Abstract:
:DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article, we provide an overview of theoretical and experimental approaches to understand the interplay between various manifestations of topological constraints acting on replicating DNA molecules. Data discussed reveal that DNA entanglements (supercoils and catenanes) play an active role in preventing the formation of deleterious knots.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Schvartzman JB,Martínez-Robles ML,Hernández P,Krimer DBdoi
10.1042/BST20120281subject
Has Abstractpub_date
2013-04-01 00:00:00pages
646-51issue
2eissn
0300-5127issn
1470-8752pii
BST20120281journal_volume
41pub_type
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