a normal prote...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1177320
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1819104
更新日期：2020-09-21 00:00:00
abstract：:Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150601168346
更新日期：2007-02-01 00:00:00
abstract：:Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2000.11747329
更新日期：2000-01-01 00:00:00
abstract：:Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding shou...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150400012794
更新日期：2004-08-01 00:00:00
abstract：:The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747269
更新日期：1999-01-01 00:00:00
abstract：:The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683010X12611460764246
更新日期：2010-08-01 00:00:00
abstract：:Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects...
journal_title：Nutritional neuroscience
pub_type： 临床试验,杂志文章
doi：10.1080/1028415x.2001.11747356
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1443996
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000006
更新日期：2016-05-01 00:00:00
abstract：:Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150500506042
更新日期：2006-02-01 00:00:00
abstract：:This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150412331281031
更新日期：2004-06-01 00:00:00
abstract：:Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1468535
更新日期：2020-01-01 00:00:00
abstract：:The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X423328
更新日期：2009-08-01 00:00:00
abstract：:The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,评审
doi：10.1179/147683009X423454
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVES:Sodium metabisulfite as a food preservative can affect the central nervous system. Curcumin, the main ingredient of turmeric has neuroprotective activity. This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods. METHODS:Thirt...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830514Y.0000000123
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830512Y.0000000020
更新日期：2012-11-01 00:00:00
abstract：:The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2000.11747309
更新日期：2000-01-01 00:00:00
abstract：:Background: Adherence to a Mediterranean diet is associated with higher cognitive function and reduced risk of dementia in Mediterranean populations. However, few studies have investigated the association between Mediterranean diet adherence and cognition in populations outside of the Mediterranean basin. Furthermore,...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1655201
更新日期：2019-08-21 00:00:00
abstract：:Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2000.11747313
更新日期：2000-01-01 00:00:00
abstract：:Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415042000198807
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:This study was designed to review the effect of chronic aluminium exposure on interleukin-6 (IL-6) secretion in the posterior brain and test the putative modulating effect of fenugreek seeds. METHODS:Female Wistar rats were divided into four groups: control; AlCl3 during 5 months (500 mg/kg body weight, intr...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830512Y.0000000048
更新日期：2013-09-01 00:00:00
abstract：:Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1584692
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000032
更新日期：2015-01-01 00:00:00
abstract：:Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1863740
更新日期：2020-12-29 00:00:00
abstract：:Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the off...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747258
更新日期：1999-01-01 00:00:00
abstract：:Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for AS...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1557385
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here, we analyze whether the early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters i...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000012
更新日期：2016-11-01 00:00:00
abstract：:Objectives: Apigenin is the most common bioflavonoid known to be biologically active after systemic administration and show multiple pharmacological effects. The present study was designed to explore the role of apigenin in pentylenetetrazole (PTZ) kindling associated cognitive and behavioural impairments in the mouse...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1478653
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages. The aim of the presen...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2015.1126444
更新日期：2017-07-01 00:00:00
