Biological consequences of statins in Candida species and possible implications for human health.

abstract：:The action of VEGF (vascular endothelial growth factor) is essential to maintain proper endothelial and vascular function. VEGF stimulates virtually all aspects of endothelial function, namely proliferation, migration, permeability and nitric oxide production and release. In addition, the action of VEGF makes the endo...

journal_title：Biochemical Society transactions

authors： Waltenberger J

更新日期：2009-12-01 00:00:00

abstract：:Formin family proteins (formins) represent an evolutionary conserved protein family encoded in the genome of a wide range of eukaryotes. Formins are hallmarked by a formin homology 1 (FH1) domain juxtaposed to an FH2 domain whereby they control actin and microtubule dynamics. Not surprisingly, formins are best known a...

journal_title：Biochemical Society transactions

authors： Isogai T,Innocenti M

更新日期：2016-12-15 00:00:00

abstract：:Large single crystals (up to 1 mm in each dimension) of the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050 have been grown in the presence of beta-octyl-glucoside. These crystals have the space group R32 and unit cell dimensions of a = b = 119.9 A and c = 297.0 A. Recently we have improved our ...

journal_title：Biochemical Society transactions

authors： Cogdell RJ,Halloren E,Hawthornthwaite AM,Thunnissen MM,Freer AA,McDermott G,Guthrie N,Isaacs N,Lindsay JG,Papiz M

更新日期：1993-02-01 00:00:00

abstract：:We have been analysing the signalling systems that couple to receptors of the TIR (Toll/interleukin-1 receptor) family, which signal through a common cytoplasm region; the TIR domain. These systems are of both practical and fundamental biological significance, being central to the pathogenesis of chronic inflammatory ...

journal_title：Biochemical Society transactions

authors： Dower SK,Qwarnstrom EE

更新日期：2003-12-01 00:00:00

abstract：:Intellectual disability (ID) affects at least 1% of the population, and typically presents in the first few years of life. ID is characterized by impairments in cognition and adaptive behavior and is often accompanied by further delays in language and motor skills, as seen in many neurodevelopmental disorders (NDD). R...

journal_title：Biochemical Society transactions

authors： Weil D,Piton A,Lessel D,Standart N

更新日期：2020-06-30 00:00:00

abstract：:DNA methylation at the fifth position of cytosine is a major epigenetic mark conserved in plants and mammals. Genome-wide DNA methylation patterns are dynamically controlled by integrated activities of establishment, maintenance, and removal. In both plants and mammals, a pattern of global DNA hypomethylation coupled ...

journal_title：Biochemical Society transactions

authors： Zhang H,Zhang K,Zhu JK

更新日期：2019-08-30 00:00:00

abstract：:USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53-mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein-Barr nuclear antigen 1 protein of Epstein-Barr virus binds with high affinity to USP7 and disrupts the USP7-p53 interaction. The...

journal_title：Biochemical Society transactions

authors： Holowaty MN,Frappier L

更新日期：2004-11-01 00:00:00

abstract：:A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...

journal_title：Biochemical Society transactions

authors： Vohra S,Chintapalli SV,Illingworth CJ,Reeves PJ,Mullineaux PM,Clark HS,Dean MK,Upton GJ,Reynolds CA

更新日期：2007-08-01 00:00:00

abstract：:A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immun...

journal_title：Biochemical Society transactions

authors： Holmes C,Butchart J

更新日期：2011-08-01 00:00:00

abstract：:Intracellular cross-talk or synergism between receptors coupled negatively to adenylate cyclase via PTX-sensitive Gi-protein(s) and receptors coupled to phospholipase C via PTX-insensitive G-proteins is prevalent in a variety of cell types (see above) and may represent a universal mechanism for the modulation of phosp...

journal_title：Biochemical Society transactions

authors： Dickenson JM,Hill SJ

更新日期：1993-11-01 00:00:00

abstract：:Glyoxalase- and methylglyoxal-related research has required the development of quantitative and reliable techniques for the measurement of methylglyoxal-derived glycation adducts of protein and DNA. There are also other glycation adducts, oxidation adducts and nitration adducts of proteins and oxidation adducts of DNA...

journal_title：Biochemical Society transactions

authors： Rabbani N,Shaheen F,Anwar A,Masania J,Thornalley PJ

更新日期：2014-04-01 00:00:00

abstract：:Mitochondrial disorders are a group of genetic diseases affecting the energy-converting process of oxidative phosphorylation. The extreme variability of symptoms, organ involvement, and clinical course represent a challenge to the development of effective therapeutic interventions. However, new possibilities have rece...

journal_title：Biochemical Society transactions

authors： Viscomi C

更新日期：2016-10-15 00:00:00

abstract：:Glutamate transporters are essential for terminating synaptic excitation and for maintaining extracellular glutamate concentrations below neurotoxic levels. These transporters also mediate a thermodynamically uncoupled chloride flux that is activated by two of the molecules that they transport - sodium and glutamate. ...

journal_title：Biochemical Society transactions

authors： Kanner BI,Kavanaugh MP,Bendahan A

更新日期：2001-11-01 00:00:00

abstract：:Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has...

