Abstract:
:To maintain genomic stability, despite constant exposure to agents that damage DNA, eukaryotic cells have developed elaborate and highly conserved pathways of DNA damage sensing, signalling and repair. In this review, we concentrate mainly on what we know about DNA damage sensing with particular reference to Lcd1p, a yeast protein that functions early in DNA damage signalling, and MDC1 (mediator of DNA damage checkpoint 1), a recently identified human protein that may be involved in recruiting the MRE11 complex to radiation-induced nuclear foci. We describe a model for the DNA damage response in which factors are recruited sequentially to sites of DNA damage to form complexes that can amplify the original signal and propagate it to the multitude of response pathways necessary for genome stability.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Bradbury JM,Jackson SPdoi
10.1042/bst0310040keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
40-4issue
Pt 1eissn
0300-5127issn
1470-8752journal_volume
31pub_type
杂志文章,评审abstract::We have described a large number of different mutations in the LPL gene that result in completely catalytically defective LPL protein. More recently exonic polymorphisms in the LPL gene have been described that do not result in the catalytic activity of LPL being significantly impaired. Furthermore we have recently de...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0210506
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0340435
更新日期:2006-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2020-06-29 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0191112
更新日期:1991-11-01 00:00:00
abstract::Nicotinic ACh (acetylcholine) and 5-HT3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate that the channel lining domain of such receptors is formed by the alpha-helical M2 domain (second transmembrane...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0210039
更新日期:1993-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0340754
更新日期:2006-11-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20120226
更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0320976
更新日期:2004-12-01 00:00:00
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journal_title:Biochemical Society transactions
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abstract::Glyoxalase I is part of the glyoxalase system present in the cytosol of cells. The glyoxalase system catalyses the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids. Glyoxalase I catalyses the isomerization of the hemithioacetal, formed spontaneously from alpha-oxoaldehyde an...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0311343
更新日期:2003-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20120073
更新日期:2012-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0391441
更新日期:2011-10-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2011-04-01 00:00:00
abstract::AS (alternative splicing) is a post-transcriptional process which regulates gene expression through increasing protein complexity and modulating mRNA transcript levels. Regulation of AS depends on interactions between trans-acting protein factors and cis-acting signals in the pre-mRNA (precursor mRNA) transcripts, ter...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2012-02-01 00:00:00
abstract::Stimulus-response coupling in animal cells frequently involves the hydrolysis of PtdIns(4,5)P(2) which is catalysed by phosphoinositide-specific phospholipase C (PI-PLC). There is an increasing body of evidence for PI-PLC-based signalling in plant cells; however, the physiological role of this system remains poorly do...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-dis...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2018-12-17 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2008-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2020-08-28 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
abstract::SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00