Abstract:
OBJECTIVE:This study was designed to review the effect of chronic aluminium exposure on interleukin-6 (IL-6) secretion in the posterior brain and test the putative modulating effect of fenugreek seeds. METHODS:Female Wistar rats were divided into four groups: control; AlCl3 during 5 months (500 mg/kg body weight, intragastric for 1 month then 1600 ppm via the drinking water); AlCl3 plus fenugreek seed powder (FSP) (5%) during the last 2 months and FSP alone. RESULTS:Oral administration of aluminium chloride during 5 months caused hypoproduction of IL-6 together with a decrease in GFAP reactivity and an alteration of antioxidant status in the posterior brain. On the other hand, fenugreek seeds supplementation was able to enhance IL-6 expression, re-increase GFAP reactivity, and modulate the pro-oxidant-related effect. DISCUSSION:In the context of recent researches, IL-6 hypoproduction in the posterior brain could be a novel mechanism of Al chronic toxicity with a direct effect on glial cells. Using FSP as a diet supplement could offer a neuroprotective effect against Al toxicity. This could be mediated by astroglial cells protection, antioxidant and immunomodulatory actions.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Belaïd-Nouira Y,Bakhta H,Samoud S,Trimech M,Haouas Z,Ben Cheikh Hdoi
10.1179/1476830512Y.0000000048subject
Has Abstractpub_date
2013-09-01 00:00:00pages
218-24issue
5eissn
1028-415Xissn
1476-8305journal_volume
16pub_type
杂志文章abstract::Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830510Y.0000000001
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1871212
更新日期:2021-01-23 00:00:00
abstract:OBJECTIVES:To explore the association between dietary factors including fat, fruit and vegetable intake, dairy and meat consumption, and health-related quality of life (HRQOL), disability and relapse rate in a large international sample of people with multiple sclerosis (MS). METHODS:Participants with MS were recruite...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000117
更新日期:2015-04-01 00:00:00
abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747241
更新日期:1998-01-01 00:00:00
abstract::Organophosphorus compounds are widely used in agriculture. Epidemiological studies propose that pesticide exposure is a risk factor for Alzheimer's disease (AD), but the mechanisms are unclear. Here, we investigated the impact of malathion exposure on the cognitive ability and the underlying mechanisms in rats. Moreov...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1492772
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000006
更新日期:2016-05-01 00:00:00
abstract::A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...
journal_title:Nutritional neuroscience
pub_type: 信件
doi:10.1080/1028415X.2020.1728473
更新日期:2020-02-19 00:00:00
abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1809875
更新日期:2020-10-09 00:00:00
abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1468535
更新日期:2020-01-01 00:00:00
abstract::Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wist...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150601168346
更新日期:2007-02-01 00:00:00
abstract::To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683010X12611460763481
更新日期:2010-02-01 00:00:00
abstract::The effects of perinatal undernutrition on the number of neurons and apoptotic cells of the locus coeruleus (LC) of female and male rats at postpartum days 7, 12, 20, 30 and 60 were studied. Undernutrition reduces the number of neurons in both sexes without affecting cell death, as indicated by the ratio of apoptotic ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150600937873
更新日期:2006-10-01 00:00:00
abstract::Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150701587338
更新日期:2007-06-01 00:00:00
abstract::We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor po...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/110284150600955164
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819104
更新日期:2020-09-21 00:00:00
abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683008X301388
更新日期:2008-02-01 00:00:00
abstract::The aim of this study was to examine the function of the lateral parabrachial area (LPB) in relation to the intragastric administration of nutrients. The consumption of flavors associated with intragastric nutrient administration and the subsequent food and water intake were measured in rats with lesions in the LPB. T...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150600576655
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS:The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical work...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1179/1476830515Y.0000000023
更新日期:2016-11-01 00:00:00
abstract::Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415x.2001.11747364
更新日期:2001-01-01 00:00:00
abstract::This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150412331281031
更新日期:2004-06-01 00:00:00
abstract::Introduction: The brain plays an important regulatory role in directing energy homeostasis and eating behavior. The increased ingestion of sugars and sweeteners over the last decades makes investigating the effects of these substances on the regulatory function of the brain of particular interest. We investigated whol...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1639306
更新日期:2019-07-10 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830511Y.0000000023
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Genistein is a plant-derived estrogenic isoflavone commonly found in dietary and therapeutic supplements, due to its potential health benefits. Growth hormone-releasing hormone (GHRH) and somatostatin (SS) are neurosecretory peptides synthesized in neurons of the hypothalamus and regulate the growth hormone ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000143
更新日期:2016-12-01 00:00:00
abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1863740
更新日期:2020-12-29 00:00:00
abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1585506
更新日期:2021-01-01 00:00:00
abstract::The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1999.11747269
更新日期:1999-01-01 00:00:00
abstract::The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X388850
更新日期:2009-02-01 00:00:00
abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1794422
更新日期:2020-07-20 00:00:00
abstract::Objective: The aim of the current study was to examine the unique and joint contributions of iron deficiency, iron supplementation, and psychosocial stress in infancy and stress in adolescence to neurocognitive functioning in adolescence. Methods: The current study (N = 796; Mage = 14.4y) involved a prospective cohort...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1651105
更新日期:2019-08-09 00:00:00
abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747224
更新日期:1998-01-01 00:00:00