Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.

abstract：:Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface. After reaching the early endosome, they are ubiquitinated within their cytosolic domain and are consequently sorted away from recycling receptors. They are then incorpora...

journal_title：Biochemical Society transactions

authors： Woodman P

更新日期：2009-02-01 00:00:00

abstract：:The examples shown here illustrate the power of gene targeting to the epidermis as a means of developing animal models for the study of human skin diseases. In this short review, I have focused on contributions which stem predominantly from my own laboratory [31, 32, 34, 37, 47]. However, other laboratories have also ...

journal_title：Biochemical Society transactions

authors： Fuchs E

更新日期：1991-11-01 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear intermediate filaments the A-type lamins, result in a wide variety of diseases known as laminopathies. Some of them, such as familial partial lipodystrophy of Dunnigan and metabolic laminopathies, are characterized by lipodystrophic syndromes with altered fat distributi...

journal_title：Biochemical Society transactions

authors： Bidault G,Vatier C,Capeau J,Vigouroux C,Béréziat V

更新日期：2011-12-01 00:00:00

abstract：:The advantages of Hansenula polymorpha as a new yeast expression system are discussed in terms of the powerful and regulatable methanol oxidase promoter and the organism's ability to grow on cheap carbon sources. The development of techniques for conventional genetic analysis is described. A total of 218 mutants have ...

journal_title：Biochemical Society transactions

authors： Sudbery PE,Gleeson MA,Veale RA,Ledeboer AM,Zoetmulder MC

更新日期：1988-12-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activati...

journal_title：Biochemical Society transactions

authors： Horton JD

更新日期：2002-11-01 00:00:00

abstract：:It is now clear that NSPs (neutrophil serine proteases), including elastase, Pr3 (proteinase 3) and CatG (cathepsin G) are major pathogenic determinants in chronic inflammatory disorders of the lungs. Two unglycosylated natural protease inhibitors, SLPI (secretory leucocyte protease inhibitor) and elafin, and its prec...

journal_title：Biochemical Society transactions

authors： Zani ML,Tanga A,Saidi A,Serrano H,Dallet-Choisy S,Baranger K,Moreau T

更新日期：2011-10-01 00:00:00

abstract：:mRNA instability is an intrinsic property that permits timely changes in gene expression by limiting the lifetime of a transcript. The RNase e of Escherichia coli is a single-strand-specific endo-nuclease involved in the processing of rRNA and the degradation of mRNA. A nucleolytic multi-enzyme complex now known as th...

journal_title：Biochemical Society transactions

authors： Carpousis AJ

更新日期：2002-04-01 00:00:00

abstract：:Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negati...

journal_title：Biochemical Society transactions

authors： Hardiman CA,McDonough JA,Newton HJ,Roy CR

更新日期：2012-12-01 00:00:00

abstract：:SOEs (sulfite-oxidizing enzymes) are physiologically vital and occur in all forms of life. During the catalytic cycle, the five-co-ordinate square pyramidal oxo-molybdenum active site passes through the Mo(V) state, and intimate details of the structure can be obtained from variable frequency pulsed EPR spectroscopy t...

journal_title：Biochemical Society transactions

authors： Enemark JH,Astashkin AV,Raitsimring AM

更新日期：2008-12-01 00:00:00

abstract：:The intestinal epithelium represents one of our most important interfaces with the external environment. It must remain tightly balanced to allow nutrient absorption, but maintain barrier function and immune homoeostasis, a failure of which results in chronic infection or debilitating inflammatory bowel disease (IBD)....

journal_title：Biochemical Society transactions

authors： Worthington JJ

更新日期：2015-08-01 00:00:00

abstract：:Invertebrates use a wide range of peptides as transmitters and hormones to regulate complex behaviour, physiology and development. These animals, especially those that are amenable to genetic study and are the subject of genome-sequencing projects, provide powerful model systems for understanding the functions of pept...

journal_title：Biochemical Society transactions

authors： Isaac RE,Siviter RJ,Stancombe P,Coates D,Shirras AD

更新日期：2000-01-01 00:00:00

abstract：:We have identified three groups of growth-constraint genes using mosaic genetic screens in Drosophila melanogaster, including PTEN (phosphatase and tensin homologue deleted on chromosome 10), and the tuberous sclerosis complex (TSC) genes, Tsc1 and Tsc2. Our studies show that all three groups of genes participate in m...

journal_title：Biochemical Society transactions

authors： Potter CJ,Pedraza LG,Huang H,Xu T

更新日期：2003-06-01 00:00:00

abstract：:Metabolic and epidemiologic studies support the idea that the type of dietary fat is more important than the total amount of fat with respect to the development of atherosclerosis and the risk of cardiovascular heart disease. Dietary fat is carried in CMs (chylomicrons), which can be taken up by macrophages without ne...

journal_title：Biochemical Society transactions

authors： Cabello-Moruno R,Perona JS,Ruiz-Gutierrez V

更新日期：2007-06-01 00:00:00

abstract：:PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of som...

journal_title：Biochemical Society transactions

authors： Kafasla P,Mickleburgh I,Llorian M,Coelho M,Gooding C,Cherny D,Joshi A,Kotik-Kogan O,Curry S,Eperon IC,Jackson RJ,Smith CW

更新日期：2012-08-01 00:00:00

abstract：:The serum- and glucocorticoid-inducible kinase SGK1 is an ubiquitously expressed kinase with the ability to regulate a variety of transport systems. Recent observations point to a role of SGK1 in the regulation of diverse physiological functions such as epithelial transport and cardiac and neuronal excitability. At le...

