Abstract:
:Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their assembly in solution.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Venkatakrishnan AJ,Levy ED,Teichmann SAdoi
10.1042/BST0380879subject
Has Abstractpub_date
2010-08-01 00:00:00pages
879-82issue
4eissn
0300-5127issn
1470-8752pii
BST0380879journal_volume
38pub_type
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更新日期:2007-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20200250
更新日期:2020-11-27 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2019-10-31 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2020-08-28 00:00:00
abstract::PTEN (phosphatase and tensin homologue deleted on chromosome 10) is an important tumour-suppressor gene that encodes a 3-phosphatase. The major substrate of PTEN is PIP(3) (phosphatidylinositol 3,4,5-trisphosphate) generated by the action of PI3Ks (phosphoinositide 3-kinases). Hereditary mutation of PTEN causes tumour...
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2000-12-01 00:00:00
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