Roles of PPARdelta in the control of muscle development and metabolism.

abstract：:Pancreatic cancer is the fourth most common cause of death from cancer in the world and the sixth in Europe. Pancreatic cancer is more frequent in males than females. Worldwide, following diagnosis of pancreatic cancer, <2% of patients survive for 5 years, 8% survive for 2 years and <50% survive for only approx. 3 mon...

journal_title：Biochemical Society transactions

authors： Szajda SD,Waszkiewicz N,Chojnowska S,Zwierz K

更新日期：2011-01-01 00:00:00

abstract：:In plants, the spatial arrangement of cells within tissues and organs is a direct consequence of the positioning of the new cell walls during cell division. Since the nineteenth century, scientists have proposed rules to explain the orientation of plant cell divisions. Most of these rules predict the new wall will fol...

journal_title：Biochemical Society transactions

authors： Serra L,Robinson S

更新日期：2020-12-18 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-dis...

journal_title：Biochemical Society transactions

authors： Civiero L,Cogo S,Biosa A,Greggio E

更新日期：2018-12-17 00:00:00

abstract：:Colicins are protein antibiotics produced by Escherichia coli to kill closely related non-identical competing species. They have taken advantage of the promiscuity of several proteins in the cell envelope for entry into the bacterial cell. The Tol-Pal system comprises one such ensemble of periplasmic and membrane-asso...

journal_title：Biochemical Society transactions

authors： Penfold CN,Li C,Zhang Y,Vankemmelbeke M,James R

更新日期：2012-12-01 00:00:00

abstract：:A flavorubredoxin and its associated oxidoreductase (encoded by norV and norW respectively) detoxify NO (nitric oxide) to form N2O (nitrous oxide) under anaerobic conditions in Escherichia coli. Transcription of the norVW genes is activated in response to NO by the σ54-dependent regulator and dedicated NO sensor, NorR...

journal_title：Biochemical Society transactions

authors： Bush M,Ghosh T,Tucker N,Zhang X,Dixon R

更新日期：2011-01-01 00:00:00

abstract：:Based on recent theoretical results on optimal flux distributions in kinetic metabolic networks, we explore the congruences and differences between solutions of kinetic optimization problems and results obtained by constraint-based methods. We demonstrate that, for a certain resource allocation problem, kinetic optimi...

journal_title：Biochemical Society transactions

authors： Müller S,Regensburger G,Steuer R

更新日期：2015-12-01 00:00:00

abstract：:The interaction of chemokines and GAGs (glycosaminoglycans) on endothelial surfaces is a crucial step for establishing a chemotactic gradient which leads to the functional presentation of chemokines to their GPCRs (G-protein-coupled receptors) and thus to activation of approaching leucocytes. Based on molecular modell...

journal_title：Biochemical Society transactions

authors： Potzinger H,Geretti E,Brandner B,Wabitsch V,Piccinini AM,Rek A,Kungl AJ

更新日期：2006-06-01 00:00:00

abstract：:The role of Hsp70 (heat-shock protein 70) chaperones in assisting protein-folding processes relies on their ability to associate with short peptide stretches of protein substrates in a transient and ATP-controlled manner. In the present study, we review the molecular details of the mechanism behind substrate recogniti...

journal_title：Biochemical Society transactions

authors： Erbse A,Mayer MP,Bukau B

更新日期：2004-08-01 00:00:00

abstract：:Yeast cells rely on the SPS-sensing pathway to respond to extracellular amino acids. This nutrient-induced signal transduction pathway regulates gene expression by controlling the activity of two redundant transcription factors: Stp1 and Stp2. These factors are synthesized as latent cytoplasmic proteins with N-termina...

journal_title：Biochemical Society transactions

authors： Ljungdahl PO

更新日期：2009-02-01 00:00:00

abstract：:Experimental processes in the life sciences are becoming increasingly complex. As a result, recording, archiving and sharing descriptions of these processes and of the results of experiments is becoming ever more challenging. However, validation of results, sharing of best practice and integrated analysis all require ...

