Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders.

Abstract:

:Objectives: This study was designed to investigate the vitamin A (VA) and vitamin D (VD) levels in children with autism spectrum disorders (ASD) and to determine whether co-deficiency of VA and VD exacerbates clinical symptoms in autistic children. Methods: The Autism Behavior Checklist, Childhood Autism Rating Scale (CARS), and Social Responsiveness Scale (SRS) were used to assess the symptoms of 332 children diagnosed as ASD. And the Gesell Developmental Scale (GDS) was used to evaluate neurodevelopment in children with ASD. Anthropometric measurement and questionnaire results were compared for all autistic children and 197 age- and gender-matched control children. Serum retinol levels were detected with high-performance liquid chromatography, and serum levels of 25-OH vitamin D were measured with an immunoassay method in the two groups. Results: The ZHA, ZWA, and ZBMIA of the children with ASD were significantly lower than those of the control children. Furthermore, higher proportions of children with picky eating, resistance to new foods, and eating problems were observed in the ASD group when compared with the control group. Serum retinol and 25-OH vitamin D levels in autistic children were significantly lower than those in the control children. Additionally, VA and VD co-deficiency impacts more on the symptoms and development in autistic children. Conclusions: We found that children with autism have more VA and VD deficiencies than control children, and VA and VD co-deficiency may exacerbate the symptoms of children with ASD.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Guo M,Zhu J,Yang T,Lai X,Lei Y,Chen J,Li T

doi

10.1080/1028415X.2017.1423268

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

637-647

issue

9

eissn

1028-415X

issn

1476-8305

journal_volume

22

pub_type

杂志文章
  • Association of blood antioxidants status with visual and auditory sustained attention.

    abstract:OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830515Y.0000000032

    authors: Shiraseb F,Siassi F,Sotoudeh G,Qorbani M,Rostami R,Sadeghi-Firoozabadi V,Narmaki E

    更新日期:2015-01-01 00:00:00

  • A Saturated-Fat Diet during Development Alters Dendritic Growth in Mouse Brain.

    abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747212

    authors: Wainwright PE,Bulman-Fleming MB,Lévesque S,Mutsaers L,McCutcheon D

    更新日期:1998-01-01 00:00:00

  • Volume of the Sexually Dimorphic Nucleus of the Preoptic Area in Rats Exposed to a Maternal High Fat Diet.

    abstract::Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the off...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747258

    authors: Walker BE

    更新日期:1999-01-01 00:00:00

  • The neuroprotective effects of an ethanolic turmeric (Curcuma longa L.) extract against trimethyltin-induced oxidative stress in rats.

    abstract::Introduction: Oxidative stress is known to contribute to the pathogenesis of neurodegenerative disorders. An ethanolic turmeric (Curcuma longa L.) extract containing curcumin has been reported to produce antioxidant effects. Objective: The present study aims to investigate the possible neuroprotective effects of the e...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1447267

    authors: Yuliani S,Mustofa,Partadiredja G

    更新日期:2019-11-01 00:00:00

  • Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.

    abstract::Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150701587338

    authors: Tomonaga S,Hayakawa T,Yamane H,Maemura H,Sato M,Takahata Y,Morimatsu F,Furuse M

    更新日期:2007-06-01 00:00:00

  • Malnutrition and REM-sleep deprivation modulate in rats the impairment of spreading depression by a single sub-convulsing dose of pilocarpine.

    abstract::This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150412331281031

    authors: De Vasconcelos CA,De Oliveira JA,De Oliveira Costat LA,Guedes RC

    更新日期:2004-06-01 00:00:00

  • Effects of chewing gum on mood, learning, memory and performance of an intelligence test.

    abstract:RATIONALE:Recent research suggests that chewing gum may increase alertness and lead to changes in cognitive performance. The present study examined effects of chewing gum on these functions within the context of a single study. OBJECTIVES:This study had four main aims. The first was to examine whether chewing gum impr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X423247

    authors: Smith A

    更新日期:2009-04-01 00:00:00

  • The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.

    abstract::The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X388850

    authors: Márquez-Valadez B,Lugo-Huitrón R,Valdivia-Cerda V,Miranda-Ramírez LR,Pérez-De La Cruz V,González-Cuahutencos O,Rivero-Cruz I,Mata R,Santamaría A,Pedraza-Chaverrí J

    更新日期:2009-02-01 00:00:00

  • No association between cognitive achievements, academic performance and serum cholesterol concentrations among school-aged children.

    abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X423328

    authors: Perry LA,Stigger CB,Ainsworth BE,Zhang J

    更新日期:2009-08-01 00:00:00

  • Autism and Schizophrenia: Intestinal Disorders.

    abstract::We examined Dohan's hypothesis that schizophrenia is associated with the absorption of "exorphins" contained in gluten and casein. In addition, because of the work of Reichelt et al. (Reichelt, K.L., Saelid, G., Lindback, J. and Orbeck, H. (1986) Biological Psychiatry 21:1279-1290) and Rodriguez et al. (Rodriguez, Tra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747303

    authors: Cade R,Privette M,Fregly M,Rowland N,Sun Z,Zele V,Wagemaker H,Edelstein C

