Early postnatal protein malnutrition causes resistance to the anxiolytic effects of diazepam as assessed by the fear-potentiated startle test.

Abstract:

:Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wistar rats (n = 110) from well-nourished (16 %-protein) or malnourished (6%-protein) litters were distributed in five different groups: W (well-nourished), M7 (malnourished for 7-days, since day 0), M14 (14-days), M21 (21-days) and M28 (28-days). The results obtained in FPS revealed that malnourished-animals acquired the startle response, irrespective of the time they were exposed to the diet. Besides, DZ reduced the startle amplitude in the noise-alone and light-noise trials. The data concerning the total freezing time showed that the expression of this response was affected by malnutrition and varied in accordance with the findings of previous studies in which malnutrition procedures was imposed for long periods (more than 50 days). Therefore, we suggest that early protein malnutrition: (a) did not produce deficits in the associative learning process of these animals in the FPS, and (b) decreased freezing time in the FPS and produce hyporeactivity to the effects of DZ in rats malnourished for 21 days or more, indicating alterations in the GABAergic neurotransmitter system.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Françolin-Silva AL,Brandão ML,Almeida SS

doi

10.1080/10284150601168346

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

23-9

issue

1-2

eissn

1028-415X

issn

1476-8305

journal_volume

10

pub_type

杂志文章
  • Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids.

    abstract:PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1180859

    authors: Abdel-Maksoud SM,Hassanein SI,Gohar NA,Attia SMM,Gad MZ

    更新日期:2017-10-01 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

    abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000151

    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

    更新日期:2016-01-01 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Differential Effects of Prenatal Protein Malnutrition and Prenatal Cocaine on Radial Arm Maze Performance in Adult Male Rats.

    abstract::The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747269

    authors: Shumsky JS,Shultz PL,Galler JR,Tonkiss J

    更新日期:1999-01-01 00:00:00

  • Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress.

    abstract::To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683010X12611460763481

    authors: Kurauchi I,Shigemi K,Kabuki Y,Hamasu K,Yamane H,Aoki M,Kawada Y,Morishita K,Denbow DM,Furuse M

    更新日期:2010-02-01 00:00:00

  • Adherence to a Mediterranean diet is associated with cognitive function in an older non-Mediterranean sample: findings from the Maine-Syracuse Longitudinal Study.

    abstract::Background: Adherence to a Mediterranean diet is associated with higher cognitive function and reduced risk of dementia in Mediterranean populations. However, few studies have investigated the association between Mediterranean diet adherence and cognition in populations outside of the Mediterranean basin. Furthermore,...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1655201

    authors: Wade AT,Elias MF,Murphy KJ

    更新日期:2019-08-21 00:00:00

  • Infant iron deficiency, iron supplementation, and psychosocial stress as predictors of neurocognitive development in Chilean adolescents.

    abstract::Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1651105

    authors: Doom JR,Gahagan S,Caballero G,Encina P,Lozoff B

    更新日期:2019-08-09 00:00:00

  • A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.

    abstract::We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/110284150600955164

    authors: Iwasaki Y,Morita A,Iwasawa T,Kobata K,Sekiwa Y,Morimitsu Y,Kubota K,Watanabe T

    更新日期:2006-06-01 00:00:00

  • Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene expression in chicks.

    abstract:OBJECTIVE:The objective of this study was to determine the influence of dietary macronutrient composition on central NPY's orexigenic effect in chicks. METHODS:Day-of-hatch chicks were fed one of three diets (3000 kcal ME/kg) ad libitum from hatch: high carbohydrate (HC), high fat (HF; 30% ME derived from soybean oil)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2017.1296606

    authors: McConn BR,Cline MA,Gilbert ER

    更新日期:2018-07-01 00:00:00

  • Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra.

    abstract:PURPOSE:The Mediterranean diet has been postulated as a protective factor against different diseases including stroke. Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovas...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150290007047

    authors: Martínez-González MA,Sanchez-Villegas A,De Irala J,Marti A,Martínez JA

    更新日期:2002-02-01 00:00:00

  • Is the maturation of monosynaptic stretch reflex in rats affected by neonatal malnutrition?

    abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X344138

    authors: Freitas-Silva SR,Manhães-de-Castro R,Pérot C

    更新日期:2008-10-01 00:00:00

  • Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.

    abstract::Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415042000198807

    authors: D'Anci KE,Kanarek RB

    更新日期:2004-02-01 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1468535

    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Iodine Deficiency and the Brain.

    abstract::The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747292

    authors: Hetzel BS

    更新日期:1999-01-01 00:00:00

  • Lactobacillus helveticus-fermented milk improves learning and memory in mice.

    abstract:OBJECTIVES:To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. METHODS:We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learni...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000122

    authors: Ohsawa K,Uchida N,Ohki K,Nakamura Y,Yokogoshi H

    更新日期:2015-07-01 00:00:00

  • Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse.

