Dissimilatory sulfur cycling in oxygen minimum zones: an emerging metagenomics perspective.

abstract：:FcRn was originally identified as the receptor responsible for IgG binding to the intestinal epithelium of neonatal rats and mice. FcRn transports IgG from milk across the intestinal epithelial cells of the suckling animal. Subsequently, FcRn was detected in tissues involved in the transmission of IgG from mother to f...

journal_title：Biochemical Society transactions

authors： Simister NE,Jacobowitz Israel E,Ahouse JC,Story CM

更新日期：1997-05-01 00:00:00

abstract：:Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

journal_title：Biochemical Society transactions

authors： Falasca M,Maffucci T

更新日期：2007-04-01 00:00:00

abstract：:The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

journal_title：Biochemical Society transactions

authors： Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

更新日期：2000-12-01 00:00:00

abstract：:Numerous bacterial proteins involved in the nitrogen cycle, and other processes, require c-type haem as a cofactor. c-type cytochromes are formed by covalent attachment of haem to the conserved CXXCH motif. Here, we briefly review what is presently known about cytochrome c maturation in Bacillus subtilis with particul...

journal_title：Biochemical Society transactions

authors： Crow A,Le Brun NE,Oubrie A

更新日期：2005-02-01 00:00:00

abstract：:The FG (female gametophyte) of flowering plants (angiosperms) is a simple highly polar structure composed of only a few cell types. The FG develops from a single cell through mitotic divisions to generate, depending on the species, four to 16 nuclei in a syncytium. These nuclei are then partitioned into three or four ...

journal_title：Biochemical Society transactions

authors： Lituiev DS,Grossniklaus U

更新日期：2014-04-01 00:00:00

abstract：:Mutations in MYO7A (myosin VIIa) cause Usher syndrome type 1B, a disorder involving profound congenital deafness and progressive blindness. In the retina, most MYO7A is localized in the apical region of the RPE (retinal pigmented epithelial) cells, and a small amount is associated with the ciliary and periciliary memb...

journal_title：Biochemical Society transactions

authors： Williams DS,Lopes VS

更新日期：2011-10-01 00:00:00

abstract：:Vitamin B12 (cobalamin) is a cobalt-containing modified tetrapyrrole that is an essential nutrient for higher animals. Its biosynthesis is restricted to certain bacteria and requires approximately 30 enzymatic steps for its complete de novo construction. Remarkably, two distinct biosynthetic pathways exist, which are ...

journal_title：Biochemical Society transactions

authors： Moore SJ,Warren MJ

更新日期：2012-06-01 00:00:00

abstract：:Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MB...

journal_title：Biochemical Society transactions

authors： Valdimarsson H

更新日期：2003-08-01 00:00:00

abstract：:The adhesion of cells to the extracellular matrix is a dynamic process, mediated by a series of cell-surface and matrix-associated molecules that interact with each other in a spatially and temporally regulated manner. These interactions play a major role in tissue formation, cellular migration and the induction of ad...

journal_title：Biochemical Society transactions

authors： Zaidel-Bar R,Cohen M,Addadi L,Geiger B

更新日期：2004-06-01 00:00:00

abstract：:The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated protein...

journal_title：Biochemical Society transactions

authors： Lemonidis K,Werno MW,Greaves J,Diez-Ardanuy C,Sanchez-Perez MC,Salaun C,Thomson DM,Chamberlain LH

更新日期：2015-04-01 00:00:00

abstract：:To maintain genomic stability, despite constant exposure to agents that damage DNA, eukaryotic cells have developed elaborate and highly conserved pathways of DNA damage sensing, signalling and repair. In this review, we concentrate mainly on what we know about DNA damage sensing with particular reference to Lcd1p, a ...

journal_title：Biochemical Society transactions

authors： Bradbury JM,Jackson SP

更新日期：2003-02-01 00:00:00

abstract：:Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange, are scaffolded by specific complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-relate...

journal_title：Biochemical Society transactions

authors： Wilhelm LP,Tomasetto C,Alpy F

更新日期：2016-04-15 00:00:00

abstract：:Pancreatic cancer is the fourth most common cause of death from cancer in the world and the sixth in Europe. Pancreatic cancer is more frequent in males than females. Worldwide, following diagnosis of pancreatic cancer, <2% of patients survive for 5 years, 8% survive for 2 years and <50% survive for only approx. 3 mon...

journal_title：Biochemical Society transactions

authors： Szajda SD,Waszkiewicz N,Chojnowska S,Zwierz K

更新日期：2011-01-01 00:00:00

abstract：:Muscles are responsible for generating the forces required for the movement of multicellular organisms. Microscopically, these forces arise as a consequence of motor proteins (myosin) pulling and sliding along actin filaments. Current knowledge states that the molecular forces between actin and myosin are linear in na...

journal_title：Biochemical Society transactions

authors： Nielsen BG

更新日期：2004-11-01 00:00:00

abstract：:Cyclic nucleotide PDEs (phosphodiesterases) regulate cellular levels of cAMP and cGMP by controlling the rate of degradation. Several mammalian PDE isoforms possess N-terminal GAF (found in cGMP PDEs, Anabaena adenylate cyclases and Escherichia coli FhlA; where FhlA is formate hydrogen lyase transcriptional activator)...

