Abstract:
:The biophysical characteristics of vascular tissues are dependent largely on the properties of fibrillar collagens. Considering the predominant structural component, collagen type I, the present review describes the mechanisms of formation and maturation of lysyl oxidase-mediated cross-linking, leading to an understanding of how intracellular collagen-modifying enzymes affect the patterns of cross-links produced. An important distinction is made between the enzyme-mediated cross-linking, essential for optimum tissue function, and the non-enzymatic aging processes that generally lead to structural changes deleterious to function. Finally, the extracellular matrix of vascular tissue is a multicomponent system and the role of other major constituents, such as elastin and glycosaminoglycans, in modifying tissue properties should be considered. Some details of newer methods being developed to quantify these constituents will be presented.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Robins SPdoi
10.1042/BST0350849subject
Has Abstractpub_date
2007-11-01 00:00:00pages
849-52issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST0350849journal_volume
35pub_type
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