Regulation of gene expression by the RNA-binding protein Sam68 in cancer.

abstract：:Human adipose tissue has an important protein secretory function. Cytokines, hormones, prohormones and enzymes are secreted from fat cells and act in an endocrine or paracrine fashion. The production of several of these proteins is affected by obesity; normally there is an increase in the obese state. Protein producti...

journal_title：Biochemical Society transactions

authors： Arner P

更新日期：2001-05-01 00:00:00

abstract：:The progression of Type 2 diabetes is accompanied by diminishing islet β-cell mass and function. It has been proposed that β-cells are lost not only through apoptosis, but also by dedifferentiating into progenitor-like cells. There is therefore much interest in the mechanisms which define and maintain β-cell identity....

journal_title：Biochemical Society transactions

authors： Pullen TJ,Rutter GA

更新日期：2013-06-01 00:00:00

abstract：:The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks o...

journal_title：Biochemical Society transactions

authors： Lochhead PA,Gilley R,Cook SJ

更新日期：2012-02-01 00:00:00

abstract：:RNase A (1 mM) was incubated with glucose (0.4 M) at 37 degrees C for up to 14 days in phosphate buffer (0.2 M, pH 7.4), digested with trypsin and analysed by LC-MS. The major sites of fructoselysine formation were Lys(1), Lys(7), Lys(37) and Lys(41). Three of these sites (Lys(7), Lys(37) and Lys(41)) were also the ma...

journal_title：Biochemical Society transactions

authors： Cotham WE,Hinton DJ,Metz TO,Brock JW,Thorpe SR,Baynes JW,Ames JM

更新日期：2003-12-01 00:00:00

abstract：:Zebrafish (Danio rerio) are becoming an increasingly powerful model organism to study the role of metabolism in disease. Since its inception, the zebrafish model has relied on unique attributes such as the transparency of embryos, high fecundity and conservation with higher vertebrates, to perform phenotype-driven che...

journal_title：Biochemical Society transactions

authors： Salmi TM,Tan VWT,Cox AG

更新日期：2019-02-28 00:00:00

abstract：:We have been analysing the signalling systems that couple to receptors of the TIR (Toll/interleukin-1 receptor) family, which signal through a common cytoplasm region; the TIR domain. These systems are of both practical and fundamental biological significance, being central to the pathogenesis of chronic inflammatory ...

journal_title：Biochemical Society transactions

authors： Dower SK,Qwarnstrom EE

更新日期：2003-12-01 00:00:00

abstract：:Based on recent theoretical results on optimal flux distributions in kinetic metabolic networks, we explore the congruences and differences between solutions of kinetic optimization problems and results obtained by constraint-based methods. We demonstrate that, for a certain resource allocation problem, kinetic optimi...

journal_title：Biochemical Society transactions

authors： Müller S,Regensburger G,Steuer R

更新日期：2015-12-01 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

journal_title：Biochemical Society transactions

authors： Gnaiger E,Kuznetsov AV

更新日期：2002-04-01 00:00:00

abstract：:Mice devoid of the original uncoupling protein UCP1 have provided opportunities to delineate UCP1 function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis....

journal_title：Biochemical Society transactions

authors： Nedergaard J,Golozoubova V,Matthias A,Shabalina I,Ohba K,Ohlson K,Jacobsson A,Cannon B

更新日期：2001-11-01 00:00:00

abstract：:SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the ...

journal_title：Biochemical Society transactions

authors： Shih HM,Chang CC,Kuo HY,Lin DY

更新日期：2007-12-01 00:00:00

abstract：:CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In...

journal_title：Biochemical Society transactions

authors： Elmore JP,McGee MC,Nidetz NF,Anannya O,Huang W,August A

更新日期：2020-02-28 00:00:00

abstract：:Mitochondrial disorders are a group of genetic diseases affecting the energy-converting process of oxidative phosphorylation. The extreme variability of symptoms, organ involvement, and clinical course represent a challenge to the development of effective therapeutic interventions. However, new possibilities have rece...

journal_title：Biochemical Society transactions

authors： Viscomi C

更新日期：2016-10-15 00:00:00

abstract：:The neurotrophins nerve growth factor, brain-derived neurotrophic factor, NT-3 (neurotrophin 3) and NT-4 are known for regulating neuron development, function and survival. Beyond this, neurotrophins were found to exert multiple effects on non-neuronal cells such as immune cells, smooth muscle and epithelial cells. In...

journal_title：Biochemical Society transactions

authors： Rochlitzer S,Nassenstein C,Braun A

更新日期：2006-08-01 00:00:00

abstract：:Most of the effects of the signalling molecule nitric oxide (NO) are mediated by the stimulation of the NO-sensitive GC (guanylate cyclase) and the subsequent increase in cGMP formation. The enzyme contains a prosthetic haem group, which mediates NO stimulation. In addition to the physiological activator NO, NO-sensit...

