Abstract：
:Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes. We sought to assess whether supplementation with Cr might improve memory and neural function in older adults with cognitive decline. In a placebo-controlled, double-blind trial, we randomly assigned 26 older adults to receive either chromium picolinate (CrPic) or placebo for 12 weeks. Memory and depression were assessed prior to treatment initiation and during the final week of treatment. We also performed functional magnetic resonance imaging (fMRI) scans on a subset of subjects. Although learning rate and retention were not enhanced by CrPic supplementation, we observed reduced semantic interference on learning, recall, and recognition memory tasks. In addition, fMRI indicated comparatively increased activation for the CrPic subjects in right thalamic, right temporal, right posterior parietal, and bifrontal regions. These findings suggest that supplementation with CrPic can enhance cognitive inhibitory control and cerebral function in older adults at risk for neurodegeneration.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Krikorian R,Eliassen JC,Boespflug EL,Nash TA,Shidler MDdoi
10.1179/147683010X12611460764084subject
Has Abstractpub_date
2010-06-01 00:00:00pages
116-22issue
3eissn
1028-415Xissn
1476-8305journal_volume
13pub_type
杂志文章,随机对照试验abstract：:Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). One type of mitochondrial decay is oxidative modification of key mitochondrial enzymes. Enzyme dysfunction, that is due to poor binding ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,评审
doi：10.1080/10284150500047161
更新日期：2005-04-01 00:00:00
abstract：:To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683010X12611460763481
更新日期：2010-02-01 00:00:00
abstract：:The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747212
更新日期：1998-01-01 00:00:00
abstract：:Sensory awareness contributes to the enjoyment of eating and drinking. This study tested the hypothesis that changes in the intensity of oral sensations could be used to regulate the volume of intake. Forty women (< 36 years) volunteered. The participants consumed distilled water, salt water and two concentrations of ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150500449029
更新日期：2005-08-01 00:00:00
abstract：:Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651105
更新日期：2019-08-09 00:00:00
abstract：:Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2000.11747313
更新日期：2000-01-01 00:00:00
abstract：:Adult female rats, receiving a low protein diet at perinatal age and then recovered with balanced chow (D rats), were evaluated in the Open Field Drink Test (OFDT), after different acute and chronic treatments with benzodiazepines (BZD) ligands, as compared with control (C) female rats. Control and D rats showed simil...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747253
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000032
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1203125
更新日期：2017-11-01 00:00:00
abstract：:Background and objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which no treatments exist. Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the most frequent monogenic cause of ASD. Given the lack of pharmacological treatments for ASD, increasin...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1819107
更新日期：2020-09-11 00:00:00
abstract：:Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830510Y.0000000001
更新日期：2011-03-01 00:00:00
abstract：RATIONALE:Recent research suggests that chewing gum may increase alertness and lead to changes in cognitive performance. The present study examined effects of chewing gum on these functions within the context of a single study. OBJECTIVES:This study had four main aims. The first was to examine whether chewing gum impr...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X423247
更新日期：2009-04-01 00:00:00
abstract：:The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X388850
更新日期：2009-02-01 00:00:00
abstract：:The aim of this study was to examine the function of the lateral parabrachial area (LPB) in relation to the intragastric administration of nutrients. The consumption of flavors associated with intragastric nutrient administration and the subsequent food and water intake were measured in rats with lesions in the LPB. T...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150600576655
更新日期：2005-10-01 00:00:00
abstract：PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1180859
更新日期：2017-10-01 00:00:00
abstract：:This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in n...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683008X301522
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1443996
更新日期：2019-11-01 00:00:00
abstract：:The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X423328
更新日期：2009-08-01 00:00:00
abstract：:Organophosphorus compounds are widely used in agriculture. Epidemiological studies propose that pesticide exposure is a risk factor for Alzheimer's disease (AD), but the mechanisms are unclear. Here, we investigated the impact of malathion exposure on the cognitive ability and the underlying mechanisms in rats. Moreov...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1492772
更新日期：2020-03-01 00:00:00
abstract：:A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...
journal_title：Nutritional neuroscience
pub_type： 信件
doi：10.1080/1028415X.2020.1728473
更新日期：2020-02-19 00:00:00
abstract：:We examined whether diabetes mellitus (DM) affects the acute ethanol (EtOH)-induced increase in serotonin (5-HT) release from the rat hippocampus, and compared the findings with those obtained from non-DM rats. Hippocampal 5-HT was measured by using in vivo microdialysis. Rats were rendered diabetic by an injection of...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830511Y.0000000006
更新日期：2011-05-01 00:00:00
abstract：:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651104
更新日期：2019-08-16 00:00:00
abstract：:While there are many theories on the control of feeding behavior that emphasize a role for energy substrates and their metabolism, the mechanism that couples changes in energy substrate supply and metabolism to alterations in food intake remains unclear. The purpose of the present project was to investigate the possib...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747274
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVES:Sodium metabisulfite as a food preservative can affect the central nervous system. Curcumin, the main ingredient of turmeric has neuroprotective activity. This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods. METHODS:Thirt...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830514Y.0000000123
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000033
更新日期：2016-06-01 00:00:00
abstract：:This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150412331281031
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830512Y.0000000020
更新日期：2012-11-01 00:00:00
abstract：:Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water ma...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150701722158
更新日期：2007-10-01 00:00:00
abstract：:Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150601168346
更新日期：2007-02-01 00:00:00
abstract：:We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/110284150600955164
更新日期：2006-06-01 00:00:00
