Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

Abstract:

:The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules. In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future.

journal_name

Biochem Soc Trans

authors

Cooper CD,Newman JA,Gileadi O

doi

10.1042/BST20130227

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

130-8

issue

1

eissn

0300-5127

issn

1470-8752

pii

BST20130227

journal_volume

42

pub_type

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