Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury.

Abstract:

:Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic options remain limited. Traditional pharmaceutical interventions have failed to transition to the clinic for the treatment of mild TBI. As such, many pre-clinical studies are now implementing non-pharmaceutical therapies for TBI. These studies have demonstrated promise, particularly those that modulate secondary injury cascades activated after injury. Because no TBI therapy has been discovered for mild injury, researchers now look to pharmaceutical supplementation in an attempt to foster success in human clinical trials. Non-traditional therapies, such as acupuncture and even music therapy are being considered to combat the neuropsychiatric symptoms of TBI. In this review, we highlight alternative approaches that have been studied in clinical and pre-clinical studies of TBI, and other related forms of neural injury. The purpose of this review is to stimulate further investigation into novel and innovative approaches that can be used to treat the mechanisms and symptoms of mild TBI.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Lucke-Wold BP,Logsdon AF,Nguyen L,Eltanahay A,Turner RC,Bonasso P,Knotts C,Moeck A,Maroon JC,Bailes JE,Rosen CL

doi

10.1080/1028415X.2016.1236174

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

79-91

issue

2

eissn

1028-415X

issn

1476-8305

journal_volume

21

pub_type

杂志文章,评审
  • Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse.

    abstract::Introduction: Phytoestrogens are non-steroidal estrogen analogues and are found primarily in soy products. They have received increasing attention as dietary supplements for estrogen deficiency and as modulators of endogenous estrogen functions, including cognition and emotion. In addition to modifying the levels of c...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1698826

    authors: Çalışkan G,Raza SA,Demiray YE,Kul E,Sandhu KV,Stork O

    更新日期:2019-12-09 00:00:00

  • Improved cognitive-cerebral function in older adults with chromium supplementation.

    abstract::Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/147683010X12611460764084

    authors: Krikorian R,Eliassen JC,Boespflug EL,Nash TA,Shidler MD

    更新日期:2010-06-01 00:00:00

  • Is the maturation of monosynaptic stretch reflex in rats affected by neonatal malnutrition?

    abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X344138

    authors: Freitas-Silva SR,Manhães-de-Castro R,Pérot C

    更新日期:2008-10-01 00:00:00

  • The effect of vitamin D and calcium supplementation on inflammatory biomarkers, estradiol levels and severity of symptoms in women with postpartum depression: a randomized double-blind clinical trial.

    abstract::Objectives: Postpartum depression (PPD) is a major depressive disorder. Vitamin D deficiency may play a role in PPD pathogenesis. This study was designed to determine the effect of vitamin D and calcium supplementation on the severity of symptoms and some related inflammatory biomarkers in women with PPD.Materials and...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1707396

    authors: Amini S,Amani R,Jafarirad S,Cheraghian B,Sayyah M,Hemmati AA

    更新日期:2020-01-03 00:00:00

  • Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells.

    abstract:OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830512Y.0000000020

    authors: Chen JC,Liu KS,Yang TJ,Hwang JH,Chan YC,Lee IT

    更新日期:2012-11-01 00:00:00

  • Inhibition of hormonal and behavioral effects of stress by tryptophan in rats.

    abstract:OBJECTIVES:Stress in known to alter hormonal systems. Pharmacological doses of tryptophan, the essential amino acid precursor of serotonin, increase circulating leptin and decrease ghrelin in normal healthy adults. Because systemically injected leptin inhibits stress-induced behavioral deficits and systemically injecte...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2017.1395551

    authors: Gul S,Saleem D,Haleem MA,Haleem DJ

    更新日期:2019-06-01 00:00:00

  • A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.

    abstract::A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...

    journal_title:Nutritional neuroscience

    pub_type: 信件

    doi:10.1080/1028415X.2020.1728473

    authors: Cortés-Álvarez NY,Vuelvas-Olmos CR,Pinto-González MF,Guzmán-Muñiz J,Gonzalez-Perez O,Moy-López NA

    更新日期:2020-02-19 00:00:00

  • Dietary patterns in relation with psychosomatic complaints profile: Results from SEPAHAN study among a large sample of general adults.

