Ligand migration and escape pathways in haem proteins.

abstract：:Genetic experiments have established an important role for the ubiquitin-like molecule NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) in the regulation of cell growth, viability and development. It is therefore essential to identify the molecular targets for the pathway. Until recently, the c...

journal_title：Biochemical Society transactions

authors： Xirodimas DP

更新日期：2008-10-01 00:00:00

abstract：:In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

journal_title：Biochemical Society transactions

authors： Gnaiger E,Kuznetsov AV

更新日期：2002-04-01 00:00:00

abstract：:Crystal structures combined with biochemical data show that the delta-endotoxins from Bacillus thuringiensis are structurally poised towards large-scale, irreversible conformational changes that transform them from the soluble protein bound at the cell surface into a membrane-embedded form causing lysis of susceptible...

journal_title：Biochemical Society transactions

authors： Li J,Derbyshire DJ,Promdonkoy B,Ellar DJ

更新日期：2001-08-01 00:00:00

abstract：:Prelamin A is the precursor protein of lamin A, a major constituent of the nuclear lamina in higher eukaryotes. Increasing attention to prelamin A processing and function has been given after the discovery, from 2002 to 2004, of diseases caused by prelamin A accumulation. These diseases, belonging to the group of lami...

journal_title：Biochemical Society transactions

authors： Lattanzi G

更新日期：2011-12-01 00:00:00

abstract：:Glyoxalase- and methylglyoxal-related research has required the development of quantitative and reliable techniques for the measurement of methylglyoxal-derived glycation adducts of protein and DNA. There are also other glycation adducts, oxidation adducts and nitration adducts of proteins and oxidation adducts of DNA...

journal_title：Biochemical Society transactions

authors： Rabbani N,Shaheen F,Anwar A,Masania J,Thornalley PJ

更新日期：2014-04-01 00:00:00

abstract：:Reciprocal biochemical and biophysical interactions between tumor cells, stromal cells and the extracellular matrix (ECM) result in a unique tumor microenvironment that determines disease outcome. The cellular component of the tumor microenvironment contributes to tumor growth by providing nutrients, assisting in the ...

journal_title：Biochemical Society transactions

authors： Johan MZ,Samuel MS

更新日期：2019-02-28 00:00:00

abstract：:Formin family proteins (formins) represent an evolutionary conserved protein family encoded in the genome of a wide range of eukaryotes. Formins are hallmarked by a formin homology 1 (FH1) domain juxtaposed to an FH2 domain whereby they control actin and microtubule dynamics. Not surprisingly, formins are best known a...

journal_title：Biochemical Society transactions

authors： Isogai T,Innocenti M

更新日期：2016-12-15 00:00:00

abstract：:Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic gain of function (cytotoxicity associated with protein aggregates). Although potentially harmful, protein sequences predisposed to aggregati...

journal_title：Biochemical Society transactions

authors： Sanchez de Groot N,Torrent M,Villar-Piqué A,Lang B,Ventura S,Gsponer J,Babu MM

更新日期：2012-10-01 00:00:00

abstract：:Biochemical, biophysical and biological studies of oligonucleotides containing lesions at defined sites provide a molecular basis for the effects of DNA lesions. dG (deoxyguanosine) is the most easily oxidized of the four native nucleotides. The chemical reactivity of dG correlates with compilations of mutations, whic...

journal_title：Biochemical Society transactions

authors： Greenberg MM

更新日期：2004-02-01 00:00:00

abstract：:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

journal_title：Biochemical Society transactions

authors： Cheang QW,Xin L,Chea RYF,Liang ZX

更新日期：2019-02-28 00:00:00

abstract：:ATP-binding cassette (ABC) transporters play crucial roles in cellular processes, such as nutrient uptake, drug resistance, cell-volume regulation and others. Despite their importance, all proposed molecular models for transport are based on indirect evidence, i.e. functional interpretation of static crystal structure...

journal_title：Biochemical Society transactions

authors： Husada F,Gouridis G,Vietrov R,Schuurman-Wolters GK,Ploetz E,de Boer M,Poolman B,Cordes T

更新日期：2015-10-01 00:00:00

abstract：:IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha. The second IL-13R (IL-13 receptor) ha...

journal_title：Biochemical Society transactions

authors： Andrews AL,Nordgren IK,Kirby I,Holloway JW,Holgate ST,Davies DE,Tavassoli A

更新日期：2009-08-01 00:00:00

abstract：:The secretin receptor is prototypic of Class II GPCRs (G-protein-coupled receptors), based on its structural and functional characteristics and those of its natural agonist ligand. Secretin represents a linear 27-residue peptide with diffuse pharmacophoric domain. The secretin receptor includes the typical signature s...

journal_title：Biochemical Society transactions

authors： Miller LJ,Dong M,Harikumar KG,Gao F

更新日期：2007-08-01 00:00:00

abstract：:CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins or ONs (oligonucleotides). CPPs and their conjugates were initially thought to translocate through the cell membrane by a non-endocytotic mechanism which has recently been re-evaluated. Basic-a...

journal_title：Biochemical Society transactions

authors： Abes S,Moulton H,Turner J,Clair P,Richard JP,Iversen P,Gait MJ,Lebleu B

更新日期：2007-02-01 00:00:00

abstract：:Yeast cells rely on the SPS-sensing pathway to respond to extracellular amino acids. This nutrient-induced signal transduction pathway regulates gene expression by controlling the activity of two redundant transcription factors: Stp1 and Stp2. These factors are synthesized as latent cytoplasmic proteins with N-termina...

