Molecular mechanisms for regulation of AMPAR trafficking by PICK1.

abstract：:The study of regulated exocytosis uniquely allows the direct measurement of intracellular membrane fusion events in real time. We have exploited this to examine factors that regulate not only the extent but also the dynamics of single fusion/release events. The general strategy used has been to assess exocytosis in tr...

journal_title：Biochemical Society transactions

authors： Burgoyne RD,Fisher RJ,Graham ME,Haynes LP,Morgan A

更新日期：2001-08-01 00:00:00

abstract：:Glucose-stimulated insulin secretion from pancreatic beta-cells requires the kinesin-1/Kif5B-mediated transport of insulin granules along microtubules. 5'-AMPK (5'-AMP-activated protein kinase) is a heterotrimeric serine/threonine kinase which is activated in beta-cells at low glucose concentrations, but inhibited as ...

journal_title：Biochemical Society transactions

authors： McDonald A,Fogarty S,Leclerc I,Hill EV,Hardie DG,Rutter GA

更新日期：2010-02-01 00:00:00

abstract：:PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within surviving neurons. Although heritability st...

journal_title：Biochemical Society transactions

authors： Ross OA,Farrer MJ

更新日期：2005-08-01 00:00:00

abstract：:Resveratrol (3,4',5-trihydroxystilbene) is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. During the last years, it has been the focus of numerous in vitro and in vivo studies investigating its biological attributes, which include mainly antioxidant a...

journal_title：Biochemical Society transactions

authors： de la Lastra CA,Villegas I

更新日期：2007-11-01 00:00:00

abstract：:Cyclin A must be degraded at prometaphase in order to allow mitosis progression. Nevertheless, the signals that trigger cyclin A degradation at mitosis have been largely elusive. In the present paper, we review the status of cyclin A degradation in the light of recent evidence indicating that acetylation plays a role ...

journal_title：Biochemical Society transactions

authors： Mateo F,Vidal-Laliena M,Pujol MJ,Bachs O

更新日期：2010-02-01 00:00:00

abstract：:Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S rRNA. Growth factors trigger a rapid increase in pol III activity and this is essential for cell proliferation. The transcription factor TFIIIB pl...

journal_title：Biochemical Society transactions

authors： Mauger E,Scott PH

更新日期：2004-12-01 00:00:00

abstract：:Insect and mammalian circadian clocks show striking similarities. They utilize homologous clock genes, generating self-sustained circadian oscillations in distinct master clocks of the brain, which then control rhythmic behaviour. The molecular mechanisms of rhythm generation were first uncovered in the fruit fly Dros...

journal_title：Biochemical Society transactions

authors： Helfrich-Förster C

更新日期：2005-11-01 00:00:00

abstract：:Studies on those enzymes and electron-transfer proteins involved in the catabolism of 'C1' substrates in methylotrophic bacteria have provided a wealth of information concerning the transfer of electrons and hydrogen by quantum tunnelling mechanisms. With regard to H-transfer, studies with MADH have provided the first...

journal_title：Biochemical Society transactions

authors： Scrutton NS

更新日期：1999-12-01 00:00:00

abstract：:RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors). Specifically for the CT (calcitonin) receptor-like receptor and the CT receptor, this results in profound changes in ligand binding and receptor pharmacology, al...

journal_title：Biochemical Society transactions

authors： Conner AC,Simms J,Hay DL,Mahmoud K,Howitt SG,Wheatley M,Poyner DR

更新日期：2004-11-01 00:00:00

abstract：:The development of natural tissues, organs and bodies depends on mechanisms of patterning and of morphogenesis, typically (but not invariably) in that order, and often several times at different final scales. Using synthetic biology to engineer patterning and morphogenesis will both enhance our basic understanding of ...

journal_title：Biochemical Society transactions

authors： Davies JA,Glykofrydis F

更新日期：2020-06-30 00:00:00

abstract：:The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute r...

journal_title：Biochemical Society transactions

authors： Sawers RG

更新日期：2005-02-01 00:00:00

abstract：:The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby pr...

journal_title：Biochemical Society transactions

authors： Dasso M

更新日期：2006-11-01 00:00:00

abstract：:Protein biochips are emerging in two distinct formats. The first involves high-density immobilized arrays of recognition molecules (e.g. antibodies), where target binding is monitored indirectly (e.g. via fluorescence). This technology is in its infancy, being limited by the availability of suitable binding molecules ...

journal_title：Biochemical Society transactions

authors： Chapman K

更新日期：2002-04-01 00:00:00

abstract：:Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine des...

journal_title：Biochemical Society transactions

authors： Fairbairn IP

更新日期：2004-06-01 00:00:00

abstract：:One of the primary functions of AMP-activated protein kinase (AMPK) is to regulate the metabolic pathways in response to reduced cellular energy charge. Most of the known targets of the kinase are cytoplasmic enzymes involved in both catabolic and anabolic metabolism. In addition, activation of AMPK in many cells resu...

journal_title：Biochemical Society transactions

authors： Leff T

更新日期：2003-02-01 00:00:00

abstract：:Squalene epoxidase (Erg1p) is an essential enzyme in the ergosterol biosynthesis pathway in yeast. For its enzymatic activity, Erg1p requires molecular oxygen, NAD(P)H and FAD. Amino acid analysis and sequence alignment with other squalene epoxidases revealed two highly conserved FAD-binding domains, FAD I and FAD II....

