Innate link between NF-kappaB activity and ubiquitin-like modifiers.

abstract：:In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein-protein interactions of regulatory multiprotein assemblies. Protein-protein interfaces are widely recognized to be challenging targets as...

journal_title：Biochemical Society transactions

authors： Abdel-Rahman N,Martinez-Arias A,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:Alkalithermophiles are an exciting subset of extremophilic organisms and represent extremophiles that are adapted to two extreme conditions, i.e. to a combination of alkaline and thermobiotic growth conditions. Among the anaerobic alkalithermophiles are representatives of both Bacteria and Archaea within a wide variet...

journal_title：Biochemical Society transactions

authors： Wiegel J,Kevbrin VV

更新日期：2004-04-01 00:00:00

abstract：:Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia, such as neovascular eye disease and cancer. Neuropilin 1 (NRP1) is ...

journal_title：Biochemical Society transactions

authors： Lampropoulou A,Ruhrberg C

更新日期：2014-12-01 00:00:00

abstract：:There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

journal_title：Biochemical Society transactions

authors： Wisniewski T,Brown DR,Sigurdsson EM

更新日期：2002-08-01 00:00:00

abstract：:JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death ass...

journal_title：Biochemical Society transactions

authors： Davies C,Tournier C

更新日期：2012-02-01 00:00:00

abstract：:The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular s...

journal_title：Biochemical Society transactions

authors： Weaver LN,Walczak CE

更新日期：2015-02-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters play crucial roles in cellular processes, such as nutrient uptake, drug resistance, cell-volume regulation and others. Despite their importance, all proposed molecular models for transport are based on indirect evidence, i.e. functional interpretation of static crystal structure...

journal_title：Biochemical Society transactions

authors： Husada F,Gouridis G,Vietrov R,Schuurman-Wolters GK,Ploetz E,de Boer M,Poolman B,Cordes T

更新日期：2015-10-01 00:00:00

abstract：:Mice devoid of the original uncoupling protein UCP1 have provided opportunities to delineate UCP1 function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis....

journal_title：Biochemical Society transactions

authors： Nedergaard J,Golozoubova V,Matthias A,Shabalina I,Ohba K,Ohlson K,Jacobsson A,Cannon B

更新日期：2001-11-01 00:00:00

abstract：:Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood-brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage. These complications of early reperfusion, which result from excess production of ROS (reactive ox...

journal_title：Biochemical Society transactions

authors： Maier CM,Hsieh L,Crandall T,Narasimhan P,Chan PH

更新日期：2006-12-01 00:00:00

abstract：:Bacterial hydrogenases have been harnessed to the removal of heavy metals from solution by reduction to less soluble metal species. For Pd(II), its bioreduction results in the deposition of cell-bound Pd(0)-nanoparticles that are ferromagnetic and have a high catalytic activity. Hydrogenases can also be used synthetic...

journal_title：Biochemical Society transactions

authors： Macaskie LE,Baxter-Plant VS,Creamer NJ,Humphries AC,Mikheenko IP,Mikheenko PM,Penfold DW,Yong P

更新日期：2005-02-01 00:00:00

abstract：:The mechanical function and the collagen phenotype of the disc are complex, each a hybrid of elements of ligament and cartilage. In detail, the collagen properties are unique. Collagens I and II provide the bulk of the tissue fabric interwoven in opposing radial concentration gradients. From analysis of isolated cross...

journal_title：Biochemical Society transactions

authors： Eyre DR,Matsui Y,Wu JJ

更新日期：2002-11-01 00:00:00

abstract：:RNA pseudoknots are structural elements found in almost all classes of RNA. Pseudoknots form when a single-stranded region in the loop of a hairpin base-pairs with a stretch of complementary nucleotides elsewhere in the RNA chain. This simple folding strategy is capable of generating a large number of stable three-dim...

journal_title：Biochemical Society transactions

authors： Brierley I,Gilbert RJ,Pennell S

更新日期：2008-08-01 00:00:00

abstract：:With >800 members, G protein-coupled receptors (GPCRs) are the largest class of cell-surface signalling proteins, and their activation mediates diverse physiological processes. GPCRs are ubiquitously distributed across all cell types, involved in many diseases and are major drug targets. However, GPCR drug discovery i...

journal_title：Biochemical Society transactions

authors： Ellisdon AM,Halls ML

更新日期：2016-04-15 00:00:00

abstract：:The Kelch-like ECH associated protein 1 (Keap1)-NF-E2 p45-related factor 2 (Nrf2) pathway regulates networks of proteins that protect against the cumulative damage of oxidants, electrophiles and misfolded proteins. The interaction between transcription factor Nrf2 and its main negative cytoplasmic regulator Keap1 foll...

journal_title：Biochemical Society transactions

authors： Dinkova-Kostova AT,Baird L,Holmström KM,Meyer CJ,Abramov AY

更新日期：2015-08-01 00:00:00

abstract：:Mouse ES (embryonic stem) cells maintain pluripotency with robust proliferation in vitro. ES cells share some similarities with cancer cells, such as anchorage-independent growth, loss of contact inhibition and tumour formation. After differentiation, ES cells lose pluripotency and tumorigenicity. Recent studies showe...

journal_title：Biochemical Society transactions

authors： Takahashi K,Murakami M,Yamanaka S

更新日期：2005-12-01 00:00:00

abstract：:Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become clear that the LDs-confined deposition and lipolytic degradation of neut...

