Volume of the Sexually Dimorphic Nucleus of the Preoptic Area in Rats Exposed to a Maternal High Fat Diet.

Abstract:

:Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the offspring of female rats on a high, or low fat diet during pregnancy and nursing. The measurements showed that the SDN-POA was smaller in female offspring exposed to a maternal high fat diet than in female offspring exposed to a maternal low fat diet. This could result in endocrine disturbances and thus provide a possible explanation for the linkage between high fat exposure prenatally and increased female reproductive system cancer.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Walker BE

doi

10.1080/1028415X.1999.11747258

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

19-22

issue

1

eissn

1028-415X

issn

1476-8305

journal_volume

2

pub_type

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