Tuning T helper cell differentiation by ITK.

Abstract:

:CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.

journal_name

Biochem Soc Trans

authors

Elmore JP,McGee MC,Nidetz NF,Anannya O,Huang W,August A

doi

10.1042/BST20190486

subject

Has Abstract

pub_date

2020-02-28 00:00:00

pages

179-185

issue

1

eissn

0300-5127

issn

1470-8752

pii

222095

journal_volume

48

pub_type

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