journal_title：Biochemical Society transactions

authors： Goldberg AA,Bourque SD,Kyryakov P,Boukh-Viner T,Gregg C,Beach A,Burstein MT,Machkalyan G,Richard V,Rampersad S,Titorenko VI

更新日期：2009-10-01 00:00:00

abstract：:Zebrafish (Danio rerio) are becoming an increasingly powerful model organism to study the role of metabolism in disease. Since its inception, the zebrafish model has relied on unique attributes such as the transparency of embryos, high fecundity and conservation with higher vertebrates, to perform phenotype-driven che...

journal_title：Biochemical Society transactions

authors： Salmi TM,Tan VWT,Cox AG

更新日期：2019-02-28 00:00:00

abstract：:Lipids are key molecules for membranes, energy storage and signalling. I have been privileged to have worked in such a diverse field and in organisms from microbes to humans. Here I will describe some of those contrasting areas which range from environmental impacts to food production and on to human health. It has be...

journal_title：Biochemical Society transactions

authors： Harwood JL

更新日期：2017-04-15 00:00:00

abstract：:One of the primary functions of AMP-activated protein kinase (AMPK) is to regulate the metabolic pathways in response to reduced cellular energy charge. Most of the known targets of the kinase are cytoplasmic enzymes involved in both catabolic and anabolic metabolism. In addition, activation of AMPK in many cells resu...

journal_title：Biochemical Society transactions

authors： Leff T

更新日期：2003-02-01 00:00:00

abstract：:The human prostate expresses very high concentrations of annexins 1, 4, and 5 and secretes high concentrations of annexins 1 and 5. Although the biological roles of these proteins in prostate secretions are not known, these studies emphasize the need to consider extracellular sites for physiological functions of annex...

journal_title：Biochemical Society transactions

authors： Haigler HT,Christmas P

更新日期：1990-12-01 00:00:00

abstract：:Mitochondria are central to the health of eukaryotic cells. While commonly known for their bioenergetic role, mitochondria also function as signaling organelles that regulate cell stress responses capable of restoring homeostasis or leading the stressed cell to eventual death. Damage to the plasma membrane is a potent...

journal_title：Biochemical Society transactions

authors： Horn A,Jaiswal JK

更新日期：2020-10-30 00:00:00

abstract：:Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the initiator of the coagulation cascade, Factor VIIa, binds to its cofactor, tissue factor, and its substrate, Factor X, via exosite interactions to form a ternary cata...

journal_title：Biochemical Society transactions

authors： Amour A,Hutchinson J,Ruiz Avendaño AM,Ratcliffe S,Alvarez E,Martin J,Toomey JR,Senger S,Wolfendale M,Mooney C

更新日期：2007-06-01 00:00:00

abstract：:The steroid hormone progesterone regulates many critical aspects of vertebrate physiology. The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression. This type of signalling is referred to as the 'genomic' pathway. Nevertheless, progesterone also st...

journal_title：Biochemical Society transactions

authors： Moussatche P,Lyons TJ

更新日期：2012-02-01 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the l...

journal_title：Biochemical Society transactions

authors： Urbé S,McCullough J,Row P,Prior IA,Welchman R,Clague MJ

更新日期：2006-11-01 00:00:00

abstract：:Lipoprotein oxidation is thought to play a pivotal role in the evolution of atherosclerosis. Low-density lipoprotein (LDL) is the main source of oxidized lipid in the arterial wall. Oxidation of LDL alters its properties in a number of ways, making it more atherogenic, but oxidation of other lipoprotein classes may al...

journal_title：Biochemical Society transactions

authors： Young IS,McFarlane C,McEneny J

更新日期：2003-10-01 00:00:00

abstract：:Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

journal_title：Biochemical Society transactions

authors： Falasca M,Maffucci T

更新日期：2007-04-01 00:00:00

abstract：:Haem (Fe-protoporphyrin IX) is a cofactor found in a wide variety of proteins. It confers diverse functions, including electron transfer, the binding and sensing of gases, and many types of catalysis. The majority of cofactors are non-covalently attached to proteins. There are, however, some proteins in which the cofa...

journal_title：Biochemical Society transactions

authors： Stevens JM,Uchida T,Daltrop O,Ferguson SJ

更新日期：2005-08-01 00:00:00

abstract：:A-type laminopathies are a group of diseases resulting from mutations in the intermediate filament proteins lamin A and C (both encoded by the LMNA gene), but for which the pathogenic mechanisms are little understood. In some laminopathies, there is a good correlation between the presence of a specific LMNA mutation a...

journal_title：Biochemical Society transactions

authors： Scharner J,Gnocchi VF,Ellis JA,Zammit PS

更新日期：2010-02-01 00:00:00

abstract：:AS (alternative splicing) is a post-transcriptional process which regulates gene expression through increasing protein complexity and modulating mRNA transcript levels. Regulation of AS depends on interactions between trans-acting protein factors and cis-acting signals in the pre-mRNA (precursor mRNA) transcripts, ter...

journal_title：Biochemical Society transactions

authors： Simpson CG,Manthri S,Raczynska KD,Kalyna M,Lewandowska D,Kusenda B,Maronova M,Szweykowska-Kulinska Z,Jarmolowski A,Barta A,Brown JW

更新日期：2010-04-01 00:00:00