The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis.


OBJECTIVES:To explore the association between dietary factors including fat, fruit and vegetable intake, dairy and meat consumption, and health-related quality of life (HRQOL), disability and relapse rate in a large international sample of people with multiple sclerosis (MS). METHODS:Participants with MS were recruited to the study via Web 2.0 platforms and completed a comprehensive survey measuring demographic and clinical characteristics, HRQOL, disability, relapse rate, and the Diet Habits Questionnaire (DHQ). RESULTS:Of 2469 participants with confirmed MS, 2087 (84.5%) provided complete data on their dietary habits (DHQ total score). Multivariate regression models demonstrated that every 10-point increase on the DHQ total score was associated with nearly a six-point and five-point increase in physical and mental HRQOL, respectively, and 30.0% reduced likelihood of a higher level of disability. After controlling for age and gender, and the other dietary covariates, 'healthy' consumption of fruit and vegetables and dietary fat predicted better quality of life and less likelihood of higher disability when compared to respondents with a 'poor' diet. For those with relapsing-remitting MS, the DHQ total significantly predicted a lower relapse rate and reduced odds of increasing disease activity, but the model fit was poor and the predicted change only marginal. DISCUSSION:This study supports significant associations of healthy dietary habits with better physical and mental HRQOL and a lower level of disability. Further research is urgently required to explore these associations including randomized controlled trials of dietary modification for people with MS.


Nutr Neurosci


Nutritional neuroscience


Hadgkiss EJ,Jelinek GA,Weiland TJ,Pereira NG,Marck CH,van der Meer DM




Has Abstract


2015-04-01 00:00:00












  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Sex-biased transgenerational transmission of betaine-induced epigenetic modifications in glucocorticoid receptor gene and its down-stream BDNF/ERK pathway in rat hippocampus.

    abstract::Objectives: Glucocorticoid receptor (GR) expressed in hippocampus is critical for the homeostasis of stress responses and susceptible to epigenetic modulation caused by maternal factors. Here we show that maternal methyl nutrition causes sex-biased changes in hippocampal expression of GR exon 1 mRNA variants, associat...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Yang Y,Yang S,Jia Y,Yin C,Zhao R

    更新日期:2020-08-25 00:00:00

  • Analyzing data in which the outcome is time to an event part II: The presence of multiple covariates.

    abstract::In this article, the second of a series on the analysis of time to event data, we address the case in which multiple predictors (covariates) that may influence the time to an event are taken into account. The hazard function is introduced, and is given in a form useful for assessing the impact of multiple covariates o...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mera R,Thompson HW,Prasad C

    更新日期:2003-04-01 00:00:00

  • Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene expression in chicks.

    abstract:OBJECTIVE:The objective of this study was to determine the influence of dietary macronutrient composition on central NPY's orexigenic effect in chicks. METHODS:Day-of-hatch chicks were fed one of three diets (3000 kcal ME/kg) ad libitum from hatch: high carbohydrate (HC), high fat (HF; 30% ME derived from soybean oil)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: McConn BR,Cline MA,Gilbert ER

    更新日期:2018-07-01 00:00:00

  • Relationships between Pregnancy and Vitamin B-6 Nutriture on Brain 3-Hydroxykynurenine Concentrations in Mice.

    abstract::The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: van de Kamp JL,Smolen A

    更新日期:2000-01-01 00:00:00

  • Recognition of oral sensory satisfaction and regulation of the volume of intake in humans.

    abstract::Sensory awareness contributes to the enjoyment of eating and drinking. This study tested the hypothesis that changes in the intensity of oral sensations could be used to regulate the volume of intake. Forty women (< 36 years) volunteered. The participants consumed distilled water, salt water and two concentrations of ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Poothullil JM

    更新日期:2005-08-01 00:00:00

  • The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis.

    abstract:OBJECTIVES:It has been shown that calcitriol and all-trans retinoic acid (ATRA) have modulatory effects on the immune system. The present study investigates the synergistic effects of combination treatment of calcitriol and ATRA in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Parastouei K,Mirshafiey A,Eshraghian MR,Shiri-Shahsavar MR,Solaymani-Mohammadi F,Chahardoli R,Alvandi E,Saboor-Yaraghi AA

    更新日期:2018-04-01 00:00:00

  • Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population.

    abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Zhou Y,Chen J,Gong X,Lu Z,Hua H,Zhu X,Shi P,Li X,Zhou S,Wang Y,Qian T

    更新日期:2021-01-23 00:00:00

  • Lactation in large litters influences anxiety, memory, and spreading depression in adult male rats that were chronically subjected to a non-convulsive pilocarpine dose.

    abstract::Objectives: Unfavorable lactation influences brain excitability and behavioral reactions in adults. Administration early in life of the cholinergic agonist, pilocarpine, even at non-convulsive doses, alters the brain excitability-related phenomenon known as cortical spreading depression (CSD), and produce anxiogenic-l...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Benevides RDL,de-Lima SMV,Chagas CL,de Lima CF,Abadie-Guedes R,Guedes RCA

    更新日期:2020-09-11 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress.

    abstract::To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Kurauchi I,Shigemi K,Kabuki Y,Hamasu K,Yamane H,Aoki M,Kawada Y,Morishita K,Denbow DM,Furuse M

    更新日期:2010-02-01 00:00:00

  • Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats.

    abstract::Depression is a major public health problem affecting about 12% of the world population. Drugs exist but they have many side effects. In the last few years, natural substances (e.g. flavonoids) have been tested to cure such disorders. Cocoa polyphenolic extract is a complex compound prepared from non-roasted cocoa bea...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Messaoudi M,Bisson JF,Nejdi A,Rozan P,Javelot H

    更新日期:2008-12-01 00:00:00

  • Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense.

