Lactobacillus helveticus-fermented milk improves learning and memory in mice.

Abstract:

OBJECTIVES:To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. METHODS:We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learning and working memory in mice using the novel object recognition test, which does not involve primary reinforcement (food or electric shocks). A total of 195 male ddY mice were used in the spontaneous alternation behaviour test and 60 in the novel object recognition test. RESULTS:Forced orally administered Calpis sour milk whey powder (200 and 2000 mg/kg) significantly improved scopolamine-induced cognitive impairments (P < 0.05 and P < 0.01, respectively) and object recognition memory (2000 mg/kg; P < 0.05). DISCUSSION:These results suggest that Calpis sour milk whey may be useful for the prevention of neurodegenerative disorders, such as Alzheimer's disease, and enhancing learning and memory in healthy human subjects; however, human clinical studies are necessary.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Ohsawa K,Uchida N,Ohki K,Nakamura Y,Yokogoshi H

doi

10.1179/1476830514Y.0000000122

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

232-40

issue

5

eissn

1028-415X

issn

1476-8305

journal_volume

18

pub_type

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