Brain Nrf2 pathway, autophagy, and synaptic function proteins are modulated by a short-term fructose feeding in young and adult rats.

Abstract:

:Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox homeostasis, autophagy and synaptic plasticity in the cortex of young and adults rats, in order to highlight the early risks to which brain is exposed.Methods and Results: Short-term fructose feeding was associated with an imbalance of redox homeostasis, as lower amount of Nuclear factor (erythroid derived 2)-like 2, lower activity of Glucose 6-phosphate dehydrogenase and Glutathione reductase, together with lower Glutathione/Oxidized Glutathione ratio, were found in fructose-fed young and adult rats. Fructose-rich diet was also associated with the activation of autophagy, as higher levels of Beclin, LC3 II and P62 were detected in cortex of fructose-fed rats. A diet associated decrease of synaptophysin, synapsin I, and synaptotagmin I, was found in fructose-fed young and adult rats. Interestingly, BDNF amount was significantly lower only in fructose-fed adult rats, while the level of its receptor TrkB decreased in both groups of treated rats. A further marker of brain functioning, Acetylcholinesterase activity, was found increased only in fructose-fed young animals.Conclusion: Overall, our findings suggest that young rats may severely suffer from the deleterious influence of fructose on brain health as the adults and provide experimental data suggesting the need of targeted nutritional strategies to reduce its amount in foods.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Spagnuolo MS,Bergamo P,Crescenzo R,Iannotta L,Treppiccione L,Iossa S,Cigliano L

doi

10.1080/1028415X.2018.1501532

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

309-320

issue

4

eissn

1028-415X

issn

1476-8305

journal_volume

23

pub_type

杂志文章
  • Vitamin B12-responsive neuropathies: A case series.

    abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830515Y.0000000006

    authors: Solomon LR

    更新日期:2016-05-01 00:00:00

  • Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers.

    abstract::The preschool years (i.e. 1-5 years of age) is a time of rapid and dramatic postnatal brain development (i.e. neural plasticity), and of fundamental acquisition of cognitive development (i.e. working memory, attention and inhibitory control). Also, it is a time of transition from a direct maternal mediation/selection ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,评审

    doi:10.1179/147683009X423454

    authors: Rosales FJ,Reznick JS,Zeisel SH

    更新日期:2009-10-01 00:00:00

  • Caffeine and energy drink use by combat arms soldiers in Afghanistan as a countermeasure for sleep loss and high operational demands.

    abstract:OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1443996

    authors: McLellan TM,Riviere LA,Williams KW,McGurk D,Lieberman HR

    更新日期:2019-11-01 00:00:00

  • Autism and Schizophrenia: Intestinal Disorders.

    abstract::We examined Dohan's hypothesis that schizophrenia is associated with the absorption of "exorphins" contained in gluten and casein. In addition, because of the work of Reichelt et al. (Reichelt, K.L., Saelid, G., Lindback, J. and Orbeck, H. (1986) Biological Psychiatry 21:1279-1290) and Rodriguez et al. (Rodriguez, Tra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747303

    authors: Cade R,Privette M,Fregly M,Rowland N,Sun Z,Zele V,Wagemaker H,Edelstein C

    更新日期:2000-01-01 00:00:00

  • Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.

    abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1585506

    authors: Wang W,Li J,Zhang H,Wang X,Zhang X

    更新日期:2021-01-01 00:00:00

  • Ghrelin as a prominent endocrine factor in stress-induced obesity.

    abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1863740

    authors: van Loenen MR,Geenen B,Arnoldussen IAC,Kiliaan AJ

    更新日期:2020-12-29 00:00:00

  • Interactive Effects of Neurochemicals on Ingestive Behavior.

    abstract::Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747313

    authors: Roth JD,Rowland NE

    更新日期:2000-01-01 00:00:00

  • Association of higher carbohydrate intake with depressive mood in elderly diabetic women.

    abstract:BACKGROUND:The rates of co-morbid depression with elderly diabetes are reportedly high. Although the intake of several nutrients has been suggested to be associated with depressive symptoms, the chronic effects of carbohydrate intake on mood remain unclear. In the current study, the association of the carbohydrate ener...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,多中心研究

    doi:10.1179/147683009X423463

    authors: Umegaki H,Iimuro S,Araki A,Sakurai T,Iguchi A,Yoshimura Y,Ohashi Y,Ito H

    更新日期:2009-12-01 00:00:00

  • Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).

    abstract::Background/aim: Vitamin D has been hypothesized to be main regulator of the aging rate, alongside evidences support its role in neuroprotection. However, data about the protective role of vitamin D against neurophysiologic alterations associated with brain aging is limited. This study investigated the possible protect...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1665854

    authors: Khairy EY,Attia MM

    更新日期:2019-09-16 00:00:00

  • Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene expression in chicks.

    abstract:OBJECTIVE:The objective of this study was to determine the influence of dietary macronutrient composition on central NPY's orexigenic effect in chicks. METHODS:Day-of-hatch chicks were fed one of three diets (3000 kcal ME/kg) ad libitum from hatch: high carbohydrate (HC), high fat (HF; 30% ME derived from soybean oil)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2017.1296606

    authors: McConn BR,Cline MA,Gilbert ER

    更新日期:2018-07-01 00:00:00

  • Iodine Deficiency and the Brain.

    abstract::The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747292

    authors: Hetzel BS

    更新日期:1999-01-01 00:00:00

  • Malnutrition and REM-sleep deprivation modulate in rats the impairment of spreading depression by a single sub-convulsing dose of pilocarpine.

    abstract::This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150412331281031

    authors: De Vasconcelos CA,De Oliveira JA,De Oliveira Costat LA,Guedes RC

    更新日期:2004-06-01 00:00:00

  • Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense.

