Abstract:
:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction), and recent experimental evidence suggests that these changes contribute directly to the restricted fetal growth. We have shown that mTOR regulates the activity of the placental L-type amino acid transporter system and that placental mTOR activity is decreased in IUGR. The present review summarizes the emerging evidence implicating placental mTOR signalling as a key mechanism linking maternal nutrient and growth factor concentrations to amino acid transport in the human placenta. Since fetal growth is critically dependent on placental nutrient transport, placental mTOR signalling plays an important role in the regulation of fetal growth.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Roos S,Powell TL,Jansson Tdoi
10.1042/BST0370295subject
Has Abstractpub_date
2009-02-01 00:00:00pages
295-8issue
Pt 1eissn
0300-5127issn
1470-8752pii
BST0370295journal_volume
37pub_type
杂志文章,评审abstract::CT responds to properties of PC-depleted membranes: increased negative charge density, which concentrates the enzyme at the membrane surface, and lipid packing perturbations, which create holes in the membrane surface into which the hydrophobic side chains of the amphipathic helix of domain M can intercalate. The PC-d...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0360534
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0310452
更新日期:2003-04-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/
更新日期:2002-04-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2019-08-30 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/0300-5127:0280601
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
abstract::Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's disease (AD) are associated with synaptic dysfunction, neuronal death and cognitive and behavioural deficits. Neuroinflammation is also a prominent feature of AD brain and considerable evidence indicates that inflammatory event...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2017-12-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00