    abstract::Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Dos Santos E,Radai JAS,do Nascimento KF,Formagio ASN,de Matos Balsalobre N,Ziff EB,Castelon Konkiewitz E,Kassuya CAL

    更新日期:2020-09-11 00:00:00

  • Association between des-acyl ghrelin at fasting and predictive index of muscle derangement, metabolic markers and eating disorders: a cross-sectional study in overweight and obese adults.

    abstract::Background: This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders.Materials & Methods: A total of 88 subjects (64 women and 24 men,...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Perna S,Spadaccini D,Gasparri C,Peroni G,Infantino V,Iannello G,Riva A,Petrangolini G,Alalwan TA,Al-Thawadi S,Rondanelli M

    更新日期:2020-04-15 00:00:00

  • Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.

    abstract:OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Hasanein P,Seifi R,Hajinezhad MR,Emamjomeh A

    更新日期:2017-11-01 00:00:00

  • The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.

    abstract::The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Márquez-Valadez B,Lugo-Huitrón R,Valdivia-Cerda V,Miranda-Ramírez LR,Pérez-De La Cruz V,González-Cuahutencos O,Rivero-Cruz I,Mata R,Santamaría A,Pedraza-Chaverrí J

    更新日期:2009-02-01 00:00:00

  • Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus.

    abstract::Objectives: Apigenin is the most common bioflavonoid known to be biologically active after systemic administration and show multiple pharmacological effects. The present study was designed to explore the role of apigenin in pentylenetetrazole (PTZ) kindling associated cognitive and behavioural impairments in the mouse...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Sharma P,Sharma S,Singh D

    更新日期:2020-02-01 00:00:00

  • Moderate Alcohol Intake: Behavioral and Neurochemical Correlates in Rats.

    abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Battaini F,Pascale A,Ancona DM,Cagiano R,Cuomo V,Govoni S

    更新日期:1998-01-01 00:00:00

  • The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers.

    abstract:OBJECTIVE:The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS:The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical work...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,随机对照试验


    authors: Mohammadi AA,Jazayeri S,Khosravi-Darani K,Solati Z,Mohammadpour N,Asemi Z,Adab Z,Djalali M,Tehrani-Doost M,Hosseini M,Eghtesadi S

    更新日期:2016-11-01 00:00:00

  • Autism and Schizophrenia: Intestinal Disorders.

    abstract::We examined Dohan's hypothesis that schizophrenia is associated with the absorption of "exorphins" contained in gluten and casein. In addition, because of the work of Reichelt et al. (Reichelt, K.L., Saelid, G., Lindback, J. and Orbeck, H. (1986) Biological Psychiatry 21:1279-1290) and Rodriguez et al. (Rodriguez, Tra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Cade R,Privette M,Fregly M,Rowland N,Sun Z,Zele V,Wagemaker H,Edelstein C

    更新日期:2000-01-01 00:00:00

  • Feeding patterns and meal microstructure during development of a taste aversion to a threonine devoid diet.

    abstract::Food intake decreases and a conditioned taste aversion is induced when rats are fed a diet that is devoid of an indispensable amino acid. The purpose of this study was to characterize the meal patterns associated with (1) the onset of anorexia after the initial recognition of a threonine deficiency and (2) after the d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Feurté S,Tomé D,Gietzen DW,Even PC,Nicolaïdis S,Fromentin G

    更新日期:2002-09-01 00:00:00

  • Association of blood antioxidants status with visual and auditory sustained attention.

    abstract:OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Shiraseb F,Siassi F,Sotoudeh G,Qorbani M,Rostami R,Sadeghi-Firoozabadi V,Narmaki E

    更新日期:2015-01-01 00:00:00

  • Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats.

    abstract::Objective: We evaluate whether the consumption of fructose for 8 weeks affects enzymes and transcription factors of the lipogenic and inflammatory pathways in the hypothalamus of Wistar rats. Methods: At 30 days, the animals were divided into groups: Control (C) and Fructose (F) and maintained with free access to feed...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Batista LO,Ramos VW,Rosas Fernández MA,Concha Vilca CM,Albuquerque KT

    更新日期:2019-09-01 00:00:00

  • Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide.

    abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Spohr L,Luduvico KP,Soares MSP,Bona NP,Oliveira PS,de Mello JE,Alvez FL,Teixeira FC,Felix AOC,Stefanello FM,Spanevello RM

    更新日期:2020-09-21 00:00:00

  • Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.

    abstract::Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Tomonaga S,Hayakawa T,Yamane H,Maemura H,Sato M,Takahata Y,Morimatsu F,Furuse M

    更新日期:2007-06-01 00:00:00

  • Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers.

    abstract::The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,评审


    authors: Rosales FJ,Reznick JS,Zeisel SH

    更新日期:2009-10-01 00:00:00

  • A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological syndrome.

    abstract:OBJECTIVE:To evaluate cognitive functions and behavioral changes in the patients with vitamin B12 deficiency neurological syndromes (VBDNS) using detailed clinical psychometric and P3 studies and their response to treatment. METHODS:The patients with VBDNS were included and their detailed medical history was recorded...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Kalita J,Agarwal R,Chandra S,Misra UK

    更新日期:2013-01-01 00:00:00

  • No association between cognitive achievements, academic performance and serum cholesterol concentrations among school-aged children.

    abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Perry LA,Stigger CB,Ainsworth BE,Zhang J

    更新日期:2009-08-01 00:00:00

  • Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

    abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Vadnal R

    更新日期:1998-01-01 00:00:00

  • Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats.

    abstract:OBJECTIVES:Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model. METHODS:The rats were divided into control group received just...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohammadpour T,Hosseini M,Naderi A,Karami R,Sadeghnia HR,Soukhtanloo M,Vafaee F

    更新日期:2015-10-01 00:00:00