Abstract：
:We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1. In this regard, the shogaols were more potent than the gingerols. Aversive responses were induced by [6]-, [10]-gingerol, and [6]-shogaol (5 mmol/l) in rats when these compounds were applied to the eye; however, no response was observed in response to [10]-shogaol (5 and 10 mmol/l). [10]-Shogaol induced nociceptive responses via TRPV1 in rats following its subcutaneous injection into the hindpaw; the pungent compound capsaicin (CAP) and [6]-shogaol were observed to have similar effects. Moreover, adrenal catecholamine secretion, which influences energy consumption, was promoted in rats in response to [6]- and [10]-gingerols and [6]- and [10]-shogaols (1.6 micromol/kg, i.v.). [10]-Shogaol-induced adrenaline secretion was inhibited by administration of capsazepine, a TRPV1 antagonist. In conclusion, gingerols and shogaols activated TRPV1 and increased adrenaline secretion. Interestingly, [10]-shogaol is the only nonpungent compound among the gingerols and shogaols, suggesting its usefulness as a functional ingredient in food.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Iwasaki Y,Morita A,Iwasawa T,Kobata K,Sekiwa Y,Morimitsu Y,Kubota K,Watanabe Tdoi
10.1080/110284150600955164subject
Has Abstractpub_date
2006-06-01 00:00:00pages
169-78issue
3-4eissn
1028-415Xissn
1476-8305journal_volume
9pub_type
杂志文章abstract：:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651104
更新日期：2019-08-16 00:00:00
abstract：:The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747212
更新日期：1998-01-01 00:00:00
abstract：:Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415042000198807
更新日期：2004-02-01 00:00:00
abstract：:Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1815330
更新日期：2020-09-11 00:00:00
abstract：:This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150412331281031
更新日期：2004-06-01 00:00:00
abstract：:Background: Alzheimer's disease is known as one of the fastest growing lethal diseases worldwide where we have limited and undesired ways for regulating its pathological progress. Now-a-days, nutritional compounds have been using to treat several brain disorders and one of them; vitamins were strongly reported to comb...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1826762
更新日期：2020-10-01 00:00:00
abstract：:Objective: Amylin acts on the lateral dorsal tegmental nucleus (LDT), resulting in anorexic and weight-loss effects and activates thermogenesis in the interscapular brown adipose tissue (IBAT). In addition, it induces neuronal nitric oxide synthase (nNOS) and choline acetyltransferase (ChAT)-mediated feeding. However,...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1752998
更新日期：2020-04-25 00:00:00
abstract：:Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water ma...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150701722158
更新日期：2007-10-01 00:00:00
abstract：:The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747241
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2015.1123378
更新日期：2017-06-01 00:00:00
abstract：:The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747269
更新日期：1999-01-01 00:00:00
abstract：:The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2000.11747309
更新日期：2000-01-01 00:00:00
abstract：:Sensory awareness contributes to the enjoyment of eating and drinking. This study tested the hypothesis that changes in the intensity of oral sensations could be used to regulate the volume of intake. Forty women (< 36 years) volunteered. The participants consumed distilled water, salt water and two concentrations of ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150500449029
更新日期：2005-08-01 00:00:00
abstract：:Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects...
journal_title：Nutritional neuroscience
pub_type： 临床试验,杂志文章
doi：10.1080/1028415x.2001.11747356
更新日期：2001-01-01 00:00:00
abstract：:The effects of perinatal undernutrition on the number of neurons and apoptotic cells of the locus coeruleus (LC) of female and male rats at postpartum days 7, 12, 20, 30 and 60 were studied. Undernutrition reduces the number of neurons in both sexes without affecting cell death, as indicated by the ratio of apoptotic ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150600937873
更新日期：2006-10-01 00:00:00
abstract：:Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1794422
更新日期：2020-07-20 00:00:00
abstract：:Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150601168346
更新日期：2007-02-01 00:00:00
abstract：:Objectives: This study was designed to investigate the vitamin A (VA) and vitamin D (VD) levels in children with autism spectrum disorders (ASD) and to determine whether co-deficiency of VA and VD exacerbates clinical symptoms in autistic children. Methods: The Autism Behavior Checklist, Childhood Autism Rating Scale ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2017.1423268
更新日期：2019-09-01 00:00:00
abstract：:Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651105
更新日期：2019-08-09 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS:The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical work...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1179/1476830515Y.0000000023
更新日期：2016-11-01 00:00:00
abstract：:Objective: We evaluate whether the consumption of fructose for 8 weeks affects enzymes and transcription factors of the lipogenic and inflammatory pathways in the hypothalamus of Wistar rats. Methods: At 30 days, the animals were divided into groups: Control (C) and Fructose (F) and maintained with free access to feed...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1427659
更新日期：2019-09-01 00:00:00
abstract：:Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding shou...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150400012794
更新日期：2004-08-01 00:00:00
abstract：:Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox home...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1501532
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1443996
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:To explore the association between dietary factors including fat, fruit and vegetable intake, dairy and meat consumption, and health-related quality of life (HRQOL), disability and relapse rate in a large international sample of people with multiple sclerosis (MS). METHODS:Participants with MS were recruite...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830514Y.0000000117
更新日期：2015-04-01 00:00:00
abstract：:Organophosphorus compounds are widely used in agriculture. Epidemiological studies propose that pesticide exposure is a risk factor for Alzheimer's disease (AD), but the mechanisms are unclear. Here, we investigated the impact of malathion exposure on the cognitive ability and the underlying mechanisms in rats. Moreov...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1492772
更新日期：2020-03-01 00:00:00
abstract：:In this article, the second of a series on the analysis of time to event data, we address the case in which multiple predictors (covariates) that may influence the time to an event are taken into account. The hazard function is introduced, and is given in a form useful for assessing the impact of multiple covariates o...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415031000079694
更新日期：2003-04-01 00:00:00
abstract：:The effects of noise-induced arousal on chewing, subjective motivation to eat, the pleasantness of sweet food, and food intake were investigated. Twenty-four healthy normal weight male subjects received cookies differing in sucrose content (2%, 11%, 18% or 27%) before, during, and after 10 min of intermittent white no...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747231
更新日期：1998-01-01 00:00:00
abstract：:The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1999.11747292
更新日期：1999-01-01 00:00:00
abstract：:Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor per...
journal_title：Nutritional neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/1028415031000120552
更新日期：2003-08-01 00:00:00