journal_title：Biochemical Society transactions

authors： Paton NW

更新日期：2008-02-01 00:00:00

abstract：:Nitric oxide is an intermediate of denitrification, and is one of the radical species deployed by macrophages against invading pathogens, therefore bacterial responses to NO are of considerable importance. The Escherichia coli flavorubredoxin and its associated oxidoreductase reduce NO to nitrous oxide under anaerobic...

journal_title：Biochemical Society transactions

authors： Tucker N,D'autréaux B,Spiro S,Dixon R

更新日期：2005-02-01 00:00:00

abstract：:The identification of nitric oxide-bound leghaemoglobin within soya bean nodules has led to the question of how Bradyrhizobium japonicum bacteroids overcome the toxicity of this nitric oxide. It has previously been shown that one candidate for nitric oxide detoxification, the respiratory nitric oxide reductase, is exp...

journal_title：Biochemical Society transactions

authors： Meakin GE,Jepson BJ,Richardson DJ,Bedmar EJ,Delgado MJ

更新日期：2006-02-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is the causative agent of chicken pox (varicella) and shingles (zoster). Although considered benign diseases, both varicella and zoster can cause complications. Zoster is painful and can lead to post herpetic neuralgia. VZV has also been linked to stroke, related to giant cell arteritis in...

journal_title：Biochemical Society transactions

authors： Oliver SL,Zhou M,Arvin AM

更新日期：2020-12-01 00:00:00

abstract：:CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In...

journal_title：Biochemical Society transactions

authors： Elmore JP,McGee MC,Nidetz NF,Anannya O,Huang W,August A

更新日期：2020-02-28 00:00:00

abstract：:The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in epigenetic gene silencing. Variations in the SMCHD1 gene are associated with two debilitating human disorders, facioscapulohumeral muscular dystrophy (FSHD) and Bosma arhinia microphthalmia s...

journal_title：Biochemical Society transactions

authors： Gurzau AD,Blewitt ME,Czabotar PE,Murphy JM,Birkinshaw RW

更新日期：2020-08-28 00:00:00

abstract：:The respiratory complex I (electrogenic NADH:quinone oxidoreductase) has been considered to act exclusively as a H+ pump. This was questioned when the search for the NADH-driven respiratory Na+ pump in Klebsiella pneumoniae initiated by Peter Dimroth led to the discovery of a Na+-translocating complex in this enteroba...

journal_title：Biochemical Society transactions

authors： Steffen W,Steuber J

更新日期：2013-10-01 00:00:00

abstract：:Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's disease (AD) are associated with synaptic dysfunction, neuronal death and cognitive and behavioural deficits. Neuroinflammation is also a prominent feature of AD brain and considerable evidence indicates that inflammatory event...

journal_title：Biochemical Society transactions

authors： Phillips EC,Croft CL,Kurbatskaya K,O'Neill MJ,Hutton ML,Hanger DP,Garwood CJ,Noble W

更新日期：2014-10-01 00:00:00

abstract：:Rho-family GTPases regulate various aspects of cell function by controlling cytoskeletal changes; however, their spatial regulation within the cells remains largely unknown. To understand this regulation, we have studied the spatiotemporal activity of Rho-family GTPases in migrating cells and growth factor-stimulated ...

journal_title：Biochemical Society transactions

authors： Kurokawa K,Nakamura T,Aoki K,Matsuda M

更新日期：2005-08-01 00:00:00

abstract：:Colorectal cancer is the third most common cancer in developed countries such as the U.K., but incidence rates around the world vary approx. 20-fold. Diet is thought to be a key factor determining risk: red and processed meat, but not white meat or fish, are associated with an increased risk of colorectal cancer. The ...

journal_title：Biochemical Society transactions

authors： Kuhnle GG,Bingham SA

更新日期：2007-11-01 00:00:00

abstract：:Studies on those enzymes and electron-transfer proteins involved in the catabolism of 'C1' substrates in methylotrophic bacteria have provided a wealth of information concerning the transfer of electrons and hydrogen by quantum tunnelling mechanisms. With regard to H-transfer, studies with MADH have provided the first...

