Lasting metabolic effect of a high-fructose diet on global cerebral ischemia.

Abstract:

:Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects of a 20% high fructose diet (HFD) and global cerebral ischemia on neurological, cognitive and emotional performance in three-month-old male Wistar rats. Results: Our results demonstrated that fructose intake led to increases in body weight and blood glucose, as well as reduced insulin sensitivity. The co-morbidity of fructose intake and cerebral ischemia resulted to hyperlipidemia, as well as increases in liver and adipocyte damage, which worsened neurological performance and resulted in alterations in learning and emotional skills at two weeks post-ischemia. No significant biochemical changes in autophagy and plasticity markers at the late stage of ischemia were observed. Conclusion: These results suggested that obesity causes a lasting effect on metabolic disorders that can contribute to increased neurological impairment after cerebral ischemia.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Patience Ojo O,Perez-Corredor PA,Gutierrez-Vargas JA,Busayo Akinola O,Cardona-Gómez GP

doi

10.1080/1028415X.2020.1841482

subject

Has Abstract

pub_date

2020-11-08 00:00:00

pages

1-14

eissn

1028-415X

issn

1476-8305

pub_type

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