journal_title：Biochemical Society transactions

authors： Cann MJ

更新日期：2007-11-01 00:00:00

abstract：:The interaction of chemokines and GAGs (glycosaminoglycans) on endothelial surfaces is a crucial step for establishing a chemotactic gradient which leads to the functional presentation of chemokines to their GPCRs (G-protein-coupled receptors) and thus to activation of approaching leucocytes. Based on molecular modell...

journal_title：Biochemical Society transactions

authors： Potzinger H,Geretti E,Brandner B,Wabitsch V,Piccinini AM,Rek A,Kungl AJ

更新日期：2006-06-01 00:00:00

abstract：:Protein biochips are emerging in two distinct formats. The first involves high-density immobilized arrays of recognition molecules (e.g. antibodies), where target binding is monitored indirectly (e.g. via fluorescence). This technology is in its infancy, being limited by the availability of suitable binding molecules ...

journal_title：Biochemical Society transactions

authors： Chapman K

更新日期：2002-04-01 00:00:00

abstract：:Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the abili...

journal_title：Biochemical Society transactions

authors： Jorfi S,Inal JM

更新日期：2013-02-01 00:00:00

abstract：:Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can ...

journal_title：Biochemical Society transactions

authors： Bjedov I,Partridge L

更新日期：2011-04-01 00:00:00

abstract：:Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...

journal_title：Biochemical Society transactions

authors： Chivet M,Javalet C,Hemming F,Pernet-Gallay K,Laulagnier K,Fraboulet S,Sadoul R

更新日期：2013-02-01 00:00:00

abstract：:The intestinal epithelium represents one of our most important interfaces with the external environment. It must remain tightly balanced to allow nutrient absorption, but maintain barrier function and immune homoeostasis, a failure of which results in chronic infection or debilitating inflammatory bowel disease (IBD)....

journal_title：Biochemical Society transactions

authors： Worthington JJ

更新日期：2015-08-01 00:00:00

abstract：:Post-translational modification (PTM) of histones has been investigated in eukaryotes for years, revealing its widespread occurrence and functional importance. Many PTMs affect chromatin folding and gene activity. Only recently the occurrence of such modifications has been recognized in bacteria. However, it is unclea...

journal_title：Biochemical Society transactions

authors： Dilweg IW,Dame RT

更新日期：2018-10-19 00:00:00

abstract：:Crystal structure data for Escherichia coli beta-ketoacyl synthase (KAS) I with C(10) and C(12) fatty acid substrates bound in conjunction with results from mutagenizing residues in the active site leads to a model for catalysis. Differences from and similarities to the other Claisen enzymes carrying out decarboxylati...

journal_title：Biochemical Society transactions

authors： von Wettstein-Knowles P,Olsen J,Arnvig Mcguire K,Larsen S

更新日期：2000-12-01 00:00:00

abstract：:The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we rev...

journal_title：Biochemical Society transactions

authors： La Teana A,Benelli D,Londei P,Bläsi U

更新日期：2013-02-01 00:00:00

abstract：:Multiple cellular proteins have been identified as participating in Toll/interleukin-1 receptor-mediated inflammatory gene expression. The continuing isolation of novel components, based on sequence similarities, protein-protein interactions and protein purification, suggests that many elements of this signalling netw...

journal_title：Biochemical Society transactions

authors： Kiss-Toth E,Wyllie DH,Holland K,Marsden L,Jozsa V,Oxley KM,Polgar T,Qwarnstrom EE,Dower SK

更新日期：2005-12-01 00:00:00

abstract：:Delineating the molecular pathways underlying seizure-induced neuronal death may yield novel strategies for brain protection against prolonged or repetitive seizures. Glutamate-mediated excitotoxicity and necrosis is a primary contributing mechanism but seizures also activate programmed (apoptotic) cell death pathways...

journal_title：Biochemical Society transactions

authors： Henshall DC

更新日期：2007-04-01 00:00:00

abstract：:There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

journal_title：Biochemical Society transactions

authors： Wisniewski T,Brown DR,Sigurdsson EM

更新日期：2002-08-01 00:00:00

abstract：:Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

journal_title：Biochemical Society transactions

authors： Matsumoto S,Masai H

更新日期：2013-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is the causative agent of chicken pox (varicella) and shingles (zoster). Although considered benign diseases, both varicella and zoster can cause complications. Zoster is painful and can lead to post herpetic neuralgia. VZV has also been linked to stroke, related to giant cell arteritis in...

journal_title：Biochemical Society transactions

authors： Oliver SL,Zhou M,Arvin AM

更新日期：2020-12-01 00:00:00

abstract：:Nitrogenase activity in Rhodospirillum rubrum is post-translationally regulated by DRAG (dinitrogenase reductase glycohydrolase) and DRAT (dinitrogenase reductase ADP-ribosylation transferase). When a sudden increase in fixed nitrogen concentration or energy depletion is sensed by the cells, DRAG is inactivated and DR...

journal_title：Biochemical Society transactions

authors： Wang H,Norén A

更新日期：2006-02-01 00:00:00