Assay of methylglyoxal-derived protein and nucleotide AGEs.

abstract：:Bioprocess monitoring is used to track the progress of a cell culture and ensure that the product quality is maintained. Current schemes for monitoring metabolism rely on offline measurements of samples of the extracellular medium. However, in the era of synthetic biology, it is now possible to design and implement bi...

journal_title：Biochemical Society transactions

authors： Constantinou A,Polizzi KM

更新日期：2013-10-01 00:00:00

abstract：:The statins are inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (HMG-CoAR), and are utilized to decrease levels of atherogenic lipoproteins in patients with, or who are at high risk of, cardiovascular disease. This study describes the inhibition of a recombinant, catalytic fragment of human HMG-CoAR b...

journal_title：Biochemical Society transactions

authors： Holdgate GA,Ward WH,McTaggart F

更新日期：2003-06-01 00:00:00

abstract：:Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokine...

journal_title：Biochemical Society transactions

authors： Kirschner K,Rattanavirotkul N,Quince MF,Chandra T

更新日期：2020-06-30 00:00:00

abstract：:Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translatio...

journal_title：Biochemical Society transactions

authors： Ray S,Catnaigh PÓ,Anderson EC

更新日期：2015-06-01 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear intermediate filaments the A-type lamins, result in a wide variety of diseases known as laminopathies. Some of them, such as familial partial lipodystrophy of Dunnigan and metabolic laminopathies, are characterized by lipodystrophic syndromes with altered fat distributi...

journal_title：Biochemical Society transactions

authors： Bidault G,Vatier C,Capeau J,Vigouroux C,Béréziat V

更新日期：2011-12-01 00:00:00

abstract：:Delineating the molecular pathways underlying seizure-induced neuronal death may yield novel strategies for brain protection against prolonged or repetitive seizures. Glutamate-mediated excitotoxicity and necrosis is a primary contributing mechanism but seizures also activate programmed (apoptotic) cell death pathways...

journal_title：Biochemical Society transactions

authors： Henshall DC

更新日期：2007-04-01 00:00:00

abstract：:The yeast Sir2 (silent information regulator-2) protein functions as an NAD(+)-dependent histone deacetylase to silence gene expression from the mating-type locus, tolomeres and rDNA and also promotes longevity and genome stability in response to calorie restriction. Homologues of yeast Sir2 have been identified in th...

journal_title：Biochemical Society transactions

authors： Marmorstein R

更新日期：2004-12-01 00:00:00

abstract：:Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected DNA damage may impede cellular propagation or even result in cell death, making it critical to restore genomic integrity. Decades of research have revealed a wide range of mechanisms thro...

journal_title：Biochemical Society transactions

authors： Ghodke H,Ho H,van Oijen AM

更新日期：2018-02-19 00:00:00

abstract：:The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. T...

journal_title：Biochemical Society transactions

authors： Patel MS,Korotchkina LG

更新日期：2006-04-01 00:00:00

abstract：:The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

journal_title：Biochemical Society transactions

authors： Dalgleish R

更新日期：1988-10-01 00:00:00

abstract：:Colicins are proteins produced by some strains of Escherichia coli to kill competitors belonging to the same species. Among them, ColM (colicin M) is the only one that blocks the biosynthesis of peptidoglycan, a specific bacterial cell-wall polymer essential for cell integrity. ColM acts in the periplasm by hydrolysin...

journal_title：Biochemical Society transactions

authors： Touzé T,Barreteau H,El Ghachi M,Bouhss A,Barnéoud-Arnoulet A,Patin D,Sacco E,Blanot D,Arthur M,Duché D,Lloubès R,Mengin-Lecreulx D

更新日期：2012-12-01 00:00:00

abstract：:The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Ther...

journal_title：Biochemical Society transactions

authors： Johnson WE,Roberts S

更新日期：2007-08-01 00:00:00

abstract：:Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

journal_title：Biochemical Society transactions

authors： Falasca M,Maffucci T

更新日期：2007-04-01 00:00:00

abstract：:There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2 expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE(2) acts through four E-prostanoid receptors (EP1-4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal canc...

journal_title：Biochemical Society transactions

authors： Chell S,Patsos HA,Qualtrough D,H-Zadeh AM,Hicks DJ,Kaidi A,Witherden IR,Williams AC,Paraskeva C

更新日期：2005-08-01 00:00:00

abstract：:The neurotrophins nerve growth factor, brain-derived neurotrophic factor, NT-3 (neurotrophin 3) and NT-4 are known for regulating neuron development, function and survival. Beyond this, neurotrophins were found to exert multiple effects on non-neuronal cells such as immune cells, smooth muscle and epithelial cells. In...

journal_title：Biochemical Society transactions

authors： Rochlitzer S,Nassenstein C,Braun A

更新日期：2006-08-01 00:00:00

abstract：:Mitochondrial disorders are a group of genetic diseases affecting the energy-converting process of oxidative phosphorylation. The extreme variability of symptoms, organ involvement, and clinical course represent a challenge to the development of effective therapeutic interventions. However, new possibilities have rece...