journal_title：Biochemical Society transactions

authors： Coppo L,Ghezzi P

更新日期：2011-10-01 00:00:00

abstract：:Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia, such as neovascular eye disease and cancer. Neuropilin 1 (NRP1) is ...

journal_title：Biochemical Society transactions

authors： Lampropoulou A,Ruhrberg C

更新日期：2014-12-01 00:00:00

abstract：:Post-translational modification (PTM) of histones has been investigated in eukaryotes for years, revealing its widespread occurrence and functional importance. Many PTMs affect chromatin folding and gene activity. Only recently the occurrence of such modifications has been recognized in bacteria. However, it is unclea...

journal_title：Biochemical Society transactions

authors： Dilweg IW,Dame RT

更新日期：2018-10-19 00:00:00

abstract：:PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within surviving neurons. Although heritability st...

journal_title：Biochemical Society transactions

authors： Ross OA,Farrer MJ

更新日期：2005-08-01 00:00:00

abstract：:The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth fact...

journal_title：Biochemical Society transactions

authors： Pyne NJ,Waters C,Moughal NA,Sambi BS,Pyne S

更新日期：2003-12-01 00:00:00

abstract：:Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...

journal_title：Biochemical Society transactions

authors： Chivet M,Javalet C,Hemming F,Pernet-Gallay K,Laulagnier K,Fraboulet S,Sadoul R

更新日期：2013-02-01 00:00:00

abstract：:Glucose-stimulated insulin secretion from pancreatic beta-cells requires the kinesin-1/Kif5B-mediated transport of insulin granules along microtubules. 5'-AMPK (5'-AMP-activated protein kinase) is a heterotrimeric serine/threonine kinase which is activated in beta-cells at low glucose concentrations, but inhibited as ...

journal_title：Biochemical Society transactions

authors： McDonald A,Fogarty S,Leclerc I,Hill EV,Hardie DG,Rutter GA

更新日期：2010-02-01 00:00:00

abstract：:A range of mitochondria-targeted probe molecules that comprise a lipophilic cation covalently attached to an active moiety have been developed. The lipophilic cation causes the accumulation of these molecules into mitochondria, driven by the mitochondrial membrane potential. To date, we have targeted antioxidants, spi...

journal_title：Biochemical Society transactions

authors： Murphy MP

更新日期：2004-12-01 00:00:00

abstract：:In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate that cross-talk is context-dependent and that both pathways can activate or inhibi...

journal_title：Biochemical Society transactions

authors： Aksamitiene E,Kiyatkin A,Kholodenko BN

更新日期：2012-02-01 00:00:00

abstract：:PABPs [poly(A)-binding proteins] bind to the poly(A) tail of eukaryotic mRNAs and are conserved in species ranging from yeast to human. The prototypical cytoplasmic member, PABP1, is a multifunctional RNA-binding protein with roles in global and mRNA-specific translation and stability, consistent with a function as a ...

journal_title：Biochemical Society transactions

authors： Smith RW,Blee TK,Gray NK

更新日期：2014-08-01 00:00:00

abstract：:The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. T...

journal_title：Biochemical Society transactions

authors： Patel MS,Korotchkina LG

更新日期：2006-04-01 00:00:00

abstract：:Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there ...

journal_title：Biochemical Society transactions

authors： Agius L,Centelles J,Cascante M

更新日期：2002-04-01 00:00:00

abstract：:The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

journal_title：Biochemical Society transactions

authors： Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

更新日期：2000-12-01 00:00:00

abstract：:Inflammation and dyslipidaemia both play important roles in the development of glomerular atherosclerosis in renal diseases. We have demonstrated that inflammatory mediators induced Scr (scavenger receptor) expression and the formation of foam cells, and that AP-1 (activator protein 1)/ets were necessary transcription...

journal_title：Biochemical Society transactions

authors： Ruan XZ,Moorhead JF,Fernando R,Wheeler DC,Powis SH,Varghese Z

更新日期：2004-02-01 00:00:00

abstract：:Loss of barrier function in the vasculature promotes inflammatory signalling which in turn contributes to the progression of cardiovascular disease. cAMP can protect against endothelial dysfunction through the effectors PKA (protein kinase A) and Epac (exchange protein directly activated by cAMP). The present review o...

journal_title：Biochemical Society transactions

authors： Parnell E,Yarwood SJ

更新日期：2014-04-01 00:00:00

abstract：:A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutation...

journal_title：Biochemical Society transactions

authors： Krishnan KJ,Reeve AK,Turnbull DM

更新日期：2007-11-01 00:00:00

abstract：:Identified five decades ago amongst the most abundant cellular RNAs, small nucleolar RNAs (snoRNAs) were initially described as serving as guides for the methylation and pseudouridylation of ribosomal RNA through direct base pairing. In recent years, however, increasingly powerful high-throughput genomic approaches an...

journal_title：Biochemical Society transactions

authors： Bergeron D,Fafard-Couture É,Scott MS

更新日期：2020-04-29 00:00:00