A novel insight on chronic AlCl3 neurotoxicity through IL-6 and GFAP expressions: modulating effect of functional food fenugreek seeds.

Abstract:

OBJECTIVE:This study was designed to review the effect of chronic aluminium exposure on interleukin-6 (IL-6) secretion in the posterior brain and test the putative modulating effect of fenugreek seeds. METHODS:Female Wistar rats were divided into four groups: control; AlCl3 during 5 months (500 mg/kg body weight, intragastric for 1 month then 1600 ppm via the drinking water); AlCl3 plus fenugreek seed powder (FSP) (5%) during the last 2 months and FSP alone. RESULTS:Oral administration of aluminium chloride during 5 months caused hypoproduction of IL-6 together with a decrease in GFAP reactivity and an alteration of antioxidant status in the posterior brain. On the other hand, fenugreek seeds supplementation was able to enhance IL-6 expression, re-increase GFAP reactivity, and modulate the pro-oxidant-related effect. DISCUSSION:In the context of recent researches, IL-6 hypoproduction in the posterior brain could be a novel mechanism of Al chronic toxicity with a direct effect on glial cells. Using FSP as a diet supplement could offer a neuroprotective effect against Al toxicity. This could be mediated by astroglial cells protection, antioxidant and immunomodulatory actions.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Belaïd-Nouira Y,Bakhta H,Samoud S,Trimech M,Haouas Z,Ben Cheikh H

doi

10.1179/1476830512Y.0000000048

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

218-24

issue

5

eissn

1028-415X

issn

1476-8305

journal_volume

16

pub_type

杂志文章
  • Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.

    abstract::Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830510Y.0000000001

    authors: Pifferi F,Tremblay S,Croteau E,Fortier M,Tremblay-Mercier J,Lecomte R,Cunnane SC

    更新日期:2011-03-01 00:00:00

  • Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population.

    abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1871212

    authors: Zhou Y,Chen J,Gong X,Lu Z,Hua H,Zhu X,Shi P,Li X,Zhou S,Wang Y,Qian T

    更新日期:2021-01-23 00:00:00

  • The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis.

    abstract:OBJECTIVES:To explore the association between dietary factors including fat, fruit and vegetable intake, dairy and meat consumption, and health-related quality of life (HRQOL), disability and relapse rate in a large international sample of people with multiple sclerosis (MS). METHODS:Participants with MS were recruite...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000117

    authors: Hadgkiss EJ,Jelinek GA,Weiland TJ,Pereira NG,Marck CH,van der Meer DM

    更新日期:2015-04-01 00:00:00

  • Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

    abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747241

    authors: Vadnal R

    更新日期:1998-01-01 00:00:00

  • Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects.

    abstract::Organophosphorus compounds are widely used in agriculture. Epidemiological studies propose that pesticide exposure is a risk factor for Alzheimer's disease (AD), but the mechanisms are unclear. Here, we investigated the impact of malathion exposure on the cognitive ability and the underlying mechanisms in rats. Moreov...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1492772

    authors: Mohammadzadeh L,Abnous K,Razavi BM,Hosseinzadeh H

    更新日期:2020-03-01 00:00:00

  • Vitamin B12-responsive neuropathies: A case series.

    abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830515Y.0000000006

    authors: Solomon LR

    更新日期:2016-05-01 00:00:00

  • A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.

    abstract::A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...

    journal_title:Nutritional neuroscience

    pub_type: 信件

    doi:10.1080/1028415X.2020.1728473

    authors: Cortés-Álvarez NY,Vuelvas-Olmos CR,Pinto-González MF,Guzmán-Muñiz J,Gonzalez-Perez O,Moy-López NA

    更新日期:2020-02-19 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1468535

    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Early postnatal protein malnutrition causes resistance to the anxiolytic effects of diazepam as assessed by the fear-potentiated startle test.

    abstract::Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150601168346

    authors: Françolin-Silva AL,Brandão ML,Almeida SS

    更新日期:2007-02-01 00:00:00

  • Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress.

    abstract::To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683010X12611460763481

    authors: Kurauchi I,Shigemi K,Kabuki Y,Hamasu K,Yamane H,Aoki M,Kawada Y,Morishita K,Denbow DM,Furuse M

    更新日期:2010-02-01 00:00:00

  • Early undernutrition decreases the number of neurons in the locus coeruleus of rats.

    abstract::The effects of perinatal undernutrition on the number of neurons and apoptotic cells of the locus coeruleus (LC) of female and male rats at postpartum days 7, 12, 20, 30 and 60 were studied. Undernutrition reduces the number of neurons in both sexes without affecting cell death, as indicated by the ratio of apoptotic ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150600937873

    authors: Pinos H,Collado P,Salas M,Pérez-Torrero E

    更新日期:2006-10-01 00:00:00

  • Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.

    abstract::Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150701587338

    authors: Tomonaga S,Hayakawa T,Yamane H,Maemura H,Sato M,Takahata Y,Morimatsu F,Furuse M

    更新日期:2007-06-01 00:00:00

  • A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.

    abstract::We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/110284150600955164

    authors: Iwasaki Y,Morita A,Iwasawa T,Kobata K,Sekiwa Y,Morimitsu Y,Kubota K,Watanabe T

