Abstract：
OBJECTIVES:To explore the association between dietary factors including fat, fruit and vegetable intake, dairy and meat consumption, and health-related quality of life (HRQOL), disability and relapse rate in a large international sample of people with multiple sclerosis (MS). METHODS:Participants with MS were recruited to the study via Web 2.0 platforms and completed a comprehensive survey measuring demographic and clinical characteristics, HRQOL, disability, relapse rate, and the Diet Habits Questionnaire (DHQ). RESULTS:Of 2469 participants with confirmed MS, 2087 (84.5%) provided complete data on their dietary habits (DHQ total score). Multivariate regression models demonstrated that every 10-point increase on the DHQ total score was associated with nearly a six-point and five-point increase in physical and mental HRQOL, respectively, and 30.0% reduced likelihood of a higher level of disability. After controlling for age and gender, and the other dietary covariates, 'healthy' consumption of fruit and vegetables and dietary fat predicted better quality of life and less likelihood of higher disability when compared to respondents with a 'poor' diet. For those with relapsing-remitting MS, the DHQ total significantly predicted a lower relapse rate and reduced odds of increasing disease activity, but the model fit was poor and the predicted change only marginal. DISCUSSION:This study supports significant associations of healthy dietary habits with better physical and mental HRQOL and a lower level of disability. Further research is urgently required to explore these associations including randomized controlled trials of dietary modification for people with MS.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Hadgkiss EJ,Jelinek GA,Weiland TJ,Pereira NG,Marck CH,van der Meer DMdoi
10.1179/1476830514Y.0000000117subject
Has Abstractpub_date
2015-04-01 00:00:00pages
125-36issue
3eissn
1028-415Xissn
1476-8305journal_volume
18pub_type
杂志文章abstract：:Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1468535
更新日期：2020-01-01 00:00:00
abstract：:The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683010X12611460764246
更新日期：2010-08-01 00:00:00
abstract：:Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for AS...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1557385
更新日期：2020-10-01 00:00:00
abstract：:Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the off...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747258
更新日期：1999-01-01 00:00:00
abstract：:Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1794422
更新日期：2020-07-20 00:00:00
abstract：:The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747269
更新日期：1999-01-01 00:00:00
abstract：:Objective: Although dietary patterns have been evaluated in relation to psychological disorders, their associations with psychosomatic complaints are unclear. We investigated relations of dietary patterns with psychosomatic complaints profiles.Methods: In this cross-sectional study, a total of 3363 adults were include...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1485611
更新日期：2020-03-01 00:00:00
abstract：:Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1815330
更新日期：2020-09-11 00:00:00
abstract：:Objectives: Unfavorable lactation influences brain excitability and behavioral reactions in adults. Administration early in life of the cholinergic agonist, pilocarpine, even at non-convulsive doses, alters the brain excitability-related phenomenon known as cortical spreading depression (CSD), and produce anxiogenic-l...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1819103
更新日期：2020-09-11 00:00:00
abstract：:Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1863740
更新日期：2020-12-29 00:00:00
abstract：:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651104
更新日期：2019-08-16 00:00:00
abstract：:Background/aim: Vitamin D has been hypothesized to be main regulator of the aging rate, alongside evidences support its role in neuroprotection. However, data about the protective role of vitamin D against neurophysiologic alterations associated with brain aging is limited. This study investigated the possible protect...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1665854
更新日期：2019-09-16 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effects of protein malnutrition during pregnancy on maternal behavior, on the early behavior in pups by ultrasonic vocalizations (USVs) emission, and on the behavior of offspring in adulthood in an elevated T-maze. METHODS:Pregnant female rats were fed a normal prote...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1177320
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:It has been shown that calcitriol and all-trans retinoic acid (ATRA) have modulatory effects on the immune system. The present study investigates the synergistic effects of combination treatment of calcitriol and ATRA in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1263039
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:The aim of the present study is to investigate the effects of topiramate on the fat mass/obesity-associated protein (FTO) and on the neuropeptide Y (NPY) level in the hypothalamus depending on the recently increased prevalence of obesity. METHOD:In this study, twenty-four female rats were divided into four e...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2017.1374033
更新日期：2019-04-01 00:00:00
abstract：:Objectives: Postpartum depression (PPD) is a major depressive disorder. Vitamin D deficiency may play a role in PPD pathogenesis. This study was designed to determine the effect of vitamin D and calcium supplementation on the severity of symptoms and some related inflammatory biomarkers in women with PPD.Materials and...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1707396
更新日期：2020-01-03 00:00:00
abstract：OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830511Y.0000000023
更新日期：2012-01-01 00:00:00
abstract：:The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X388850
更新日期：2009-02-01 00:00:00
abstract：:Objectives: Apigenin is the most common bioflavonoid known to be biologically active after systemic administration and show multiple pharmacological effects. The present study was designed to explore the role of apigenin in pentylenetetrazole (PTZ) kindling associated cognitive and behavioural impairments in the mouse...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1478653
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:Alzheimer's disease (AD) is one of the most common forms of neurodegenerative diseases. Despite vast ongoing researches focusing on the area, little is known about novel treatments. In this study, we aimed to survey the effects of Capparis spinosa (C. spinosa) extract on amyloid-beta peptide (Aβ)-injected ra...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1238026
更新日期：2018-02-01 00:00:00
abstract：:Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415031000111273
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:This study was designed to review the effect of chronic aluminium exposure on interleukin-6 (IL-6) secretion in the posterior brain and test the putative modulating effect of fenugreek seeds. METHODS:Female Wistar rats were divided into four groups: control; AlCl3 during 5 months (500 mg/kg body weight, intr...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830512Y.0000000048
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1871212
更新日期：2021-01-23 00:00:00
abstract：:Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1584692
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model. METHODS:The rats were divided into control group received just...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830514Y.0000000137
更新日期：2015-10-01 00:00:00
abstract：:Objectives: This study was designed to investigate the vitamin A (VA) and vitamin D (VD) levels in children with autism spectrum disorders (ASD) and to determine whether co-deficiency of VA and VD exacerbates clinical symptoms in autistic children. Methods: The Autism Behavior Checklist, Childhood Autism Rating Scale ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2017.1423268
更新日期：2019-09-01 00:00:00
abstract：:Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830510Y.0000000001
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:Coenzyme Q10 (CoQ10, ubiquinone) stands among the safest supplements in the elderly to protect against cardiovascular disorders. Noteworthy, CoQ10 deficiency is common in many surviving stroke patients as they are mostly prescribed statins for the secondary prevention of stroke incidence lifelong. Accordingl...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2017.1376928
更新日期：2019-04-01 00:00:00
abstract：:The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X423328
更新日期：2009-08-01 00:00:00
abstract：:Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic op...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,评审
doi：10.1080/1028415X.2016.1236174
更新日期：2018-02-01 00:00:00
