New aspects in cardiac L-type Ca2+ channel regulation.

Abstract:

:Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with the channel and is one of the main regulators of its function. Whether this kinase is modulating the channel open probability by phosphorylation of key residues or via alternative mechanisms is unclear. This review summarizes recent findings regarding the PKA-mediated channel modulation and will highlight recently discovered regulatory mechanisms that are independent of PKA activity and involve protein-protein interactions and channel localization.

journal_name

Biochem Soc Trans

authors

Pallien T,Klussmann E

doi

10.1042/BST20190229

subject

Has Abstract

pub_date

2020-02-28 00:00:00

pages

39-49

issue

1

eissn

0300-5127

issn

1470-8752

pii

222144

journal_volume

48

pub_type

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