Abstract:
:The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we review the current knowledge of the structure, function and evolution of the IFs in S. solfataricus in the context of eukaryotic and bacterial orthologues. Despite similarities between eukaryotic and S. solfataricus IFs, the sequence of events in translation initiation in S. solfataricus follows the bacterial mode.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
La Teana A,Benelli D,Londei P,Bläsi Udoi
10.1042/BST20120300subject
Has Abstractpub_date
2013-02-01 00:00:00pages
350-5issue
1eissn
0300-5127issn
1470-8752pii
BST20120300journal_volume
41pub_type
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