Abstract:
:The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules. In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Cooper CD,Newman JA,Gileadi Odoi
10.1042/BST20130227subject
Has Abstractpub_date
2014-02-01 00:00:00pages
130-8issue
1eissn
0300-5127issn
1470-8752pii
BST20130227journal_volume
42pub_type
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