Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

Abstract:

BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. METHODS:Male Wistar rats were given 10 mg/kg b.w. of trivalent inorganic arsenic (in the form of NaAsO2), 5 day/week for 6 weeks by gavage, combined with vitamin C solution (1 g/l) or green tea infusion (2.5 g in 500 ml boiled water) as antioxidants given in the drinking fluid. RESULTS:Body weight gain was reduced by arsenic from the second week and the antioxidants had no effect on that. Cortical evoked potentials had increased latency, tail nerve conduction velocity was reduced, and this latter effect was counteracted by the antioxidants. The effect of green tea was stronger than that of vitamin C, and green tea also diminished lipid peroxidation induced by As. There was fair correlation between brain As levels, electrophysiological changes, and lipid peroxidation, suggesting a causal relationship. DISCUSSION:Natural antioxidants might be useful in the protection of the central nervous system against the toxicity of oral As.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

doi

10.1179/1476830514Y.0000000151

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

102-9

issue

3

eissn

1028-415X

issn

1476-8305

journal_volume

19

pub_type

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