Abstract:
:The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Vavassori S,Wang K,Schweizer LM,Schweizer Mdoi
10.1042/BST20051154keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1154-7issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST20051154journal_volume
33pub_type
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