Abstract:
:The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a preferential precursor for nucleotides synthesis is discussed. The low reliability of ribose in its furanosidic hemiacetal form must have played ab initio against the choice of d-ribose for the generation of d-ribose-5-phosphate, the fundamental precursor of the ribose moiety of nucleotides. The latter, which is instead generated through the 'pentose phosphate pathway' is strictly linked to the affordable and reliable pyranosidic structure of d-glucose.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Del-Corso A,Cappiello M,Moschini R,Balestri F,Mura U,Ipata PLdoi
10.1042/BST20190749subject
Has Abstractpub_date
2019-12-20 00:00:00pages
1931-1940issue
6eissn
0300-5127issn
1470-8752pii
221031journal_volume
47pub_type
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