    abstract::Introduction: Phytoestrogens are non-steroidal estrogen analogues and are found primarily in soy products. They have received increasing attention as dietary supplements for estrogen deficiency and as modulators of endogenous estrogen functions, including cognition and emotion. In addition to modifying the levels of c...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1698826

    authors: Çalışkan G,Raza SA,Demiray YE,Kul E,Sandhu KV,Stork O

    更新日期:2019-12-09 00:00:00

  • Caffeine and energy drink use by combat arms soldiers in Afghanistan as a countermeasure for sleep loss and high operational demands.

    abstract:OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1443996

    authors: McLellan TM,Riviere LA,Williams KW,McGurk D,Lieberman HR

    更新日期:2019-11-01 00:00:00

  • No association between cognitive achievements, academic performance and serum cholesterol concentrations among school-aged children.

    abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X423328

    authors: Perry LA,Stigger CB,Ainsworth BE,Zhang J

    更新日期:2009-08-01 00:00:00

  • Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells.

    abstract:OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830512Y.0000000020

    authors: Chen JC,Liu KS,Yang TJ,Hwang JH,Chan YC,Lee IT

    更新日期:2012-11-01 00:00:00

  • Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus.

    abstract::Objectives: Apigenin is the most common bioflavonoid known to be biologically active after systemic administration and show multiple pharmacological effects. The present study was designed to explore the role of apigenin in pentylenetetrazole (PTZ) kindling associated cognitive and behavioural impairments in the mouse...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1478653

    authors: Sharma P,Sharma S,Singh D

    更新日期:2020-02-01 00:00:00

  • Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats.

    abstract::Depression is a major public health problem affecting about 12% of the world population. Drugs exist but they have many side effects. In the last few years, natural substances (e.g. flavonoids) have been tested to cure such disorders. Cocoa polyphenolic extract is a complex compound prepared from non-roasted cocoa bea...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X344165

    authors: Messaoudi M,Bisson JF,Nejdi A,Rozan P,Javelot H

    更新日期:2008-12-01 00:00:00

  • Feeding patterns and meal microstructure during development of a taste aversion to a threonine devoid diet.

    abstract::Food intake decreases and a conditioned taste aversion is induced when rats are fed a diet that is devoid of an indispensable amino acid. The purpose of this study was to characterize the meal patterns associated with (1) the onset of anorexia after the initial recognition of a threonine deficiency and (2) after the d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150290032003

    authors: Feurté S,Tomé D,Gietzen DW,Even PC,Nicolaïdis S,Fromentin G

    更新日期:2002-09-01 00:00:00

  • Interactive Effects of Neurochemicals on Ingestive Behavior.

    abstract::Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747313

    authors: Roth JD,Rowland NE

    更新日期:2000-01-01 00:00:00

  • The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis.

    abstract:OBJECTIVES:It has been shown that calcitriol and all-trans retinoic acid (ATRA) have modulatory effects on the immune system. The present study investigates the synergistic effects of combination treatment of calcitriol and ATRA in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1263039

    authors: Parastouei K,Mirshafiey A,Eshraghian MR,Shiri-Shahsavar MR,Solaymani-Mohammadi F,Chahardoli R,Alvandi E,Saboor-Yaraghi AA

    更新日期:2018-04-01 00:00:00

  • Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).

    abstract::Background/aim: Vitamin D has been hypothesized to be main regulator of the aging rate, alongside evidences support its role in neuroprotection. However, data about the protective role of vitamin D against neurophysiologic alterations associated with brain aging is limited. This study investigated the possible protect...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1665854

    authors: Khairy EY,Attia MM

    更新日期:2019-09-16 00:00:00

  • The Effect of Centrally Administered Glibenclamide, Tolbutamide and Diazoxide on Feeding in Rats.

    abstract::While there are many theories on the control of feeding behavior that emphasize a role for energy substrates and their metabolism, the mechanism that couples changes in energy substrate supply and metabolism to alterations in food intake remains unclear. The purpose of the present project was to investigate the possib...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747274

    authors: Bounds JK,Adloo AA,Harp PR,Olivier K,Roane DS

    更新日期:1999-01-01 00:00:00

  • Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers--a randomized crossover study.

    abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000018

    authors: Zimmermann-Viehoff F,Thayer J,Koenig J,Herrmann C,Weber CS,Deter HC

    更新日期:2016-05-01 00:00:00

  • Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide.

    abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1819104

    authors: Spohr L,Luduvico KP,Soares MSP,Bona NP,Oliveira PS,de Mello JE,Alvez FL,Teixeira FC,Felix AOC,Stefanello FM,Spanevello RM

    更新日期:2020-09-21 00:00:00

  • Improved cognitive-cerebral function in older adults with chromium supplementation.

    abstract::Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/147683010X12611460764084

    authors: Krikorian R,Eliassen JC,Boespflug EL,Nash TA,Shidler MD

    更新日期:2010-06-01 00:00:00

  • Effects of Noise-Induced Arousal on Chewing of Sweet Food and the Subjective Motivation to Eat.

    abstract::The effects of noise-induced arousal on chewing, subjective motivation to eat, the pleasantness of sweet food, and food intake were investigated. Twenty-four healthy normal weight male subjects received cookies differing in sucrose content (2%, 11%, 18% or 27%) before, during, and after 10 min of intermittent white no...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747231

    authors: Macht M

    更新日期:1998-01-01 00:00:00