Abstract:
:TRP (transient receptor potential) channels comprise a superfamily of non-selective cation channels with at least seven subfamilies. The variety of subfamilies corresponds to the differences in the activation mechanisms and functions. TRPM3 (TRP melastatin 3) and TRPV4 (TRP vanilloid 3) have been characterized as cation channels activated by extracellular hypo-osmoticity. In addition, TRPV4 is activated by metabolites of arachidonic acid as well as alpha-isomers of phorbol esters known to be ineffective in stimulating proteins of the protein kinase C family. TRPM3 is responsive to sphingosine derivatives. The detection of splice variants with probably different activation mechanisms supports the idea that TRPM3 may have diverse cellular functions depending on the expression of a particular variant. The expression of TRPV4 in many epithelial cell types raised the question of the role of TRPV4 in epithelial physiology. Single-cell experiments as well as approaches using epithelial layers show that multiple cellular responses are triggered by TRPV4 activation and subsequent elevation of intracellular calcium. The TRPV4-induced responses increasing transcellular ion flux as well as paracellular permeability may allow the cells to adjust to changes in extracellular osmolarity. In summary, TRPV4 plays a central role in epithelial homoeostasis by modulating epithelial barrier function.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Harteneck C,Reiter Bdoi
10.1042/BST0350091subject
Has Abstractpub_date
2007-02-01 00:00:00pages
91-5issue
Pt 1eissn
0300-5127issn
1470-8752pii
BST0350091journal_volume
35pub_type
杂志文章,评审abstract::Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases, which includes protein disulphide isomerase (PDI), ERp57, ERp72, P5 and PDIR....
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
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更新日期:1997-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0391493
更新日期:2011-10-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2008-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0280264
更新日期:2000-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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更新日期:2010-06-01 00:00:00
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journal_title:Biochemical Society transactions
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pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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更新日期:2006-02-01 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:2004-12-01 00:00:00
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更新日期:2016-02-01 00:00:00
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