Abstract:
:Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well-established roles of LRRK2 in intracellular trafficking pathways and outgrowth of neuronal processes in health and disease conditions.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Civiero L,Cogo S,Biosa A,Greggio Edoi
10.1042/BST20180469subject
Has Abstractpub_date
2018-12-17 00:00:00pages
1653-1663issue
6eissn
0300-5127issn
1470-8752pii
BST20180469journal_volume
46pub_type
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