Unravelling chlorophyll catabolism in higher plants.

abstract：:We have described a large number of different mutations in the LPL gene that result in completely catalytically defective LPL protein. More recently exonic polymorphisms in the LPL gene have been described that do not result in the catalytic activity of LPL being significantly impaired. Furthermore we have recently de...

journal_title：Biochemical Society transactions

authors： Hayden MR,Kastelein JJ,Funke H,Brunzell JD,Ma Y

更新日期：1993-05-01 00:00:00

abstract：:Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be...

journal_title：Biochemical Society transactions

authors： Semb H

更新日期：2008-06-01 00:00:00

abstract：:Lipids are key molecules for membranes, energy storage and signalling. I have been privileged to have worked in such a diverse field and in organisms from microbes to humans. Here I will describe some of those contrasting areas which range from environmental impacts to food production and on to human health. It has be...

journal_title：Biochemical Society transactions

authors： Harwood JL

更新日期：2017-04-15 00:00:00

abstract：:CoA (coenzyme A) is a ubiquitous and essential cofactor that acts as an acyl group carrier in biochemical reactions. Apart from participating in numerous metabolic pathways as substrates and intermediates, CoA and a number of its thioester derivatives, such as acetyl-CoA, can also directly regulate the activity of pro...

journal_title：Biochemical Society transactions

authors： Tsuchiya Y,Pham U,Gout I

更新日期：2014-08-01 00:00:00

abstract：:Mutations in MYO7A (myosin VIIa) cause Usher syndrome type 1B, a disorder involving profound congenital deafness and progressive blindness. In the retina, most MYO7A is localized in the apical region of the RPE (retinal pigmented epithelial) cells, and a small amount is associated with the ciliary and periciliary memb...

journal_title：Biochemical Society transactions

authors： Williams DS,Lopes VS

更新日期：2011-10-01 00:00:00

abstract：:XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that repairs DNA DSBs (double-strand breaks). The individual crystal structures show that the dimeric proteins are homologues with protomers containing h...

journal_title：Biochemical Society transactions

authors： Wu Q,Ochi T,Matak-Vinkovic D,Robinson CV,Chirgadze DY,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is conver...

journal_title：Biochemical Society transactions

authors： Mori K

更新日期：2003-02-01 00:00:00

abstract：:Mammalian peroxisomes degrade fatty carboxylates via two pathways, beta-oxidation and, as shown more recently, alpha-oxidation. The latter process consists of an activation step, followed by a hydroxylation at position 2 and cleavage of the 2-hydroxyacyl-CoA, generating formyl-CoA (precursor of formate/CO(2)) and, in ...

journal_title：Biochemical Society transactions

authors： Van Veldhoven PP,Casteels M,Mannaerts GP,Baes M

更新日期：2001-05-01 00:00:00

abstract：:Moonlighting proteins serve one or more novel functions in addition to their canonical roles. Moonlighting functions arise when an adventitious interaction between a protein and a new partner improves fitness of the organism. Selective pressure for improvement in the new function can result in two alternative outcomes...

journal_title：Biochemical Society transactions

authors： Copley SD

更新日期：2014-12-01 00:00:00

abstract：:mRNA instability is an intrinsic property that permits timely changes in gene expression by limiting the lifetime of a transcript. The RNase e of Escherichia coli is a single-strand-specific endo-nuclease involved in the processing of rRNA and the degradation of mRNA. A nucleolytic multi-enzyme complex now known as th...

journal_title：Biochemical Society transactions

authors： Carpousis AJ

更新日期：2002-04-01 00:00:00

abstract：:From a protein structural viewpoint, tryptophan is often considered an inert structural amino acid, playing a role as a hydrophobic anchor in membrane proteins or as part of the hydrophobic core of soluble proteins. However, tryptophan is the only polyaromatic amino acid and, from a chemical viewpoint, possesses uniqu...

journal_title：Biochemical Society transactions

authors： Naismith JH

更新日期：2012-06-01 00:00:00

abstract：:The revolution of genomics and growth of systems biology urged the creation of synthetic biology, an engineering discipline aiming at recreating and reprogramming cellular functions for industrial needs. There has been a huge effort in synthetic biology to develop versatile and programmable genetic regulators that wou...

journal_title：Biochemical Society transactions

authors： Apura P,Domingues S,Viegas SC,Arraiano CM

更新日期：2019-10-31 00:00:00

abstract：:The mitochondrial outer membrane separates the intermembrane space from the cytosol. The whole exchange of metabolites, cations and information between mitochondria and the cell occurs through the outer membrane. Experimental evidence is reviewed supporting the hypothesis of dynamic ADP compartmentation within the int...

journal_title：Biochemical Society transactions

authors： Gellerich FN,Trumbeckaite S,Opalka JR,Seppet E,Rasmussen HN,Neuhoff C,Zierz S

更新日期：2000-02-01 00:00:00

abstract：:NRs (nuclear receptors) regulate the expression of specific gene networks in target cells by recruiting cofactor complexes involved in chromatin remodelling and in the assembly of transcription complexes. The importance of activating gene expression, in metabolic tissues, is well established, but the contribution of t...