    更新日期:2000-01-01 00:00:00

  • Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.

    abstract::Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830510Y.0000000001

    authors: Pifferi F,Tremblay S,Croteau E,Fortier M,Tremblay-Mercier J,Lecomte R,Cunnane SC

    更新日期:2011-03-01 00:00:00

  • Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats.

    abstract:OBJECTIVES:Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model. METHODS:The rats were divided into control group received just...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000137

    authors: Mohammadpour T,Hosseini M,Naderi A,Karami R,Sadeghnia HR,Soukhtanloo M,Vafaee F

    更新日期:2015-10-01 00:00:00

  • Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study.

    abstract::We examined whether diabetes mellitus (DM) affects the acute ethanol (EtOH)-induced increase in serotonin (5-HT) release from the rat hippocampus, and compared the findings with those obtained from non-DM rats. Hippocampal 5-HT was measured by using in vivo microdialysis. Rats were rendered diabetic by an injection of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830511Y.0000000006

    authors: Nagata T,Nishiyama A,Yamato T,Obata T,Aomine M

    更新日期:2011-05-01 00:00:00

  • Low dietary protein is associated with an increase in food intake and a decrease in the in vitro release of radiolabeled glutamate and GABA from the lateral hypothalamus.

    abstract::Moderately low-protein diets lead to a rapid increase in food intake and body fat. The increase in feeding is associated with a decrease in the concentration of serum urea nitrogen, suggesting that the low-protein-induced increase in food intake may be related to the decreased metabolism of nitrogen from amino acids. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150310001640365

    authors: White BD,Du F,Higginbotham DA

    更新日期:2003-12-01 00:00:00

  • Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States.

    abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1794422

    authors: Bigman G

    更新日期:2020-07-20 00:00:00

  • Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.

    abstract::The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683010X12611460764246

    authors: Miñana-Solis Mdel C,Angeles-Castellanos M,Buijs RM,Escobar C

    更新日期:2010-08-01 00:00:00

  • Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments.

    abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X301388

    authors: Marton E,Feletti A,Mazzucco GM,Longatti P

    更新日期:2008-02-01 00:00:00

  • Lactobacillus helveticus-fermented milk improves learning and memory in mice.

    abstract:OBJECTIVES:To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. METHODS:We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learni...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000122

    authors: Ohsawa K,Uchida N,Ohki K,Nakamura Y,Yokogoshi H

    更新日期:2015-07-01 00:00:00

  • Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.

    abstract:OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1203125

    authors: Hasanein P,Seifi R,Hajinezhad MR,Emamjomeh A

    更新日期:2017-11-01 00:00:00

  • Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers.

    abstract::The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,评审

    doi:10.1179/147683009X423454

    authors: Rosales FJ,Reznick JS,Zeisel SH

    更新日期:2009-10-01 00:00:00

  • Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

    abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747241

    authors: Vadnal R

    更新日期:1998-01-01 00:00:00

  • Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review.

    abstract::Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for AS...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1557385

    authors: Infante M,Sears B,Rizzo AM,Mariani Cerati D,Caprio M,Ricordi C,Fabbri A

    更新日期:2020-10-01 00:00:00

  • Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers--a randomized crossover study.

    abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000018

    authors: Zimmermann-Viehoff F,Thayer J,Koenig J,Herrmann C,Weber CS,Deter HC

    更新日期:2016-05-01 00:00:00

  • Association between poor nutritional status and severe depression in Korean cerebral infarction patients.

    abstract:OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830511Y.0000000023

    authors: Lim HJ,Choue R

    更新日期:2012-01-01 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Evaluation of the antidepressant- and anxiolytic-like effects of a hydrophilic extract from the green seaweed Ulva sp. in rats.

    abstract:OBJECTIVES:The green seaweed Ulva sp. contains a large amount of ulvans, a family of sulphated polysaccharides. The present study was designed to investigate in rats the antidepressant- and anxiolytic-like effects of a hydrophilic extract of Ulva sp. (MSP) containing about 45% of ulvans. METHODS:After a 14-day adminis...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1276704

    authors: Violle N,Rozan P,Demais H,Nyvall Collen P,Bisson JF

    更新日期:2018-05-01 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

    abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000151

    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

    更新日期:2016-01-01 00:00:00

  • Ghrelin as a prominent endocrine factor in stress-induced obesity.

    abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1863740

    authors: van Loenen MR,Geenen B,Arnoldussen IAC,Kiliaan AJ

    更新日期:2020-12-29 00:00:00

  • Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene expression in chicks.

    abstract:OBJECTIVE:The objective of this study was to determine the influence of dietary macronutrient composition on central NPY's orexigenic effect in chicks. METHODS:Day-of-hatch chicks were fed one of three diets (3000 kcal ME/kg) ad libitum from hatch: high carbohydrate (HC), high fat (HF; 30% ME derived from soybean oil)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2017.1296606

    authors: McConn BR,Cline MA,Gilbert ER

    更新日期:2018-07-01 00:00:00

  • Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.

    abstract::Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415042000198807

    authors: D'Anci KE,Kanarek RB

    更新日期:2004-02-01 00:00:00