journal_title：Biochemical Society transactions

authors： Viscomi C

更新日期：2016-10-15 00:00:00

abstract：:We have been analysing the signalling systems that couple to receptors of the TIR (Toll/interleukin-1 receptor) family, which signal through a common cytoplasm region; the TIR domain. These systems are of both practical and fundamental biological significance, being central to the pathogenesis of chronic inflammatory ...

journal_title：Biochemical Society transactions

authors： Dower SK,Qwarnstrom EE

更新日期：2003-12-01 00:00:00

abstract：:This article reviews the progress of a personal endeavour to develop chromatography as a quantitative procedure for the determination of reaction stoichiometries and equilibrium constants governing protein interactions. As well as affording insight into an aspect of chromatography with which many protein chemists are ...

journal_title：Biochemical Society transactions

authors： Winzor DJ

更新日期：2003-10-01 00:00:00

abstract：:The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinit...

journal_title：Biochemical Society transactions

authors： Mayans O,Benian GM,Simkovic F,Rigden DJ

更新日期：2013-08-01 00:00:00

abstract：:Multiple cellular proteins have been identified as participating in Toll/interleukin-1 receptor-mediated inflammatory gene expression. The continuing isolation of novel components, based on sequence similarities, protein-protein interactions and protein purification, suggests that many elements of this signalling netw...

journal_title：Biochemical Society transactions

authors： Kiss-Toth E,Wyllie DH,Holland K,Marsden L,Jozsa V,Oxley KM,Polgar T,Qwarnstrom EE,Dower SK

更新日期：2005-12-01 00:00:00

abstract：:Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-positive breast cancer patients, and is considered as a keystone of systemic cancer therapy. Likewise, HER2-targeted therapy significantly improved the survival of HER2-positive breast cancer patients, indicating that targeted therap...

journal_title：Biochemical Society transactions

authors： Lev S

更新日期：2020-04-29 00:00:00

abstract：:Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus entraps microbes and particles removing them from the lungs via the co-ordinated beating of motile cilia. This mechanism of lung defen...

journal_title：Biochemical Society transactions

authors： Ridley C,Thornton DJ

更新日期：2018-10-19 00:00:00

abstract：:Photosynthesis is fundamental to biomass production, but is a dynamic process sensitive to environmental constraints. In recent years, approaches to increase biomass and grain yield by altering photosynthetically related processes in the plant have received considerable attention. However, improving biomass yield requ...

journal_title：Biochemical Society transactions

authors： Heyneke E,Fernie AR

更新日期：2018-04-17 00:00:00

abstract：:Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to sig...

journal_title：Biochemical Society transactions

authors： Verslues PE,Zhu JK

更新日期：2005-04-01 00:00:00

abstract：:Protein-protein interactions are a regulatory mechanism for a number of physiological and pathological cellular processes. Neurodegenerative diseases, such as AD (Alzheimer's disease), are associated with the accelerated production or delayed clearance of protein aggregates. Hence, inhibition of pathologic protein-pro...

journal_title：Biochemical Society transactions

authors： Bose M,Gestwicki JE,Devasthali V,Crabtree GR,Graef IA

更新日期：2005-08-01 00:00:00

abstract：:Although the Gompertz formula accurately describes observed mortality distributions over most of their extent, their 'tail' is much longer than that of a Gompertz curve fitted to the whole data set. A simple candidate explanation is that the longest-lived subset of any population will necessarily be enriched in indivi...

journal_title：Biochemical Society transactions

authors： de Grey AD

更新日期：2003-04-01 00:00:00

abstract：:Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

journal_title：Biochemical Society transactions

authors： Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

更新日期：2017-04-15 00:00:00

abstract：:Understanding how cognitive processes including learning, memory, decision making and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. Schizophrenia is a common disease with cognitive symptoms, high heri...

journal_title：Biochemical Society transactions

authors： Tam GW,van de Lagemaat LN,Redon R,Strathdee KE,Croning MD,Malloy MP,Muir WJ,Pickard BS,Deary IJ,Blackwood DH,Carter NP,Grant SG

更新日期：2010-04-01 00:00:00

abstract：:Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction s...

journal_title：Biochemical Society transactions

authors： Campbell ID

更新日期：2008-04-01 00:00:00

abstract：:The EMLs are a conserved family of microtubule-associated proteins (MAPs). The founding member was discovered in sea urchins as a 77-kDa polypeptide that co-purified with microtubules. This protein, termed EMAP for echinoderm MAP, was the major non-tubulin component present in purified microtubule preparations made fr...

journal_title：Biochemical Society transactions

authors： Fry AM,O'Regan L,Montgomery J,Adib R,Bayliss R

更新日期：2016-10-15 00:00:00