    abstract::Objective: Although dietary patterns have been evaluated in relation to psychological disorders, their associations with psychosomatic complaints are unclear. We investigated relations of dietary patterns with psychosomatic complaints profiles.Methods: In this cross-sectional study, a total of 3363 adults were include...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1485611

    authors: Haghighatdoost F,Feizi A,Esmaillzadeh A,Hassanzadeh Keshteli A,Roohafza H,Afshar H,Adibi P

    更新日期:2020-03-01 00:00:00

  • Sex-biased transgenerational transmission of betaine-induced epigenetic modifications in glucocorticoid receptor gene and its down-stream BDNF/ERK pathway in rat hippocampus.

    abstract::Objectives: Glucocorticoid receptor (GR) expressed in hippocampus is critical for the homeostasis of stress responses and susceptible to epigenetic modulation caused by maternal factors. Here we show that maternal methyl nutrition causes sex-biased changes in hippocampal expression of GR exon 1 mRNA variants, associat...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1807711

    authors: Yang Y,Yang S,Jia Y,Yin C,Zhao R

    更新日期:2020-08-25 00:00:00

  • Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers--a randomized crossover study.

    abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000018

    authors: Zimmermann-Viehoff F,Thayer J,Koenig J,Herrmann C,Weber CS,Deter HC

    更新日期:2016-05-01 00:00:00

  • A Saturated-Fat Diet during Development Alters Dendritic Growth in Mouse Brain.

    abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747212

    authors: Wainwright PE,Bulman-Fleming MB,Lévesque S,Mutsaers L,McCutcheon D

    更新日期:1998-01-01 00:00:00

  • Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense.

    abstract::Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1815330

    authors: Dos Santos E,Radai JAS,do Nascimento KF,Formagio ASN,de Matos Balsalobre N,Ziff EB,Castelon Konkiewitz E,Kassuya CAL

    更新日期:2020-09-11 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Beneficial effects of a protein free, high carbohydrate meal on rat coping behavior and neurotransmitter levels during heat stress.

    abstract::This study examined effects of a single protein-free (PROT-free), high carbohydrate meal (0% protein, 82% carbohydrate) or control meal (20% protein, 62% carbohydrate) on coping behavior and neurotransmitter levels of male Fischer 344 rats. Meals varying in protein/carbohydrate ratio differentially affect transport of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150400017330

    authors: Yeghiayan SK,Georgelis JH,Maher TJ,Lieberman HR

    更新日期:2004-10-01 00:00:00

  • Organization of olfactory glomeruli in neonatally undernourished rats.

    abstract::Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150500506042

    authors: Frias C,Torrero C,Regalado M,Salas M

    更新日期:2006-02-01 00:00:00

  • Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

    abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747241

    authors: Vadnal R

    更新日期:1998-01-01 00:00:00

  • Perspectives from the symposium: The role of nutrition in infant and toddler brain and behavioral development.

    abstract::This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in n...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X301522

    authors: Rosales FJ,Zeisel SH

    更新日期:2008-06-01 00:00:00

  • Caffeine and energy drink use by combat arms soldiers in Afghanistan as a countermeasure for sleep loss and high operational demands.

    abstract:OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1443996

    authors: McLellan TM,Riviere LA,Williams KW,McGurk D,Lieberman HR

    更新日期:2019-11-01 00:00:00

  • Early postnatal protein malnutrition causes resistance to the anxiolytic effects of diazepam as assessed by the fear-potentiated startle test.

    abstract::Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150601168346

    authors: Françolin-Silva AL,Brandão ML,Almeida SS

    更新日期:2007-02-01 00:00:00

  • Association of dietary patterns with systemic inflammation, quality of life, disease severity, relapse rate, severity of fatigue and anthropometric measurements in MS patients.

    abstract::Background: Multiple sclerosis (MS) is associated with changes in quality of life, disability, fatigue and anthropometric measurements. The important relationship of dietary patterns with such clinical manifestations was not completely investigated. Aims: The goal of this study was to define the dietary patterns and t...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1580831

    authors: Moravejolahkami AR,Paknahad Z,Chitsaz A

    更新日期:2020-12-01 00:00:00

  • The Effect of Centrally Administered Glibenclamide, Tolbutamide and Diazoxide on Feeding in Rats.

