Transferrin-mediated iron acquisition by pathogenic Neisseria.

abstract：:The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we rev...

journal_title：Biochemical Society transactions

authors： La Teana A,Benelli D,Londei P,Bläsi U

更新日期：2013-02-01 00:00:00

abstract：:Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel expressed in most central neurons, where it exists as a highly phosphorylated protein. Kv2.1 plays a critical role in homoeostatic regulation of intrinsic neuronal e...

journal_title：Biochemical Society transactions

authors： Mohapatra DP,Park KS,Trimmer JS

更新日期：2007-11-01 00:00:00

abstract：:The action of VEGF (vascular endothelial growth factor) is essential to maintain proper endothelial and vascular function. VEGF stimulates virtually all aspects of endothelial function, namely proliferation, migration, permeability and nitric oxide production and release. In addition, the action of VEGF makes the endo...

journal_title：Biochemical Society transactions

authors： Waltenberger J

更新日期：2009-12-01 00:00:00

abstract：:Protein phosphatase-6 (PP6) is a member of the PPP family of Ser/Thr phosphatases involved in intracellular signaling. PP6 is conserved among all eukaryotes, and genetics in model organisms indicates it has non-redundant functions relative to other PPP phosphatases. PP6 functions in association with conserved SAPS sub...

journal_title：Biochemical Society transactions

authors： Ziembik MA,Bender TP,Larner JM,Brautigan DL

更新日期：2017-06-15 00:00:00

abstract：:The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is conver...

journal_title：Biochemical Society transactions

authors： Mori K

更新日期：2003-02-01 00:00:00

abstract：:This review focuses on recent insights into the mechanisms and the biological functions of the proteasome. This large ATP-dependent proteolytic complex is the main site for protein degradation in mammalian cells and catalyses the rapid degradation of ubiquitinated proteins, and is the source of most antigenic peptides...

journal_title：Biochemical Society transactions

authors： Goldberg AL

更新日期：2007-02-01 00:00:00

abstract：:Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their...

journal_title：Biochemical Society transactions

authors： Venkatakrishnan AJ,Levy ED,Teichmann SA

更新日期：2010-08-01 00:00:00

abstract：:It is generally taken as an established fact that mitochondrial respiration is associated with the generation of small amounts of ROS (reactive oxygen species). There are many arguments supporting this side activity. A major argument is the particular physico-chemical configuration of dioxygen, which prevents the tran...

journal_title：Biochemical Society transactions

authors： Nohl H,Kozlov AV,Gille L,Staniek K

更新日期：2003-12-01 00:00:00

abstract：:Sorting of activated epidermal growth factor receptor (EGFR) into intraluminal vesicles (ILVs) within the multivesicular body (MVB) is an essential step during the down-regulation of the receptor. The machinery that drives EGFR sorting attaches to the cytoplasmic face of the endosome and generates vesicles that bud in...

journal_title：Biochemical Society transactions

authors： Tabernero L,Woodman P

更新日期：2018-10-19 00:00:00

abstract：:Accumulating evidence indicates that beta-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that beta-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcript...

journal_title：Biochemical Society transactions

authors： Eizirik DL,Moore F,Flamez D,Ortis F

更新日期：2008-06-01 00:00:00

abstract：:In this work we present a probabilistic model to estimate summaries of Affymetrix GeneChip probe level data. Comparisons with two different models were made both on a publicly available dataset and on a study performed in our laboratory, showing that our model performs better for consistency of fold change. ...

journal_title：Biochemical Society transactions

authors： Milo M,Fazeli A,Niranjan M,Lawrence ND

更新日期：2003-12-01 00:00:00

abstract：:RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors). Specifically for the CT (calcitonin) receptor-like receptor and the CT receptor, this results in profound changes in ligand binding and receptor pharmacology, al...

journal_title：Biochemical Society transactions

authors： Conner AC,Simms J,Hay DL,Mahmoud K,Howitt SG,Wheatley M,Poyner DR

更新日期：2004-11-01 00:00:00

abstract：:Stimulus-response coupling in animal cells frequently involves the hydrolysis of PtdIns(4,5)P(2) which is catalysed by phosphoinositide-specific phospholipase C (PI-PLC). There is an increasing body of evidence for PI-PLC-based signalling in plant cells; however, the physiological role of this system remains poorly do...

journal_title：Biochemical Society transactions

authors： Coursol S,Pierre JN,Vidal J

更新日期：2000-12-01 00:00:00

abstract：:In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein-protein interactions of regulatory multiprotein assemblies. Protein-protein interfaces are widely recognized to be challenging targets as...

journal_title：Biochemical Society transactions

authors： Abdel-Rahman N,Martinez-Arias A,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:We have shown that yeast mutants with defects in the Ada adaptor proteins are defective in hormone-dependent gene activation by ectopically expressed human glucocorticoid receptor (GR). Others have shown that the Ada2 protein is required for physical interactions between some activation domains and TBP (TATA-binding p...

journal_title：Biochemical Society transactions

authors： Wallberg AE,Flinn EM,Gustafsson JA,Wright AP

更新日期：2000-01-01 00:00:00

abstract：:We have described a large number of different mutations in the LPL gene that result in completely catalytically defective LPL protein. More recently exonic polymorphisms in the LPL gene have been described that do not result in the catalytic activity of LPL being significantly impaired. Furthermore we have recently de...