journal_title：Biochemical Society transactions

authors： Ruckenstuhl C,Eidenberger A,Lang S,Turnowsky F

更新日期：2005-11-01 00:00:00

abstract：:Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has...

journal_title：Biochemical Society transactions

authors： Coppo L,Ghezzi P

更新日期：2011-10-01 00:00:00

abstract：:Among the several signalling pathways regulated by ubiquitin and ubiquitin-like proteins, the one activating NF-kappaB (nuclear factor kappaB) is certainly one of the best characterized. The regulation of the activity of this transcription factor by members of the ubiquitin family occurs at various levels, imposing ov...

journal_title：Biochemical Society transactions

authors： Lang V,Rodríguez MS

更新日期：2008-10-01 00:00:00

abstract：:The deposition of protein aggregates in various parts of our body gives rise to several devastating diseases, and the development of probes for the selective detection of aggregated proteins is crucial to advance our understanding of the pathogenesis underlying these diseases. LCPs (luminescent conjugated polythiophen...

journal_title：Biochemical Society transactions

authors： Klingstedt T,Nilsson KP

更新日期：2012-08-01 00:00:00

abstract：:Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A ( Staphylococcus aureus ) and Protein G ( Strep...

journal_title：Biochemical Society transactions

authors： Housden NG,Harrison S,Roberts SE,Beckingham JA,Graille M,Stura E,Gore MG

更新日期：2003-06-01 00:00:00

abstract：:Many microalgae are known to accumulate triacylglycerols (TAGs), especially under nitrate starvation. Generally, these TAGs are predominantly constructed of saturated and monounsaturated fatty acids. In contrast, the TAGs of the red microalga Porphyridium cruentum are rich in arachidonic acid (AA, 20:4 omega6) and eic...

journal_title：Biochemical Society transactions

authors： Cohen Z,Khozin-Goldberg I,Adlerstein D,Bigogno C

更新日期：2000-12-01 00:00:00

abstract：:Metabolic and epidemiologic studies support the idea that the type of dietary fat is more important than the total amount of fat with respect to the development of atherosclerosis and the risk of cardiovascular heart disease. Dietary fat is carried in CMs (chylomicrons), which can be taken up by macrophages without ne...

journal_title：Biochemical Society transactions

authors： Cabello-Moruno R,Perona JS,Ruiz-Gutierrez V

更新日期：2007-06-01 00:00:00

abstract：:Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors ...

journal_title：Biochemical Society transactions

authors： Brust-Mascher I,Scholey JM

更新日期：2011-10-01 00:00:00

abstract：:The physiological roles of insulin and insulin-like growth factors (IGFs) are distinct, with insulin acting to regulate cellular uptake and metabolism of fuels, whereas IGFs promote cell growth, survival and differentiation. The only components of signalling pathways known to be unique to insulin and IGFs are their re...

journal_title：Biochemical Society transactions

authors： Siddle K,Ursø B,Niesler CA,Cope DL,Molina L,Surinya KH,Soos MA

更新日期：2001-08-01 00:00:00

abstract：:The spliceosome is a macromolecular machine that carries out the excision of introns from eukaryotic pre-mRNAs and splicing together of exons. Four large RNA-protein complexes, called the U1, U2, U4/U6 and U5 small nuclear ribonucleoprotein particles (snRNPs), and some non-snRNP proteins assemble around three short co...

journal_title：Biochemical Society transactions

authors： Nagai K,Muto Y,Pomeranz Krummel DA,Kambach C,Ignjatovic T,Walke S,Kuglstatter A

更新日期：2001-05-01 00:00:00

abstract：:The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinit...

journal_title：Biochemical Society transactions

authors： Mayans O,Benian GM,Simkovic F,Rigden DJ

更新日期：2013-08-01 00:00:00

abstract：:Bacterial cellular metabolism is renowned for its metabolic diversity and adaptability. However, certain environments present particular challenges. Aerobic metabolism of highly reduced carbon substrates by soil bacteria such as Paracoccus pantotrophus presents one such challenge since it may result in excessive elect...

journal_title：Biochemical Society transactions

authors： Gates AJ,Butler CS,Richardson DJ,Butt JN

更新日期：2011-01-01 00:00:00

abstract：:Biophysical techniques developed during the last three decades have provided an increasingly detailed description of the internal processes associated with ligand capture and release by haem proteins. Myoglobin has long been the paradigm for these studies. More recently, cytochrome P450cam (the camphor-metabolizing cy...

journal_title：Biochemical Society transactions

authors： Lavalette D,Tétreau C,Mouawad L

更新日期：2006-11-01 00:00:00

abstract：:Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there ...

journal_title：Biochemical Society transactions

authors： Agius L,Centelles J,Cascante M

更新日期：2002-04-01 00:00:00

abstract：:One of the major goals of modern plant biotechnology is to manipulate lipid metabolism in oilseed crops to produce new and improved edible and industrial vegetable oils. Lipids constitute the structural components of cellular membranes and act as sources of energy for the germinating seed and are therefore essential t...

journal_title：Biochemical Society transactions

authors： Schnurr JA,Shockey J,Browse J

更新日期：2000-12-01 00:00:00