    abstract::Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1815330

    authors: Dos Santos E,Radai JAS,do Nascimento KF,Formagio ASN,de Matos Balsalobre N,Ziff EB,Castelon Konkiewitz E,Kassuya CAL

    更新日期:2020-09-11 00:00:00

  • The effects of dietary sulfur amino acid deficiency on rat brain glutathione concentration and neural damage in global hemispheric hypoxia-ischemia.

    abstract::Primary brain injury in stroke is followed by an excitotoxic cascade, oxidative stress and further neural damage. Glutathione is critical and depleted in oxidative stress. Since cysteine is limiting in glutathione synthesis, this study investigated the effect of dietary sulfur amino acid (SAA) deficiency on neural dam...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415021000055952

    authors: Bobyn PJ,Franklin JL,Wall CM,Thornhill JA,Juurlink BH,Paterson PG

    更新日期:2002-12-01 00:00:00

  • Infant iron deficiency, iron supplementation, and psychosocial stress as predictors of neurocognitive development in Chilean adolescents.

    abstract::Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1651105

    authors: Doom JR,Gahagan S,Caballero G,Encina P,Lozoff B

    更新日期:2019-08-09 00:00:00

  • Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids.

    abstract:PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1180859

    authors: Abdel-Maksoud SM,Hassanein SI,Gohar NA,Attia SMM,Gad MZ

    更新日期:2017-10-01 00:00:00

  • Response to Energy Dilution in the Short Term: Evidence of Nutritional Wisdom in Young Children?

    abstract::Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747329

    authors: Hetherington MM,Wood C,Lyburn SC

    更新日期:2000-01-01 00:00:00

  • Is the maturation of monosynaptic stretch reflex in rats affected by neonatal malnutrition?

    abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X344138

    authors: Freitas-Silva SR,Manhães-de-Castro R,Pérot C

    更新日期:2008-10-01 00:00:00

  • Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells.

    abstract:OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830512Y.0000000020

    authors: Chen JC,Liu KS,Yang TJ,Hwang JH,Chan YC,Lee IT

    更新日期:2012-11-01 00:00:00

  • Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra.

    abstract:PURPOSE:The Mediterranean diet has been postulated as a protective factor against different diseases including stroke. Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovas...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150290007047

    authors: Martínez-González MA,Sanchez-Villegas A,De Irala J,Marti A,Martínez JA

    更新日期:2002-02-01 00:00:00

  • Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

    abstract::Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415031000111273

    authors: O'Shea M,Hansen MJ,Tatemoto K,Morris MJ

    更新日期:2003-06-01 00:00:00

  • The effect of breakfast versus no breakfast on brain activity in adolescents when performing cognitive tasks, as assessed by fMRI.

    abstract:OBJECTIVES:The study examined the feasibility of utilizing functional magnetic resonance imaging (fMRI) with a group of adolescent boys and girls to assess modifications in cognitive function, dependent upon the nutritional state of the participants. METHODS:Twenty children aged 12-14 years completed two cognitive tri...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000011

    authors: Fulford J,Varley-Campbell JL,Williams CA

    更新日期:2016-01-01 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1468535

    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Sulfur amino acid deficiency depresses brain glutathione concentration.

    abstract::Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415x.2001.11747364

    authors: Paterson PG,Lyon AW,Kamencic H,Andersen LB,Juurlink BH

    更新日期:2001-01-01 00:00:00

  • Low dietary protein is associated with an increase in food intake and a decrease in the in vitro release of radiolabeled glutamate and GABA from the lateral hypothalamus.

    abstract::Moderately low-protein diets lead to a rapid increase in food intake and body fat. The increase in feeding is associated with a decrease in the concentration of serum urea nitrogen, suggesting that the low-protein-induced increase in food intake may be related to the decreased metabolism of nitrogen from amino acids. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150310001640365

    authors: White BD,Du F,Higginbotham DA

    更新日期:2003-12-01 00:00:00

  • A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.

    abstract::We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/110284150600955164

    authors: Iwasaki Y,Morita A,Iwasawa T,Kobata K,Sekiwa Y,Morimitsu Y,Kubota K,Watanabe T

    更新日期:2006-06-01 00:00:00

  • Protective role of curcumin against sulfite-induced structural changes in rats' medial prefrontal cortex.

    abstract:OBJECTIVES:Sodium metabisulfite as a food preservative can affect the central nervous system. Curcumin, the main ingredient of turmeric has neuroprotective activity. This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods. METHODS:Thirt...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000123

    authors: Noorafshan A,Asadi-Golshan R,Abdollahifar MA,Karbalay-Doust S

    更新日期:2015-08-01 00:00:00

  • A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.

    abstract::A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...

    journal_title:Nutritional neuroscience

    pub_type: 信件

    doi:10.1080/1028415X.2020.1728473

    authors: Cortés-Álvarez NY,Vuelvas-Olmos CR,Pinto-González MF,Guzmán-Muñiz J,Gonzalez-Perez O,Moy-López NA

    更新日期:2020-02-19 00:00:00

  • Lasting metabolic effect of a high-fructose diet on global cerebral ischemia.

    abstract::Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1841482

    authors: Patience Ojo O,Perez-Corredor PA,Gutierrez-Vargas JA,Busayo Akinola O,Cardona-Gómez GP

    更新日期:2020-11-08 00:00:00

  • Lactobacillus helveticus-fermented milk improves learning and memory in mice.

    abstract:OBJECTIVES:To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. METHODS:We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learni...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000122

    authors: Ohsawa K,Uchida N,Ohki K,Nakamura Y,Yokogoshi H

    更新日期:2015-07-01 00:00:00