Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.

Abstract:

:The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a balanced diet until 90 days (MGL-R and MPW-R, respectively). After a glucose tolerance test (GTT), brains were processed for Fos immunoreactivity (Fos-IR). Both malnourished groups displayed hyperglycemia after GTT. MGL exhibited an increased number of Fos-IR neurons in the ventromedial hypothalamic nucleus (VMH), while MPW showed increased Fos-IR in the arcuate nucleus (ARC) and VMH and a decrease in the paraventricular nucleus (PVN), as compared with their controls. Nutritional rehabilitation normalized values of glucose after GTT in both groups, while low number of Fos-IR neurons remained in the ARC, PVN and VMH of MPW-R rats, indicating a deleterious, long-lasting effect after post-weaning malnutrition.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Miñana-Solis Mdel C,Angeles-Castellanos M,Buijs RM,Escobar C

doi

10.1179/147683010X12611460764246

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

152-60

issue

4

eissn

1028-415X

issn

1476-8305

journal_volume

13

pub_type

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