    abstract::While there are many theories on the control of feeding behavior that emphasize a role for energy substrates and their metabolism, the mechanism that couples changes in energy substrate supply and metabolism to alterations in food intake remains unclear. The purpose of the present project was to investigate the possib...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747274

    authors: Bounds JK,Adloo AA,Harp PR,Olivier K,Roane DS

    更新日期:1999-01-01 00:00:00

  • Effects of Noise-Induced Arousal on Chewing of Sweet Food and the Subjective Motivation to Eat.

    abstract::The effects of noise-induced arousal on chewing, subjective motivation to eat, the pleasantness of sweet food, and food intake were investigated. Twenty-four healthy normal weight male subjects received cookies differing in sucrose content (2%, 11%, 18% or 27%) before, during, and after 10 min of intermittent white no...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747231

    authors: Macht M

    更新日期:1998-01-01 00:00:00

  • Protective role of curcumin against sulfite-induced structural changes in rats' medial prefrontal cortex.

    abstract:OBJECTIVES:Sodium metabisulfite as a food preservative can affect the central nervous system. Curcumin, the main ingredient of turmeric has neuroprotective activity. This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods. METHODS:Thirt...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000123

    authors: Noorafshan A,Asadi-Golshan R,Abdollahifar MA,Karbalay-Doust S

    更新日期:2015-08-01 00:00:00

  • Association between des-acyl ghrelin at fasting and predictive index of muscle derangement, metabolic markers and eating disorders: a cross-sectional study in overweight and obese adults.

    abstract::Background: This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders.Materials & Methods: A total of 88 subjects (64 women and 24 men,...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1752997

    authors: Perna S,Spadaccini D,Gasparri C,Peroni G,Infantino V,Iannello G,Riva A,Petrangolini G,Alalwan TA,Al-Thawadi S,Rondanelli M

    更新日期:2020-04-15 00:00:00

  • Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids.

    abstract:PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1180859

    authors: Abdel-Maksoud SM,Hassanein SI,Gohar NA,Attia SMM,Gad MZ

    更新日期:2017-10-01 00:00:00

  • The effect of breakfast versus no breakfast on brain activity in adolescents when performing cognitive tasks, as assessed by fMRI.

    abstract:OBJECTIVES:The study examined the feasibility of utilizing functional magnetic resonance imaging (fMRI) with a group of adolescent boys and girls to assess modifications in cognitive function, dependent upon the nutritional state of the participants. METHODS:Twenty children aged 12-14 years completed two cognitive tri...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000011

    authors: Fulford J,Varley-Campbell JL,Williams CA

    更新日期:2016-01-01 00:00:00

  • The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment.

    abstract::Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1080/1028415x.2001.11747356

    authors: Jorissen BL,Brouns F,Van Boxtel MP,Ponds RW,Verhey FR,Jolles J,Riedel WJ

    更新日期:2001-01-01 00:00:00

  • Effects of chewing gum on mood, learning, memory and performance of an intelligence test.

    abstract:RATIONALE:Recent research suggests that chewing gum may increase alertness and lead to changes in cognitive performance. The present study examined effects of chewing gum on these functions within the context of a single study. OBJECTIVES:This study had four main aims. The first was to examine whether chewing gum impr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X423247

    authors: Smith A

    更新日期:2009-04-01 00:00:00

  • Autism and Schizophrenia: Intestinal Disorders.

    abstract::We examined Dohan's hypothesis that schizophrenia is associated with the absorption of "exorphins" contained in gluten and casein. In addition, because of the work of Reichelt et al. (Reichelt, K.L., Saelid, G., Lindback, J. and Orbeck, H. (1986) Biological Psychiatry 21:1279-1290) and Rodriguez et al. (Rodriguez, Tra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747303

    authors: Cade R,Privette M,Fregly M,Rowland N,Sun Z,Zele V,Wagemaker H,Edelstein C

    更新日期:2000-01-01 00:00:00

  • Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.

    abstract::The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683010X12611460764246

    authors: Miñana-Solis Mdel C,Angeles-Castellanos M,Buijs RM,Escobar C

    更新日期:2010-08-01 00:00:00