Abstract:
:Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neutrophils gradually lose the anti-apoptotic protein Mcl-1 and Bax translocates and inserts into the mitochondrial membrane. However, other reports show that caspase 8 is required for neutrophil apoptosis, suggesting the involvement of DR (death receptor) signalling. As DR ligation is not required for neutrophil apoptosis, this raises the intriguing possibility that activation of caspase 8 during neutrophil apoptosis occurs via a novel mechanism. In the present paper, we discuss the current evidence for mechanisms occurring in neutrophil apoptosis, which could trigger DR signalling in the absence of DR ligation.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Scheel-Toellner D,Wang KQ,Webb PR,Wong SH,Craddock R,Assi LK,Salmon M,Lord JMdoi
10.1042/BST0320461keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
461-4issue
Pt3eissn
0300-5127issn
1470-8752pii
BST0320461journal_volume
32pub_type
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