Abstract:
:The Golgi complex (GC) has an essential role in the processing and sorting of proteins and lipids. The GC of mammalian cells is composed of stacks of cisternae connected by membranous tubules to create a continuous network, the Golgi ribbon, whose maintenance requires several core and accessory proteins. Despite this complex structural organization, the Golgi apparatus is highly dynamic, and this property becomes particularly evident during mitosis, when the ribbon undergoes a multistep disassembly process that allows its correct partitioning and inheritance by the daughter cells. Importantly, alterations of the Golgi structure are associated with a variety of physiological and pathological conditions. Here, we review the core mechanisms and signaling pathways involved in both the maintenance and disassembly of the Golgi ribbon, and we also report on the signaling pathways that connect the disassembly of the Golgi ribbon to mitotic entry and progression.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Ayala I,Mascanzoni F,Colanzi Adoi
10.1042/BST20190646subject
Has Abstractpub_date
2020-02-28 00:00:00pages
245-256issue
1eissn
0300-5127issn
1470-8752pii
222016journal_volume
48pub_type
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