Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress.

Abstract:

:To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of L-ornithine, putrescine, spermidine, spermine or saline (control). After injection, chicks were immediately separated from the flock and monitored for the number of distress vocalizations and various postures. L-Ornithine greatly attenuated the stress response and caused sedative and hypnotic effects. Among the polyamines, only putrescine attenuated distress vocalizations but did not induce sleep. In conclusion, the sedative and hypnotic effect of L-ornithine was mainly induced by L-ornithine itself, while the polyamines contributed to the sedative, but not hypnotic, effect under social separation stress.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Kurauchi I,Shigemi K,Kabuki Y,Hamasu K,Yamane H,Aoki M,Kawada Y,Morishita K,Denbow DM,Furuse M

doi

10.1179/147683010X12611460763481

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

17-20

issue

1

eissn

1028-415X

issn

1476-8305

journal_volume

13

pub_type

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