journal_title：Biochemical Society transactions

authors： Scrutton NS

更新日期：1999-12-01 00:00:00

abstract：:In this work we present a probabilistic model to estimate summaries of Affymetrix GeneChip probe level data. Comparisons with two different models were made both on a publicly available dataset and on a study performed in our laboratory, showing that our model performs better for consistency of fold change. ...

journal_title：Biochemical Society transactions

authors： Milo M,Fazeli A,Niranjan M,Lawrence ND

更新日期：2003-12-01 00:00:00

abstract：:The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned s...

journal_title：Biochemical Society transactions

authors： Carmena M

更新日期：2008-06-01 00:00:00

abstract：:Site-specific recombinases are enzymes that promote precise rearrangements of DNA sequences. They do this by cutting and rejoining the DNA strands at specific positions within a pair of target sites recognized and bound by the recombinase. One group of these enzymes, the serine recombinases, initiates strand exchange ...

journal_title：Biochemical Society transactions

authors： Marshall Stark W,Boocock MR,Olorunniji FJ,Rowland SJ

更新日期：2011-04-01 00:00:00

abstract：:The axial ligand of the catalytic mononuclear T1 copper site (Met(502)) of the CotA laccase was replaced by a leucine or phenylalanine residue to increase the redox potential of the enzyme. These mutations led to an increase in the redox potential by approx. 100 mV relative to the wild-type enzyme but the catalytic co...

journal_title：Biochemical Society transactions

authors： Melo EP,Fernandes AT,Durão P,Martins LO

更新日期：2007-12-01 00:00:00

abstract：:Metabolic and epidemiologic studies support the idea that the type of dietary fat is more important than the total amount of fat with respect to the development of atherosclerosis and the risk of cardiovascular heart disease. Dietary fat is carried in CMs (chylomicrons), which can be taken up by macrophages without ne...

journal_title：Biochemical Society transactions

authors： Cabello-Moruno R,Perona JS,Ruiz-Gutierrez V

更新日期：2007-06-01 00:00:00

abstract：:Genetic experiments have indicated that succinoglycan (EPS I), the acidic Calcofluor-binding exopolysaccharide, of the nitrogen-fixing bacterium Rhizobium meliloti strain Rm1021 is required for nodule invasion and possibly for later events in nodule development on alfalfa and other hosts. Fourteen exo loci on the seco...

journal_title：Biochemical Society transactions

authors： Reuber TL,Reed J,Glazebrook J,Glucksmann MA,Ahmann D,Marra A,Walker GC

更新日期：1991-08-01 00:00:00

abstract：:Photosynthesis is fundamental to biomass production, but is a dynamic process sensitive to environmental constraints. In recent years, approaches to increase biomass and grain yield by altering photosynthetically related processes in the plant have received considerable attention. However, improving biomass yield requ...

journal_title：Biochemical Society transactions

authors： Heyneke E,Fernie AR

更新日期：2018-04-17 00:00:00

abstract：:Chlorophyll metabolism is probably the most visible manifestation of life. In spite of this, chlorophyll catabolism has remained something of a mystery until about 10 years ago. At that time, the first non-green tetrapyrrolic chlorophyll breakdown products from higher plants were discovered, and the structure of the f...

journal_title：Biochemical Society transactions

authors： Kräutler B

更新日期：2002-08-01 00:00:00

abstract：:We report a novel, highly sensitive and selective method for the detection and quantification of acyl-CoA esters from Arabidopsis thaliana. Extracted acyl-CoA esters were derived to their fluorescent acyl-etheno-CoA esters, separated by ion-paired reversed-phase HPLC, and detected fluorometrically. We report the compo...

journal_title：Biochemical Society transactions

authors： Larson TR,Graham IA

更新日期：2000-12-01 00:00:00

abstract：:Squalene epoxidase (Erg1p) is an essential enzyme in the ergosterol biosynthesis pathway in yeast. For its enzymatic activity, Erg1p requires molecular oxygen, NAD(P)H and FAD. Amino acid analysis and sequence alignment with other squalene epoxidases revealed two highly conserved FAD-binding domains, FAD I and FAD II....

journal_title：Biochemical Society transactions

authors： Ruckenstuhl C,Eidenberger A,Lang S,Turnowsky F

更新日期：2005-11-01 00:00:00