journal_title：Biochemical Society transactions

authors： Ljungdahl PO

更新日期：2009-02-01 00:00:00

abstract：:The free energy landscape can provide a quantitative description of folding dynamics, if determined as a function of an optimally chosen reaction coordinate. The profile together with the optimal coordinate allows one to directly determine such basic properties of folding dynamics as the configurations of the minima a...

journal_title：Biochemical Society transactions

authors： Banushkina PV,Krivov SV

更新日期：2015-04-01 00:00:00

abstract：:Protein-protein interactions are a regulatory mechanism for a number of physiological and pathological cellular processes. Neurodegenerative diseases, such as AD (Alzheimer's disease), are associated with the accelerated production or delayed clearance of protein aggregates. Hence, inhibition of pathologic protein-pro...

journal_title：Biochemical Society transactions

authors： Bose M,Gestwicki JE,Devasthali V,Crabtree GR,Graef IA

更新日期：2005-08-01 00:00:00

abstract：:Squalene epoxidase (Erg1p) is an essential enzyme in the ergosterol biosynthesis pathway in yeast. For its enzymatic activity, Erg1p requires molecular oxygen, NAD(P)H and FAD. Amino acid analysis and sequence alignment with other squalene epoxidases revealed two highly conserved FAD-binding domains, FAD I and FAD II....

journal_title：Biochemical Society transactions

authors： Ruckenstuhl C,Eidenberger A,Lang S,Turnowsky F

更新日期：2005-11-01 00:00:00

abstract：:USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53-mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein-Barr nuclear antigen 1 protein of Epstein-Barr virus binds with high affinity to USP7 and disrupts the USP7-p53 interaction. The...

journal_title：Biochemical Society transactions

authors： Holowaty MN,Frappier L

更新日期：2004-11-01 00:00:00

abstract：:PET (pre-eclamptic toxaemia), characterized by pregnancy-related hypertension and proteinuria, due to widespread endothelial dysfunction, is a primary cause of maternal morbidity. Altered circulating factors, particularly the VEGF (vascular endothelial growth factor) family of proteins and their receptors, are thought...

journal_title：Biochemical Society transactions

authors： Bates DO

更新日期：2011-12-01 00:00:00

abstract：:The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in epigenetic gene silencing. Variations in the SMCHD1 gene are associated with two debilitating human disorders, facioscapulohumeral muscular dystrophy (FSHD) and Bosma arhinia microphthalmia s...

journal_title：Biochemical Society transactions

authors： Gurzau AD,Blewitt ME,Czabotar PE,Murphy JM,Birkinshaw RW

更新日期：2020-08-28 00:00:00

abstract：:The ability to permit gene expression is managed by a set of relatively well known regulatory mechanisms. Nonetheless, this property can also be acquired during a life span as a consequence of environmental stimuli. Interestingly, some acquired information can be passed to the next generation of individuals without mo...

journal_title：Biochemical Society transactions

authors： Mazaira GI,Daneri-Becerra C,Zgajnar NR,Lotufo CM,Galigniana MD

更新日期：2018-02-19 00:00:00

abstract：:Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cy...

journal_title：Biochemical Society transactions

authors： Hamid FM,Makeyev EV

更新日期：2014-08-01 00:00:00

abstract：:Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus entraps microbes and particles removing them from the lungs via the co-ordinated beating of motile cilia. This mechanism of lung defen...

journal_title：Biochemical Society transactions

authors： Ridley C,Thornton DJ

更新日期：2018-10-19 00:00:00

abstract：:Many plant viral RNAs lack the 5'-cap structure that is required on all host mRNAs for interacting with essential translation initiation factors. Instead, uncapped viral RNAs take over the host translation machinery by harbouring sequences that functionally replace the 5'-cap. Recent reports reveal at least eight diff...

journal_title：Biochemical Society transactions

authors： Miller WA,Wang Z,Treder K

更新日期：2007-12-01 00:00:00

abstract：:The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases...

journal_title：Biochemical Society transactions

authors： Krapp A,Simanis V

更新日期：2008-06-01 00:00:00

abstract：:Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures need evaluation in the context of early compared with late metastatic risk prediction. In pre-clinical studies, we and others have shown that various protein-p...

journal_title：Biochemical Society transactions

authors： Weitsman G,Lawler K,Kelleher MT,Barrett JE,Barber PR,Shamil E,Festy F,Patel G,Fruhwirth GO,Huang L,Tullis ID,Woodman N,Ofo E,Ameer-Beg SM,Irshad S,Condeelis J,Gillett CE,Ellis PA,Vojnovic B,Coolen AC,Ng T

更新日期：2014-12-01 00:00:00

abstract：:The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Ther...

journal_title：Biochemical Society transactions

authors： Johnson WE,Roberts S

更新日期：2007-08-01 00:00:00

abstract：:Genetic experiments have indicated that succinoglycan (EPS I), the acidic Calcofluor-binding exopolysaccharide, of the nitrogen-fixing bacterium Rhizobium meliloti strain Rm1021 is required for nodule invasion and possibly for later events in nodule development on alfalfa and other hosts. Fourteen exo loci on the seco...

journal_title：Biochemical Society transactions

authors： Reuber TL,Reed J,Glazebrook J,Glucksmann MA,Ahmann D,Marra A,Walker GC

更新日期：1991-08-01 00:00:00

abstract：:The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice variant (GLAST-1a) in which exon 3 is excluded. Since GLAST-1 expression is regulated in bone in response to osteogenic mechanical stimuli in vivo and binding of glutamate to receptors on osteoblasts increases osteobla...

journal_title：Biochemical Society transactions

authors： Huggett JF,Mustafa A,O'neal L,Mason DJ

更新日期：2002-11-01 00:00:00