Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

Abstract:

:Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 and 10 nmol apelin-12 or saline vehicle, 10 min prior to lights out, led to dose-dependent reductions in food intake 2-4 h after injection (n = 7; p < 0.05). This suggests that apelin-12 exerts a delayed inhibitory effect on nocturnal feeding. Relative to saline, no effect was observed on total 24-h food intake post injection. In contrast, day-time administration of 10 nmol apelin-12 to satiated rats stimulated feeding (n = 5-11; p < 0.05); lower doses had no effect. No changes in water intake were observed after apelin-12. These results suggest that apelin is involved in the central control of feeding.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

O'Shea M,Hansen MJ,Tatemoto K,Morris MJ

doi

10.1080/1028415031000111273

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

163-7

issue

3

eissn

1028-415X

issn

1476-8305

journal_volume

6

pub_type

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