Abstract：
:Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects were 120 elderly (> 57 years) of both sexes who fulfilled the more stringent criteria for age-associated memory impairment (AAMI); some also fulfilled the criteria for age-associated cognitive decline. Subjects were allocated at random to one of the three treatment groups: placebo, 300mg S-PS daily, or 600mg S-PS daily. Assessments were carried out at baseline, after 6 and 12 weeks of treatment, and after a wash-out period of 3 weeks. Tests of learning and memory, choice reaction time, planning and attentional functions were administered at each assessment. Delayed recall and recognition of a previously learned word list comprised the primary outcome measures. No significant differences were found in any of the outcome variables between the treatment groups. There were also no significant interactions between treatment and 'severity of memory complaints'. In conclusion, a daily supplement of S-PS does not affect memory or other cognitive functions in older individuals with memory complaints.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Jorissen BL,Brouns F,Van Boxtel MP,Ponds RW,Verhey FR,Jolles J,Riedel WJdoi
10.1080/1028415x.2001.11747356keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
121-34issue
2eissn
1028-415Xissn
1476-8305journal_volume
4pub_type
临床试验,杂志文章abstract：:Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1179/147683010X12611460764084
更新日期：2010-06-01 00:00:00
abstract：:Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150701587338
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1443996
更新日期：2019-11-01 00:00:00
abstract：:We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/110284150600955164
更新日期：2006-06-01 00:00:00
abstract：:The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683009X423328
更新日期：2009-08-01 00:00:00
abstract：:Objectives: Postpartum depression (PPD) is a major depressive disorder. Vitamin D deficiency may play a role in PPD pathogenesis. This study was designed to determine the effect of vitamin D and calcium supplementation on the severity of symptoms and some related inflammatory biomarkers in women with PPD.Materials and...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1707396
更新日期：2020-01-03 00:00:00
abstract：:Background: This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders.Materials & Methods: A total of 88 subjects (64 women and 24 men,...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2020.1752997
更新日期：2020-04-15 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS:The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical work...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1179/1476830515Y.0000000023
更新日期：2016-11-01 00:00:00
abstract：:The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.1998.11747212
更新日期：1998-01-01 00:00:00
abstract：:Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150601168346
更新日期：2007-02-01 00:00:00
abstract：:Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormal development of cognitive, social, and communicative skills. Although ASD aetiology and pathophysiology are still unclear, various nutritional factors have been investigated as potential risk factors for AS...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2018.1557385
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here, we analyze whether the early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters i...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000012
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:The green seaweed Ulva sp. contains a large amount of ulvans, a family of sulphated polysaccharides. The present study was designed to investigate in rats the antidepressant- and anxiolytic-like effects of a hydrophilic extract of Ulva sp. (MSP) containing about 45% of ulvans. METHODS:After a 14-day adminis...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1276704
更新日期：2018-05-01 00:00:00
abstract：:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus t...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2019.1651104
更新日期：2019-08-16 00:00:00
abstract：:Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415x.2001.11747364
更新日期：2001-01-01 00:00:00
abstract：:Moderately low-protein diets lead to a rapid increase in food intake and body fat. The increase in feeding is associated with a decrease in the concentration of serum urea nitrogen, suggesting that the low-protein-induced increase in food intake may be related to the decreased metabolism of nitrogen from amino acids. ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150310001640365
更新日期：2003-12-01 00:00:00
abstract：:Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic op...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,评审
doi：10.1080/1028415X.2016.1236174
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:The aim of the present study is to investigate the effects of topiramate on the fat mass/obesity-associated protein (FTO) and on the neuropeptide Y (NPY) level in the hypothalamus depending on the recently increased prevalence of obesity. METHOD:In this study, twenty-four female rats were divided into four e...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2017.1374033
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:Genistein is a plant-derived estrogenic isoflavone commonly found in dietary and therapeutic supplements, due to its potential health benefits. Growth hormone-releasing hormone (GHRH) and somatostatin (SS) are neurosecretory peptides synthesized in neurons of the hypothalamus and regulate the growth hormone ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830514Y.0000000143
更新日期：2016-12-01 00:00:00
abstract：:This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in n...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/147683008X301522
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1203125
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000006
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:A low antioxidants status has been shown to result in oxidative stress and cognitive impairment. Because antioxidants can protect the nervous system, it is expected that a better blood antioxidant status might be related to sustained attention. However, the relationship between the blood antioxidant status an...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830515Y.0000000032
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND AND RATIONALE:Certain nutritional supplements are being marketed for the management of Alzheimer's disease (AD), but the evidence for their effectiveness is not established. The objective of this review was to evaluate the evidence from randomized clinical trial (RCTs) examining the effect of Souvenaid in pa...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,meta分析,评审
doi：10.1080/1028415X.2015.1110899
更新日期：2017-05-01 00:00:00
abstract：:Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415031000111273
更新日期：2003-06-01 00:00:00
abstract：:Sensory awareness contributes to the enjoyment of eating and drinking. This study tested the hypothesis that changes in the intensity of oral sensations could be used to regulate the volume of intake. Forty women (< 36 years) volunteered. The participants consumed distilled water, salt water and two concentrations of ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150500449029
更新日期：2005-08-01 00:00:00
abstract：:Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). One type of mitochondrial decay is oxidative modification of key mitochondrial enzymes. Enzyme dysfunction, that is due to poor binding ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章,评审
doi：10.1080/10284150500047161
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1179/1476830512Y.0000000020
更新日期：2012-11-01 00:00:00
abstract：:Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG ...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/10284150500506042
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...
journal_title：Nutritional neuroscience
pub_type： 杂志文章
doi：10.1080/1028415X.2016.1180859
更新日期：2017-10-01 00:00:00
