Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection.

Abstract:

OBJECTIVES:Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study was to investigate the role of PUFAs on the development of somatic symptoms and depression in patients of hepatitis C virus infection (HCV) receiving interferon-alpha therapy (IFN-α) in a prospective manner. METHODS:In this 24-week, prospective cohort study, 43 patients with chronic HCV ongoing IFN-α therapy were assessed with the mini-international neuropsychiatric interview for major depressive episodes and neurotoxicity rating scale (NRS) for somatic symptoms. RESULTS:One-third later developed IFN-α-induced depression (depression (DEP) group). As compared to subjects without depression, DEP group had higher NRS scores (P < 0.001), lower eicosapentaenoic acid (EPA) levels (P = 0.038) at week 2. Somatic symptoms, regardless of painful/non-painful characteristics, had positive association with arachidonic acid (P < 0.05), and negative association with EPA (P < 0.05). CONCLUSION:This study implies that early intervention with omega-3 PUFAs might be a promising strategy to prevent depression and somatic symptoms in patients receiving cytokine therapy.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Chang JP,Lai HC,Yang HT,Su WP,Peng CY,Gałecki P,Walczewska A,Pariante CM,Su KP

doi

10.1080/1028415X.2015.1123378

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

291-296

issue

5

eissn

1028-415X

issn

1476-8305

journal_volume

20

pub_type

杂志文章
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    doi:10.1080/1028415031000111273

    authors: O'Shea M,Hansen MJ,Tatemoto K,Morris MJ

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  • Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

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    authors: Abdel-Maksoud SM,Hassanein SI,Gohar NA,Attia SMM,Gad MZ

    更新日期:2017-10-01 00:00:00

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

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    journal_title:Nutritional neuroscience

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    doi:10.1080/10284150500506042

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  • Low dietary protein is associated with an increase in food intake and a decrease in the in vitro release of radiolabeled glutamate and GABA from the lateral hypothalamus.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150310001640365

    authors: White BD,Du F,Higginbotham DA

    更新日期:2003-12-01 00:00:00

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    journal_title:Nutritional neuroscience

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    doi:10.1179/147683009X423328

    authors: Perry LA,Stigger CB,Ainsworth BE,Zhang J

    更新日期:2009-08-01 00:00:00

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    更新日期:2006-06-01 00:00:00

  • Brain activity and connectivity changes in response to nutritive natural sugars, non-nutritive natural sugar replacements and artificial sweeteners.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1639306

    authors: Van Opstal AM,Hafkemeijer A,van den Berg-Huysmans AA,Hoeksma M,Mulder TPJ,Pijl H,Rombouts SARB,van der Grond J

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  • Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1427659

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    更新日期:2019-09-01 00:00:00

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    journal_title:Nutritional neuroscience

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    authors: Nagata T,Nishiyama A,Yamato T,Obata T,Aomine M

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  • Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats.

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    journal_title:Nutritional neuroscience

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    更新日期:2020-09-11 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

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    journal_title:Nutritional neuroscience

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    doi:10.1179/1476830514Y.0000000151

    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

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  • Analyzing data in which the outcome is time to an event part II: The presence of multiple covariates.

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    journal_title:Nutritional neuroscience

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  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

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    journal_title:Nutritional neuroscience

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    doi:10.1080/1028415X.2018.1468535

    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

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  • Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population.

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  • The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers.

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    pub_type: 杂志文章,随机对照试验

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  • Interactive Effects of Neurochemicals on Ingestive Behavior.

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    pub_type: 杂志文章

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    doi:10.1080/1028415X.2019.1665854

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    authors: Macht M

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