journal_title：Biochemical Society transactions

authors： Hayden MR,Kastelein JJ,Funke H,Brunzell JD,Ma Y

更新日期：1993-05-01 00:00:00

abstract：:One of the major goals of modern plant biotechnology is to manipulate lipid metabolism in oilseed crops to produce new and improved edible and industrial vegetable oils. Lipids constitute the structural components of cellular membranes and act as sources of energy for the germinating seed and are therefore essential t...

journal_title：Biochemical Society transactions

authors： Schnurr JA,Shockey J,Browse J

更新日期：2000-12-01 00:00:00

abstract：:The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summar...

journal_title：Biochemical Society transactions

authors： Tissier A,Frank EG,McDonald JP,Vaisman A,Fernàndez de Henestrosa AR,Boudsocq F,McLenigan MP,Woodgate R

更新日期：2001-05-01 00:00:00

abstract：:In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

journal_title：Biochemical Society transactions

authors： Gnaiger E,Kuznetsov AV

更新日期：2002-04-01 00:00:00

abstract：:The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most extensively studied membrane protein transporter. There is a vast array of diverse inhibitors for the Ca2+ pump, and many have proved significant in helping to elucidate both the mechanism of transport and gaining conformational structures...

journal_title：Biochemical Society transactions

authors： Michelangeli F,East JM

更新日期：2011-06-01 00:00:00

abstract：:We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors. These two peptides containing an Asp residue at position 3 interacted with an arginine residue in transmembrane helix 2 (TM2) of the receptor, and the lysine r...

journal_title：Biochemical Society transactions

authors： Waelbroeck M,Perret J,Vertongen P,Van Craenenbroeck M,Robberecht P

更新日期：2002-08-01 00:00:00

abstract：:The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to a...

journal_title：Biochemical Society transactions

authors： Conigrave AD,Mun HC,Brennan SC

更新日期：2007-11-01 00:00:00

abstract：:Many proteins self-assemble to form large supramolecular complexes. Numerous examples of these structures have been characterized, ranging from spherical viruses to tubular protein assemblies. Some new kinds of supramolecular structures are just coming to light, while it is likely there are others that have not yet be...

journal_title：Biochemical Society transactions

authors： Yeates TO,Tsai Y,Tanaka S,Sawaya MR,Kerfeld CA

更新日期：2007-06-01 00:00:00

abstract：:The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped. A common set of IgG1 residues is involved in binding to all Fc gamma Rs, while Fc gamma RII and Fc gamma RIII utilize distinct sites outside this common set. In ad...

journal_title：Biochemical Society transactions

authors： Presta LG,Shields RL,Namenuk AK,Hong K,Meng YG

更新日期：2002-08-01 00:00:00

abstract：:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP produc...

journal_title：Biochemical Society transactions

authors： Aerts L,De Strooper B,Morais VA

更新日期：2015-04-01 00:00:00

abstract：:14-3-3 proteins are involved in signalling processes in neuronal cells. Using isoform-specific antibodies we have examined the variation in 14-3-3 isoform neurolocation in normal and scrapie-infected murine brain and show that in defined areas of the brain there are significant changes associated with the pathology of...

journal_title：Biochemical Society transactions

authors： Baxter HC,Fraser JR,Liu WG,Forster JL,Clokie S,Steinacker P,Otto M,Bahn E,Wiltfang J,Aitken A

更新日期：2002-08-01 00:00:00

abstract：:The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and appar...

journal_title：Biochemical Society transactions

authors： Hölttä-Vuori M,Ikonen E

更新日期：2006-06-01 00:00:00

abstract：:Large single crystals (up to 1 mm in each dimension) of the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050 have been grown in the presence of beta-octyl-glucoside. These crystals have the space group R32 and unit cell dimensions of a = b = 119.9 A and c = 297.0 A. Recently we have improved our ...

journal_title：Biochemical Society transactions

authors： Cogdell RJ,Halloren E,Hawthornthwaite AM,Thunnissen MM,Freer AA,McDermott G,Guthrie N,Isaacs N,Lindsay JG,Papiz M

更新日期：1993-02-01 00:00:00

abstract：:Reciprocal biochemical and biophysical interactions between tumor cells, stromal cells and the extracellular matrix (ECM) result in a unique tumor microenvironment that determines disease outcome. The cellular component of the tumor microenvironment contributes to tumor growth by providing nutrients, assisting in the ...

journal_title：Biochemical Society transactions

authors： Johan MZ,Samuel MS

更新日期：2019-02-28 00:00:00

abstract：:Squalene epoxidase (Erg1p) is an essential enzyme in the ergosterol biosynthesis pathway in yeast. For its enzymatic activity, Erg1p requires molecular oxygen, NAD(P)H and FAD. Amino acid analysis and sequence alignment with other squalene epoxidases revealed two highly conserved FAD-binding domains, FAD I and FAD II....

journal_title：Biochemical Society transactions

authors： Ruckenstuhl C,Eidenberger A,Lang S,Turnowsky F

更新日期：2005-11-01 00:00:00