journal_title：Biochemical Society transactions

authors： Lang F,Vallon V,Grahammer F,Palmada M,Böhmer C

更新日期：2005-02-01 00:00:00

abstract：:Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...

journal_title：Biochemical Society transactions

authors： Chivet M,Javalet C,Hemming F,Pernet-Gallay K,Laulagnier K,Fraboulet S,Sadoul R

更新日期：2013-02-01 00:00:00

abstract：:There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3. Receptor activation of Class I PI3Ks stimulates the phosphorylation of PI(4,5)P2 to form PI(3,4,5)P3. PI(3,4,5)P3 is an important messenger molecule that is part...

journal_title：Biochemical Society transactions

authors： Hawkins PT,Stephens LR

更新日期：2016-02-01 00:00:00

abstract：:Sugars that are readily respired by plant cells inhibit greening when dO2 and mu are relatively high. As sugar concentration in the batch culture medium is depleted and mu declines, greening is permitted. The mechanism of this effect has not been satisfactorily explained. ...

journal_title：Biochemical Society transactions

authors： Dalton C

更新日期：1980-08-01 00:00:00

abstract：:Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction s...

journal_title：Biochemical Society transactions

authors： Campbell ID

更新日期：2008-04-01 00:00:00

abstract：:PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of ...

journal_title：Biochemical Society transactions

authors： Bingle CD,Bingle L,Craven CJ

更新日期：2011-08-01 00:00:00

abstract：:A-type laminopathies are a group of diseases resulting from mutations in the intermediate filament proteins lamin A and C (both encoded by the LMNA gene), but for which the pathogenic mechanisms are little understood. In some laminopathies, there is a good correlation between the presence of a specific LMNA mutation a...

journal_title：Biochemical Society transactions

authors： Scharner J,Gnocchi VF,Ellis JA,Zammit PS

更新日期：2010-02-01 00:00:00

abstract：:Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the initiator of the coagulation cascade, Factor VIIa, binds to its cofactor, tissue factor, and its substrate, Factor X, via exosite interactions to form a ternary cata...

journal_title：Biochemical Society transactions

authors： Amour A,Hutchinson J,Ruiz Avendaño AM,Ratcliffe S,Alvarez E,Martin J,Toomey JR,Senger S,Wolfendale M,Mooney C

更新日期：2007-06-01 00:00:00

abstract：:Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro...

journal_title：Biochemical Society transactions

authors： Jäschke A,Stuhlmann F,Bebenroth D,Keiper S,Wombacher R

更新日期：2002-11-01 00:00:00

abstract：:Pancreatic cancer is the fourth most common cause of death from cancer in the world and the sixth in Europe. Pancreatic cancer is more frequent in males than females. Worldwide, following diagnosis of pancreatic cancer, <2% of patients survive for 5 years, 8% survive for 2 years and <50% survive for only approx. 3 mon...

journal_title：Biochemical Society transactions

authors： Szajda SD,Waszkiewicz N,Chojnowska S,Zwierz K

更新日期：2011-01-01 00:00:00

abstract：:A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute to progression of the tumour. This review discusses the po...

journal_title：Biochemical Society transactions

authors： Saeland E,van Kooyk Y

更新日期：2011-01-01 00:00:00

abstract：:FtsK is a multifunctional protein, which, in Escherichia coli, co-ordinates the essential functions of cell division, DNA unlinking and chromosome segregation. Its C-terminus is a DNA translocase, the fastest yet characterized, which acts as a septum-localized DNA pump. FtsK's C-terminus also interacts with the XerCD ...

journal_title：Biochemical Society transactions

authors： Grainge I

更新日期：2013-04-01 00:00:00

abstract：:IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha. The second IL-13R (IL-13 receptor) ha...

journal_title：Biochemical Society transactions

authors： Andrews AL,Nordgren IK,Kirby I,Holloway JW,Holgate ST,Davies DE,Tavassoli A

更新日期：2009-08-01 00:00:00

abstract：:Assembly of ribonucleoprotein complexes is a facilitated quality-controlled process that typically includes modification to the RNA component from precursor to mature form. The SRP (signal recognition particle) is a cytosolic ribonucleoprotein that catalyses protein targeting to the endoplasmic reticulum. Assembly of ...

journal_title：Biochemical Society transactions

authors： Leung E,Brown JD

更新日期：2010-08-01 00:00:00

abstract：:Synthetic gene circuits allow us to govern cell behavior in a programmable manner, which is central to almost any application aiming to harness engineered living cells for user-defined tasks. Transcription factors (TFs) constitute the 'classic' tool for synthetic circuit construction but some of their inherent constra...

journal_title：Biochemical Society transactions

authors： Santos-Moreno J,Schaerli Y

更新日期：2020-10-30 00:00:00

abstract：:Human heparan sulphate N-deacetylase/N-sulphotransferase 1 sulphates the NH(3) (+) group of the glucosamine moiety of the heparan chain in heparan sulphate/heparin biosynthesis. An open cleft that runs perpendicular to the sulphate donor 3'-phosphoadenosine 5'-phosphosulphate may constitute the acceptor substrate-bind...

journal_title：Biochemical Society transactions

authors： Kakuta Y,Li L,Pedersen LC,Pedersen LG,Negishi M

更新日期：2003-04-01 00:00:00