journal_title：Biochemical Society transactions

authors： Koesling D,Mullershausen F,Lange A,Friebe A,Mergia E,Wagner C,Russwurm M

更新日期：2005-11-01 00:00:00

abstract：:The discovery that nuclear factor erythroid 2-related factor 2 (Nrf2) undergoes translocational oscillations from cytoplasm to nucleus in human cells with frequency modulation linked to activation of a stress-stimulated cytoprotective response raises the prospect that the Nrf2 works mechanistically analogous to a wire...

journal_title：Biochemical Society transactions

authors： Xue M,Momiji H,Rabbani N,Bretschneider T,Rand DA,Thornalley PJ

更新日期：2015-08-01 00:00:00

abstract：:Biotin, which serves as a carboxyl group carrier in reactions catalyzed by biotin-dependent carboxylases, is essential for life in most organisms. To function in carboxylate transfer, the vitamin must be post-translationally linked to a specific lysine residue on the biotin carboxyl carrier (BCC) of a carboxylase in a...

journal_title：Biochemical Society transactions

authors： Beckett D

更新日期：2018-12-17 00:00:00

abstract：:The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

journal_title：Biochemical Society transactions

authors： Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

更新日期：2000-12-01 00:00:00

abstract：:The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a prefere...

journal_title：Biochemical Society transactions

authors： Del-Corso A,Cappiello M,Moschini R,Balestri F,Mura U,Ipata PL

更新日期：2019-12-20 00:00:00

abstract：:The process of information exchange between two homologous DNA duplexes is known as homologous recombination (HR) or double-strand break repair (DSBR), depending on the context. HR is the fundamental process underlying the genome shuffling that expands genetic diversity (for example during meiosis in eukaryotes). DSBR...

journal_title：Biochemical Society transactions

authors： White MF

更新日期：2011-01-01 00:00:00

abstract：:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

journal_title：Biochemical Society transactions

authors： Cheang QW,Xin L,Chea RYF,Liang ZX

更新日期：2019-02-28 00:00:00

abstract：:The adhesion of cells to the extracellular matrix is a dynamic process, mediated by a series of cell-surface and matrix-associated molecules that interact with each other in a spatially and temporally regulated manner. These interactions play a major role in tissue formation, cellular migration and the induction of ad...

journal_title：Biochemical Society transactions

authors： Zaidel-Bar R,Cohen M,Addadi L,Geiger B

更新日期：2004-06-01 00:00:00

abstract：:c-Type cytochromes are characterized by covalent attachment of haem to protein through thioether bonds between the vinyl groups of the haem and the thiols of a Cys-Xaa-Xaa-Cys-His motif. Proteins of this type play crucial roles in the biochemistry of the nitrogen cycle. Many Gram-negative bacteria use the Ccm (cytochr...

journal_title：Biochemical Society transactions

authors： Allen JW,Ferguson SJ

更新日期：2006-02-01 00:00:00

abstract：:Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

journal_title：Biochemical Society transactions

authors： De Coppi P

更新日期：2014-06-01 00:00:00

abstract：:Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can ...

journal_title：Biochemical Society transactions

authors： Bjedov I,Partridge L

更新日期：2011-04-01 00:00:00

abstract：:Fatty acid biosynthesis is catalysed in most bacteria by a group of highly conserved proteins known as the Type II fatty acid synthase (FAS) system. The Type II system organization is distinct from its mammalian counterpart and offers several unique sites for selective inhibition by antibacterial agents. There has bee...

journal_title：Biochemical Society transactions

authors： Marrakchi H,Zhang YM,Rock CO

更新日期：2002-11-01 00:00:00

abstract：:In this work we present a probabilistic model to estimate summaries of Affymetrix GeneChip probe level data. Comparisons with two different models were made both on a publicly available dataset and on a study performed in our laboratory, showing that our model performs better for consistency of fold change. ...

journal_title：Biochemical Society transactions

authors： Milo M,Fazeli A,Niranjan M,Lawrence ND

更新日期：2003-12-01 00:00:00

abstract：:The UPR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of ER stress has expanded tremendously since, moving from basic biology in yeast to human neurodegenerative, inflammatory, cardiovascular and neoplastic diseases. The ER stress response has als...

journal_title：Biochemical Society transactions

authors： Cnop M,Igoillo-Esteve M,Cunha DA,Ladrière L,Eizirik DL

更新日期：2008-10-01 00:00:00

abstract：:The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules...

journal_title：Biochemical Society transactions

authors： Cooper CD,Newman JA,Gileadi O

更新日期：2014-02-01 00:00:00

abstract：:Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly ...

journal_title：Biochemical Society transactions

authors： Paladin L,Tosatto SC

更新日期：2015-10-01 00:00:00