journal_title：Biochemical Society transactions

authors： Parker MG,Christian M,White R

更新日期：2006-12-01 00:00:00

abstract：:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP produc...

journal_title：Biochemical Society transactions

authors： Aerts L,De Strooper B,Morais VA

更新日期：2015-04-01 00:00:00

abstract：:Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

journal_title：Biochemical Society transactions

authors： Wagner S,Breiteneder H

更新日期：2002-11-01 00:00:00

abstract：:Glucotoxicity plays a major role in pancreatic beta-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic beta-cell factor that is induced by glucose, suggesting that TXNIP may...

journal_title：Biochemical Society transactions

authors： Shalev A

更新日期：2008-10-01 00:00:00

abstract：:The continuous battle for survival in the environment has led to the development or acquisition of sophisticated defence systems in bacteria. These defence systems have contributed to the survival of the bacterial species in the environment for millions of years. Some systems appear to have evolved in a number of path...

journal_title：Biochemical Society transactions

authors： Louwen R,van Baarlen P

更新日期：2013-12-01 00:00:00

abstract：:Vibrational changes in the catalytic site of horseradish peroxidase were investigated by FTIR (Fourier-transform infrared) spectroscopy in the 1000-2500 cm(-1) range. Difference spectra were generated by photolysis of the haemII-CO compound at different pH/pD values. The spectra report on the fine structure around the...

journal_title：Biochemical Society transactions

authors： Ingledew WJ,Rich PR

更新日期：2005-08-01 00:00:00

abstract：:Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

journal_title：Biochemical Society transactions

authors： Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

更新日期：2017-04-15 00:00:00

abstract：:Mutation of the ACN1 (acetate non-utilizing 1) locus of Arabidopsis results in altered acetate assimilation into gluconeogenic sugars and anapleurotic amino acids and leads to an overall depression in primary metabolite levels by approx. 50% during seedling development. Levels of acetyl-CoA were higher in acn1 compare...

journal_title：Biochemical Society transactions

authors： Hooks MA,Allen E,Wattis JA

更新日期：2010-10-01 00:00:00

abstract：:Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. O...

journal_title：Biochemical Society transactions

authors： Mueller C,Schwender J,Zeidler J,Lichtenthaler HK

更新日期：2000-12-01 00:00:00

abstract：:Cellular membranes communicate extensively via contact sites that form between two membranes. Such sites allow exchange of specific ions, lipids or proteins between two compartments without content mixing, thereby preserving organellar architecture during the transfer process. Even though the molecular compositions of...

journal_title：Biochemical Society transactions

authors： Raiborg C,Wenzel EM,Pedersen NM,Stenmark H

更新日期：2016-04-15 00:00:00

abstract：:Sucrose non-fermenting 1 (Snf1) protein kinase, a yeast homologue of mammalian AMP-activated protein kinase, plays a main role in transcriptional activation and repression of gene expression. In addition, Snf1 kinase has a broad role in the cellular response to several forms of stress, such as nutrient limitation, sal...

journal_title：Biochemical Society transactions

authors： Sanz P

更新日期：2003-02-01 00:00:00

abstract：:The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

journal_title：Biochemical Society transactions

authors： Dalgleish R

更新日期：1988-10-01 00:00:00

abstract：:The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. Deciphering these codes is very challenging due to the large number of variables involved, the non-modular nature of the codes, biases and limitations in current experimental approaches, our limited knowledge in gen...

journal_title：Biochemical Society transactions

authors： Bahiri-Elitzur S,Tuller T

更新日期：2020-08-28 00:00:00

abstract：:Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the uniq...

journal_title：Biochemical Society transactions

authors： Inagami T,Misono KS,Chang JJ,Takii Y

更新日期：1984-12-01 00:00:00

abstract：:It has been clear for some time now that mucin glycoproteins have extensive, highly glycosylated tandem repeat domains. What is becoming increasingly apparent, however, is the diversity of unique sequences present on different mucins. Variations in mucin-unique sequences clearly result in major differences in physical...

journal_title：Biochemical Society transactions

authors： Gum JR Jr

更新日期：1995-11-01 00:00:00

abstract：:The Ca2+-mobilizing second messenger, NAADP (nicotinic acid adenine dinucleotide phosphate), has been with us for nearly 20 years and yet we still cannot fully agree on the identity of its target Ca2+-release channel. In spite of some recent robust challenges to the idea that two-pore channels (TPCs) represent the elu...

journal_title：Biochemical Society transactions

authors： Morgan AJ,Davis LC,Ruas M,Galione A

更新日期：2015-06-01 00:00:00

abstract：:One of the major goals of modern plant biotechnology is to manipulate lipid metabolism in oilseed crops to produce new and improved edible and industrial vegetable oils. Lipids constitute the structural components of cellular membranes and act as sources of energy for the germinating seed and are therefore essential t...

journal_title：Biochemical Society transactions

authors： Schnurr JA,Shockey J,Browse J

更新日期：2000-12-01 00:00:00