    更新日期:2006-06-01 00:00:00

  • Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide.

    abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1819104

    authors: Spohr L,Luduvico KP,Soares MSP,Bona NP,Oliveira PS,de Mello JE,Alvez FL,Teixeira FC,Felix AOC,Stefanello FM,Spanevello RM

    更新日期:2020-09-21 00:00:00

  • Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments.

    abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683008X301388

    authors: Marton E,Feletti A,Mazzucco GM,Longatti P

    更新日期:2008-02-01 00:00:00

  • Lesions of the lateral parabrachial area block the aversive component and induced-flavor preference for the delayed intragastric administration of nutrients in rats: effects on subsequent food and water intake.

    abstract::The aim of this study was to examine the function of the lateral parabrachial area (LPB) in relation to the intragastric administration of nutrients. The consumption of flavors associated with intragastric nutrient administration and the subsequent food and water intake were measured in rats with lesions in the LPB. T...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150600576655

    authors: Zafra MA,Simón MJ,Molina F,Puerto A

    更新日期:2005-10-01 00:00:00

  • The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers.

    abstract:OBJECTIVE:The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS:The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical work...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000023

    authors: Mohammadi AA,Jazayeri S,Khosravi-Darani K,Solati Z,Mohammadpour N,Asemi Z,Adab Z,Djalali M,Tehrani-Doost M,Hosseini M,Eghtesadi S

    更新日期:2016-11-01 00:00:00

  • Sulfur amino acid deficiency depresses brain glutathione concentration.

    abstract::Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415x.2001.11747364

    authors: Paterson PG,Lyon AW,Kamencic H,Andersen LB,Juurlink BH

    更新日期:2001-01-01 00:00:00

  • Malnutrition and REM-sleep deprivation modulate in rats the impairment of spreading depression by a single sub-convulsing dose of pilocarpine.

    abstract::This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150412331281031

    authors: De Vasconcelos CA,De Oliveira JA,De Oliveira Costat LA,Guedes RC

    更新日期:2004-06-01 00:00:00

  • Brain activity and connectivity changes in response to nutritive natural sugars, non-nutritive natural sugar replacements and artificial sweeteners.

    abstract::Introduction: The brain plays an important regulatory role in directing energy homeostasis and eating behavior. The increased ingestion of sugars and sweeteners over the last decades makes investigating the effects of these substances on the regulatory function of the brain of particular interest. We investigated whol...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1639306

    authors: Van Opstal AM,Hafkemeijer A,van den Berg-Huysmans AA,Hoeksma M,Mulder TPJ,Pijl H,Rombouts SARB,van der Grond J

    更新日期:2019-07-10 00:00:00

  • Association between poor nutritional status and severe depression in Korean cerebral infarction patients.

    abstract:OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830511Y.0000000023

    authors: Lim HJ,Choue R

    更新日期:2012-01-01 00:00:00

  • Changes of growth hormone-releasing hormone and somatostatin neurons in the rat hypothalamus induced by genistein: a stereological study.

    abstract:OBJECTIVES:Genistein is a plant-derived estrogenic isoflavone commonly found in dietary and therapeutic supplements, due to its potential health benefits. Growth hormone-releasing hormone (GHRH) and somatostatin (SS) are neurosecretory peptides synthesized in neurons of the hypothalamus and regulate the growth hormone ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000143

    authors: Trifunović S,Manojlović-Stojanoski M,Ristić N,Nestorović N,Medigović I,Živanović J,Milošević V

    更新日期:2016-12-01 00:00:00

  • Ghrelin as a prominent endocrine factor in stress-induced obesity.

    abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1863740

    authors: van Loenen MR,Geenen B,Arnoldussen IAC,Kiliaan AJ

    更新日期:2020-12-29 00:00:00

  • Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.

    abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1585506

    authors: Wang W,Li J,Zhang H,Wang X,Zhang X

    更新日期:2021-01-01 00:00:00

  • Differential Effects of Prenatal Protein Malnutrition and Prenatal Cocaine on Radial Arm Maze Performance in Adult Male Rats.

    abstract::The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747269

    authors: Shumsky JS,Shultz PL,Galler JR,Tonkiss J

    更新日期:1999-01-01 00:00:00

  • The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.

    abstract::The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683009X388850

    authors: Márquez-Valadez B,Lugo-Huitrón R,Valdivia-Cerda V,Miranda-Ramírez LR,Pérez-De La Cruz V,González-Cuahutencos O,Rivero-Cruz I,Mata R,Santamaría A,Pedraza-Chaverrí J

    更新日期:2009-02-01 00:00:00

  • Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States.

    abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1794422

    authors: Bigman G

    更新日期:2020-07-20 00:00:00

  • Infant iron deficiency, iron supplementation, and psychosocial stress as predictors of neurocognitive development in Chilean adolescents.

    abstract::Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1651105

    authors: Doom JR,Gahagan S,Caballero G,Encina P,Lozoff B

    更新日期:2019-08-09 00:00:00

  • Moderate Alcohol Intake: Behavioral and Neurochemical Correlates in Rats.

    abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747224

    authors: Battaini F,Pascale A,Ancona DM,Cagiano R,Cuomo V,Govoni S

    更新日期:1998-01-01 00:00:00